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Comt catechol-O-methyltransferase [ Mus musculus (house mouse) ]

Gene ID: 12846, updated on 14-Mar-2023

Summary

Official Symbol
Comtprovided by MGI
Official Full Name
catechol-O-methyltransferaseprovided by MGI
Primary source
MGI:MGI:88470
See related
Ensembl:ENSMUSG00000000326 AllianceGenome:MGI:88470
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Comt1; D16Wsu103e; D330014B15Rik
Summary
Enables catechol O-methyltransferase activity. Acts upstream of or within cellular response to phosphate starvation and dopamine catabolic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and sensory organ. Used to study cognitive disorder and pre-eclampsia. Human ortholog(s) of this gene implicated in several diseases, including attention deficit hyperactivity disorder; autoimmune disease of skin and connective tissue (multiple); bulimia nervosa; cognitive disorder (multiple); and reproductive organ cancer (multiple). Orthologous to human COMT (catechol-O-methyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver adult (RPKM 254.4), subcutaneous fat pad adult (RPKM 175.4) and 25 other tissues See more
Orthologs
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Genomic context

See Comt in Genome Data Viewer
Location:
16 A3; 16 11.4 cM
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (18225632..18247006, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (18406882..18426716, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene DGCR8, microprocessor complex subunit Neighboring gene microRNA 3618 Neighboring gene transport and golgi organization 2 Neighboring gene microRNA 185 Neighboring gene armadillo repeat gene deleted in velocardiofacial syndrome Neighboring gene predicted gene 15764 Neighboring gene thioredoxin reductase 2 Neighboring gene guanine nucleotide binding protein (G protein), beta polypeptide 1-like Neighboring gene VISTA enhancer mm321 Neighboring gene predicted gene, 35369 Neighboring gene T-box 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • D330014B15Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables L-dopa O-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables O-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables catechol O-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables catechol O-methyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables catechol O-methyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables orcinol O-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in catecholamine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in catecholamine catabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within catecholamine metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in catecholamine metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cellular response to phosphate starvation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in developmental process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within dopamine catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in dopamine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within dopamine metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in estrogen metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in female pregnancy ISO
Inferred from Sequence Orthology
more info
 
involved_in learning ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in methylation ISO
Inferred from Sequence Orthology
more info
 
involved_in multicellular organismal reproductive process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of dopamine metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of renal sodium excretion ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in neurotransmitter catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in neurotransmitter catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of homocysteine metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of sensory perception of pain ISO
Inferred from Sequence Orthology
more info
 
involved_in response to pain ISO
Inferred from Sequence Orthology
more info
 
involved_in short-term memory ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in axon ISO
Inferred from Sequence Orthology
more info
 
located_in cell body ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in dendritic spine ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
is_active_in postsynapse ISO
Inferred from Sequence Orthology
more info
 
located_in postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
catechol O-methyltransferase
Names
catechol-O-methyltransferase 1
NP_001104532.1
NP_001104533.1
NP_031770.2
XP_036015657.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001111062.1NP_001104532.1  catechol O-methyltransferase

    See identical proteins and their annotated locations for NP_001104532.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1-3 encode the same protein.
    Source sequence(s)
    AC133487, AK148311, AW908224, CX237493
    Consensus CDS
    CCDS28021.1
    UniProtKB/Swiss-Prot
    O88587, Q91XH4
    Related
    ENSMUSP00000000335.5, ENSMUST00000000335.12
    Conserved Domains (1) summary
    cl17173
    Location:60227
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  2. NM_001111063.1NP_001104533.1  catechol O-methyltransferase

    See identical proteins and their annotated locations for NP_001104533.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1-3 encode the same protein.
    Source sequence(s)
    AA250343, AC133487, AK148311, AW908224, GU324998
    Consensus CDS
    CCDS28021.1
    UniProtKB/Swiss-Prot
    O88587, Q91XH4
    Related
    ENSMUSP00000130077.2, ENSMUST00000165430.8
    Conserved Domains (1) summary
    cl17173
    Location:60227
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  3. NM_007744.3NP_031770.2  catechol O-methyltransferase

    See identical proteins and their annotated locations for NP_031770.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1-3 encode the same protein.
    Source sequence(s)
    AC133487, AK148311, AW908224, CX237493
    Consensus CDS
    CCDS28021.1
    UniProtKB/Swiss-Prot
    O88587, Q91XH4
    Related
    ENSMUSP00000111272.3, ENSMUST00000115609.10
    Conserved Domains (1) summary
    cl17173
    Location:60227
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    18225632..18247006 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036159764.1XP_036015657.1  catechol O-methyltransferase isoform X1

    Conserved Domains (1) summary
    COG4122
    Location:5146
    YrrM; Predicted O-methyltransferase YrrM [General function prediction only]