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FBXO36 F-box protein 36 [ Homo sapiens (human) ]

Gene ID: 130888, updated on 1-Jun-2020

Summary

Official Symbol
FBXO36provided by HGNC
Official Full Name
F-box protein 36provided by HGNC
Primary source
HGNC:HGNC:27020
See related
Ensembl:ENSG00000153832 MIM:609105
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Fbx36
Summary
Members of the F-box protein family, such as FBXO36, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
Expression
Broad expression in thyroid (RPKM 4.9), testis (RPKM 3.7) and 24 other tissues See more
Orthologs

Genomic context

See FBXO36 in Genome Data Viewer
Location:
2q36.3
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (229922503..230013913)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (230787023..230877825)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene delta/notch like EGF repeat containing Neighboring gene uncharacterized LOC105373923 Neighboring gene thyroid hormone receptor interactor 12 Neighboring gene RNA, U6 small nuclear 613, pseudogene Neighboring gene uncharacterized LOC105373924 Neighboring gene RNA, U6 small nuclear 964, pseudogene Neighboring gene RNA, U6 small nuclear 1027, pseudogene Neighboring gene uncharacterized LOC107985996 Neighboring gene solute carrier family 16 member 14 Neighboring gene RNY4 pseudogene 19

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ37592, FLJ41090

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174899.5NP_777559.3  F-box only protein 36

    See identical proteins and their annotated locations for NP_777559.3

    Status: VALIDATED

    Source sequence(s)
    AC009973, AK123085, BC017869, BC033935, BM997950
    Consensus CDS
    CCDS2472.1
    UniProtKB/Swiss-Prot
    Q8NEA4
    Related
    ENSP00000283946.3, ENST00000283946.8
    Conserved Domains (1) summary
    pfam12937
    Location:94140
    F-box-like; F-box-like

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    229922503..230013913
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005246317.2XP_005246374.1  F-box only protein 36 isoform X1

    Conserved Domains (1) summary
    pfam12937
    Location:69115
    F-box-like; F-box-like
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