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TRABD2A TraB domain containing 2A [ Homo sapiens (human) ]

Gene ID: 129293, updated on 12-Oct-2019

Summary

Official Symbol
TRABD2Aprovided by HGNC
Official Full Name
TraB domain containing 2Aprovided by HGNC
Primary source
HGNC:HGNC:27013
See related
Ensembl:ENSG00000186854 MIM:614912
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TIKI1; C2orf89
Expression
Biased expression in colon (RPKM 11.1), ovary (RPKM 8.7) and 9 other tissues See more
Orthologs

Genomic context

See TRABD2A in Genome Data Viewer
Location:
2p11.2
Exon count:
9
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (84821650..84881975, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (85048774..85108369, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene dynein axonemal heavy chain 6 Neighboring gene ubiquitin specific peptidase 26 pseudogene Neighboring gene lactate dehydrogenase A pseudogene 7 Neighboring gene uncharacterized LOC105374837 Neighboring gene uncharacterized LOC105374836 Neighboring gene ribosomal protein L12 pseudogene 18 Neighboring gene thymosin beta 10

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General gene information

Markers

Homology

Clone Names

  • FLJ46467

Gene Ontology Provided by GOA

Function Evidence Code Pubs
Wnt-protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Wnt-protein binding IDA
Inferred from Direct Assay
more info
PubMed 
endopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metalloendopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
metalloendopeptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Process Evidence Code Pubs
Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
head development ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein complex assembly ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of protein oxidation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
proteolysis IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
integral component of organelle membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of organelle membrane IDA
Inferred from Direct Assay
more info
PubMed 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
metalloprotease TIKI1
Names
TRAB domain-containing protein 2A
UPF0632 protein C2orf89

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080824.3NP_001074293.1  metalloprotease TIKI1 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001074293.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate coding region exon, compared to variant 1. The resulting protein (isoform 2) is shorter than isoform 1.
    Source sequence(s)
    BC051789, BG170846
    Consensus CDS
    CCDS46349.1
    UniProtKB/Swiss-Prot
    Q86V40
    Related
    ENSP00000335004.5, ENST00000335459.9
    Conserved Domains (1) summary
    pfam01963
    Location:43302
    TraB; TraB family
  2. NM_001277053.2NP_001263982.1  metalloprotease TIKI1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001263982.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC010087
    Consensus CDS
    CCDS62946.1
    UniProtKB/Swiss-Prot
    Q86V40
    Related
    ENSP00000387075.2, ENST00000409520.7
    Conserved Domains (1) summary
    pfam01963
    Location:43351
    TraB; TraB family
  3. NM_001307978.2NP_001294907.1  metalloprotease TIKI1 isoform 3 precursor

    See identical proteins and their annotated locations for NP_001294907.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks several exons and includes an alternate 3' terminal exon, compared to variant 1. The resulting protein (isoform 3) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC010087, AK309615, BC049209, BC073808
    Consensus CDS
    CCDS77428.1
    UniProtKB/Swiss-Prot
    Q86V40
    UniProtKB/TrEMBL
    C9IYB5
    Related
    ENSP00000387183.1, ENST00000409133.1
    Conserved Domains (1) summary
    pfam01963
    Location:43331
    TraB; TraB family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    84821650..84881975 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011532504.1XP_011530806.1  metalloprotease TIKI1 isoform X1

    See identical proteins and their annotated locations for XP_011530806.1

    Conserved Domains (1) summary
    pfam01963
    Location:1248
    TraB; TraB family
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