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TRABD2A TraB domain containing 2A [ Homo sapiens (human) ]

Gene ID: 129293, updated on 2-Nov-2024

Summary

Official Symbol
TRABD2Aprovided by HGNC
Official Full Name
TraB domain containing 2Aprovided by HGNC
Primary source
HGNC:HGNC:27013
See related
Ensembl:ENSG00000186854 MIM:614912; AllianceGenome:HGNC:27013
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TIKI1; C2orf89
Summary
Enables Wnt-protein binding activity and metalloendopeptidase activity. Involved in negative regulation of Wnt signaling pathway and proteolysis. Located in organelle membrane and plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in colon (RPKM 11.1), ovary (RPKM 8.7) and 9 other tissues See more
Orthologs
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Genomic context

See TRABD2A in Genome Data Viewer
Location:
2p11.2
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (84821666..84881084, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (84823433..84882841, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (85048790..85108208, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene dynein axonemal heavy chain 6 Neighboring gene ubiquitin specific peptidase 26 pseudogene Neighboring gene lactate dehydrogenase A pseudogene 7 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16101 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11687 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:85073645-85074146 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:85074147-85074646 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:85107450-85107952 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:85107953-85108453 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16102 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16103 Neighboring gene uncharacterized LOC105374837 Neighboring gene uncharacterized LOC105374836 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11689 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:85133043-85134242 Neighboring gene ribosomal protein L12 pseudogene 18 Neighboring gene thymosin beta 10

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ46467

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables Wnt-protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables endopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables metalloendopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables metalloendopeptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Process Evidence Code Pubs
involved_in Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in head development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of protein oxidation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in positive regulation of protein-containing complex assembly ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in proteolysis IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in organelle membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
metalloprotease TIKI1
Names
TRAB domain-containing protein 2A
UPF0632 protein C2orf89

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080824.3NP_001074293.1  metalloprotease TIKI1 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001074293.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate coding region exon, compared to variant 1. The resulting protein (isoform 2) is shorter than isoform 1.
    Source sequence(s)
    BC051789, BG170846
    Consensus CDS
    CCDS46349.1
    UniProtKB/Swiss-Prot
    Q86V40
    Related
    ENSP00000335004.5, ENST00000335459.9
    Conserved Domains (1) summary
    pfam01963
    Location:43302
    TraB; TraB family
  2. NM_001277053.2NP_001263982.1  metalloprotease TIKI1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001263982.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC010087
    Consensus CDS
    CCDS62946.1
    UniProtKB/Swiss-Prot
    B4DKK8, I6UMB9, Q86V40
    Related
    ENSP00000387075.2, ENST00000409520.7
    Conserved Domains (1) summary
    pfam01963
    Location:43351
    TraB; TraB family
  3. NM_001307978.2NP_001294907.1  metalloprotease TIKI1 isoform 3 precursor

    See identical proteins and their annotated locations for NP_001294907.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks several exons and includes an alternate 3' terminal exon, compared to variant 1. The resulting protein (isoform 3) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC010087, AK309615, BC049209, BC073808
    Consensus CDS
    CCDS77428.1
    UniProtKB/TrEMBL
    C9IYB5
    Related
    ENSP00000387183.1, ENST00000409133.1
    Conserved Domains (1) summary
    pfam01963
    Location:43331
    TraB; TraB family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    84821666..84881084 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047443257.1XP_047299213.1  metalloprotease TIKI1 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    84823433..84882841 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054340462.1XP_054196437.1  metalloprotease TIKI1 isoform X1

RNA

  1. XR_008486267.1 RNA Sequence