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Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 [ Mus musculus (house mouse) ]

Gene ID: 13075, updated on 2-Nov-2024

Summary

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Official Symbol
Cyp19a1provided by MGI
Official Full Name
cytochrome P450, family 19, subfamily a, polypeptide 1provided by MGI
Primary source
MGI:MGI:88587
See related
Ensembl:ENSMUSG00000032274 AllianceGenome:MGI:88587
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ar; ArKO; Int5; Cyp19; Int-5; p450arom
Summary
Enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen. Acts upstream of or within several processes, including negative regulation of macrophage chemotaxis; reproductive structure development; and testosterone biosynthetic process. Predicted to be located in several cellular components, including dendritic spine; neuronal cell body; and synaptic vesicle. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including central nervous system; gonad; gonad primordium; retina; and stomach. Used to study Sjogren's syndrome and aromatase excess syndrome. Human ortholog(s) of this gene implicated in several diseases, including aromatase excess syndrome; bladder neck obstruction; endometriosis (multiple); ovarian disease (multiple); and prostate disease (multiple). Orthologous to human CYP19A1 (cytochrome P450 family 19 subfamily A member 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in ovary adult (RPKM 2.4) and testis adult (RPKM 1.0) See more
Orthologs
human all
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Genomic context

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See Cyp19a1 in Genome Data Viewer
Location:
9 A5.3; 9 29.49 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (54073221..54175448, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (54165937..54268164, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene tumor necrosis factor, alpha-induced protein 8-like 3 Neighboring gene STARR-seq mESC enhancer starr_24161 Neighboring gene STARR-seq mESC enhancer starr_24163 Neighboring gene predicted gene, 57545 Neighboring gene Cyp19a1 promoter I.f Neighboring gene predicted gene, 51676 Neighboring gene putative 60S ribosomal protein L37a Neighboring gene gliomedin, opposite strand Neighboring gene gliomedin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Enhanced urinary odor discrimination in female aromatase knockout (ArKO) mice. Wesson DW, et al. Horm Behav, 2006 May. PMID 16448653, Free PMC Article
  2. Mammalian aromatases. Conley A, et al. Reproduction, 2001 May. PMID 11427156
  3. Aromatase deficiency causes altered expression of molecules critical for calcium reabsorption in the kidneys of female mice *. Oz OK, et al. J Bone Miner Res, 2007 Dec. PMID 17708714
  4. Sexual behavior activity tracks rapid changes in brain estrogen concentrations. Taziaux M, et al. J Neurosci, 2007 Jun 13. PMID 17567817, Free PMC Article
  5. Targeted disruption of the aromatase P450 gene (Cyp19) in mice and their ovarian and uterine responses to 17beta-oestradiol. Toda K, et al. J Endocrinol, 2001 Jul. PMID 11431142

See all (249) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Casein kinase 1alpha mediates estradiol secretion via CYP19A1 expression in mouse ovarian granulosa cells.
    Title: Casein kinase 1α mediates estradiol secretion via CYP19A1 expression in mouse ovarian granulosa cells.
  2. Tripeptidyl peptidase II coordinates the homeostasis of calcium and lipids in the central nervous system and its depletion causes presenile dementia in female mice through calcium/lipid dyshomeostasis-induced autophagic degradation of CYP19A1.
    Title: Tripeptidyl peptidase II coordinates the homeostasis of calcium and lipids in the central nervous system and its depletion causes presenile dementia in female mice through calcium/lipid dyshomeostasis-induced autophagic degradation of CYP19A1.
  3. Overexpression of Estrogen Receptor alpha in Mammary Glands of Aging Mice Is Associated with a Proliferative Risk Signature and Generation of Estrogen Receptor alpha-Positive Mammary Adenocarcinomas.
    Title: Overexpression of Estrogen Receptor α in Mammary Glands of Aging Mice Is Associated with a Proliferative Risk Signature and Generation of Estrogen Receptor α-Positive Mammary Adenocarcinomas.
  4. Esr1 but Not CYP19A1 Overexpression in Mammary Epithelial Cells during Reproductive Senescence Induces Pregnancy-Like Proliferative Mammary Disease Responsive to Anti-Hormonals.
    Title: Esr1 but Not CYP19A1 Overexpression in Mammary Epithelial Cells during Reproductive Senescence Induces Pregnancy-Like Proliferative Mammary Disease Responsive to Anti-Hormonals.
  5. Hippocampal Aromatase Knockdown Aggravates Ovariectomy-Induced Spatial Memory Impairment, Abeta Accumulation and Neural Plasticity Deficiency in Adult Female Mice.
    Title: Hippocampal Aromatase Knockdown Aggravates Ovariectomy-Induced Spatial Memory Impairment, Aβ Accumulation and Neural Plasticity Deficiency in Adult Female Mice.
  6. Brain Aromatase and the Regulation of Sexual Activity in Male Mice.
    Title: Brain Aromatase and the Regulation of Sexual Activity in Male Mice.
  7. Changes in nucleus accumbens gene expression accompany sex-specific suppression of spontaneous physical activity in aromatase knockout mice.
    Title: Changes in nucleus accumbens gene expression accompany sex-specific suppression of spontaneous physical activity in aromatase knockout mice.
  8. Loss of aromatase in hematopoietic cells confers increased skeletal muscle expression of genes implicated in insulin signaling and mitochondrial function.
    Title: Aromatase deficiency in hematopoietic cells improves glucose tolerance in male mice through skeletal muscle-specific effects.
  9. Loss of Cyp19a1 expression results in mild hypospadias.
    Title: A loss of estrogen signaling in the aromatase deficient mouse penis results in mild hypospadias.
  10. data provide evidence of a local increase of aromatase expression by reelin. Regarding reproduction, this crosstalk may contribute to follicular stability and counteract luteinization in ovaries.
    Title: Reelin and aromatase cooperate in ovarian follicle development.
Submit: New GeneRIF Correction See all GeneRIFs (75)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (6) 
  • Targeted (12)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC124251, MGC124252

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables aromatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables aromatase activity ISO
Inferred from Sequence Orthology
more info
  
enables aromatase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables heme binding ISO
Inferred from Sequence Orthology
more info
  
enables heme binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IDA
Inferred from Direct Assay
more info
 PubMed 
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in C21-steroid hormone metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in androgen catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in androgen catabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within androgen metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in androgen metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in calcineurin-mediated signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in estrogen biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within female genitalia development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in female gonad development IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within female gonad development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within mammary gland development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of bone resorption ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of chronic inflammatory response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of macrophage chemotaxis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of estradiol secretion IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of estradiol secretion ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within prostate gland growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of synapse structure or activity ISO
Inferred from Sequence Orthology
more info
  
involved_in response to estradiol IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within testosterone biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within uterus development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in axon terminus ISO
Inferred from Sequence Orthology
more info
  
located_in dendritic spine ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
  
located_in synaptic vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in terminal bouton ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
aromatase
Names
CYPXIX
cytochrome P-450AROM
cytochrome P450 19A1
cytochrome P450, 19, aromatase
estrogen synthase
NP_001335100.1
NP_001335101.1
NP_001335102.1
NP_031836.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001348171.1 → NP_001335100.1  aromatase

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein. Expression of this variant has been found in adipose tissue.
    Source sequence(s)
    AC159816, AC162180
    Consensus CDS
    CCDS23187.1
    UniProtKB/Swiss-Prot
    P28649
    UniProtKB/TrEMBL
    A0A1L1SUD6, Q3ZAT3
    Conserved Domains (1) summary
    pfam00067
    Location:48 → 488
    p450; Cytochrome P450

  2. NM_001348172.1 → NP_001335101.1  aromatase

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein. Expression of this variant has been found in brain.
    Source sequence(s)
    AC159816, AC162180
    Consensus CDS
    CCDS23187.1
    UniProtKB/Swiss-Prot
    P28649
    UniProtKB/TrEMBL
    A0A1L1SUD6, Q3ZAT3
    Conserved Domains (1) summary
    pfam00067
    Location:48 → 488
    p450; Cytochrome P450

  3. NM_001348173.1 → NP_001335102.1  aromatase

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein. Expression of this variant has been found in testis.
    Source sequence(s)
    AC159816, AC162180
    Consensus CDS
    CCDS23187.1
    UniProtKB/Swiss-Prot
    P28649
    UniProtKB/TrEMBL
    A0A1L1SUD6, Q3ZAT3
    Conserved Domains (1) summary
    pfam00067
    Location:48 → 488
    p450; Cytochrome P450

  4. NM_007810.4 → NP_031836.1  aromatase

    See identical proteins and their annotated locations for NP_031836.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3, and 4 encode the same protein. Expression of this variant has been found in gonads.
    Source sequence(s)
    AC159816, AC162180
    Consensus CDS
    CCDS23187.1
    UniProtKB/Swiss-Prot
    P28649
    UniProtKB/TrEMBL
    A0A1L1SUD6, Q3ZAT3
    Related
    ENSMUSP00000034811.8, ENSMUST00000034811.8
    Conserved Domains (1) summary
    pfam00067
    Location:48 → 488
    p450; Cytochrome P450

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    54073221..54175448 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P28649.1 GenPept UniProtKB/Swiss-Prot:P28649

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