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Comt catechol-O-methyltransferase [ Mus musculus (house mouse) ]

Gene ID: 12846, updated on 14-Mar-2023

Summary

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Official Symbol
Comtprovided by MGI
Official Full Name
catechol-O-methyltransferaseprovided by MGI
Primary source
MGI:MGI:88470
See related
Ensembl:ENSMUSG00000000326 AllianceGenome:MGI:88470
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Comt1; D16Wsu103e; D330014B15Rik
Summary
Enables catechol O-methyltransferase activity. Acts upstream of or within cellular response to phosphate starvation and dopamine catabolic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and sensory organ. Used to study cognitive disorder and pre-eclampsia. Human ortholog(s) of this gene implicated in several diseases, including attention deficit hyperactivity disorder; autoimmune disease of skin and connective tissue (multiple); bulimia nervosa; cognitive disorder (multiple); and reproductive organ cancer (multiple). Orthologous to human COMT (catechol-O-methyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver adult (RPKM 254.4), subcutaneous fat pad adult (RPKM 175.4) and 25 other tissues See more
Orthologs
human all
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Genomic context

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See Comt in Genome Data Viewer
Location:
16 A3; 16 11.4 cM
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (18225632..18247006, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (18406882..18426716, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene DGCR8, microprocessor complex subunit Neighboring gene microRNA 3618 Neighboring gene transport and golgi organization 2 Neighboring gene microRNA 185 Neighboring gene armadillo repeat gene deleted in velocardiofacial syndrome Neighboring gene predicted gene 15764 Neighboring gene thioredoxin reductase 2 Neighboring gene guanine nucleotide binding protein (G protein), beta polypeptide 1-like Neighboring gene VISTA enhancer mm321 Neighboring gene predicted gene, 35369 Neighboring gene T-box 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Dietary Magnesium Insufficiency Induces Salt-Sensitive Hypertension in Mice Associated With Reduced Kidney Catechol-O-Methyl Transferase Activity. Kumagai A, et al. Hypertension, 2021 Jul. PMID 33840199
  2. Heritable Differences in Catecholamine Signaling Modulate Susceptibility to Trauma and Response to Methylphenidate Treatment: Relevance for PTSD. Deslauriers J, et al. Front Behav Neurosci, 2019. PMID 31164811, Free PMC Article
  3. Increased tau phosphorylation follows impeded dopamine clearance in a P301L and novel P301L/COMT-deleted (DM) tau mouse model. Koppel J, et al. J Neurochem, 2019 Jan. PMID 30238463, Free PMC Article
  4. Deficiency in catechol-o-methyltransferase is linked to a disruption of glucose homeostasis in mice. Kanasaki M, et al. Sci Rep, 2017 Aug 11. PMID 28801594, Free PMC Article
  5. Adolescence is the starting point of sex-dichotomous COMT genetic effects. Sannino S, et al. Transl Psychiatry, 2017 May 30. PMID 28556830, Free PMC Article

See all (112) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Dietary Magnesium Insufficiency Induces Salt-Sensitive Hypertension in Mice Associated With Reduced Kidney Catechol-O-Methyl Transferase Activity.
    Title: Dietary Magnesium Insufficiency Induces Salt-Sensitive Hypertension in Mice Associated With Reduced Kidney Catechol-O-Methyl Transferase Activity.
  2. desmocollin-1 (DSC1) is validated as a protein connected with lymph node status of luminal A breast cancer, tumor grade, and Her-2 status and catechol-O-methyltransferase is successfully verified as a protein associated with lymph node metastasis of triple negative breast cancer.
    Title: Proteomics Identification and Validation of Desmocollin-1 and Catechol-O-Methyltransferase as Proteins Associated with Breast Cancer Cell Migration and Metastasis.
  3. These results suggest that COMT is an enzyme to maintain glucose homeostasis and 2-methoxyestradiol is a potential endogenous multi-target anti-diabetic candidate.
    Title: Deficiency in catechol-o-methyltransferase is linked to a disruption of glucose homeostasis in mice.
  4. Miroestrol restored uterine COMT expression in beta-naphthoflavone-treated mice.
    Title: Regulation of cancer-related genes - Cyp1a1, Cyp1b1, Cyp19, Nqo1 and Comt - expression in β-naphthoflavone-treated mice by miroestrol.
  5. This study report that genetically driven reduction in COMT enzyme activity increased cortical thickness in the prefrontal cortex (PFC) and postero-parieto-temporal cortex of male, but not female adult mice.
    Title: COMT Genetic Reduction Produces Sexually Divergent Effects on Cortical Anatomy and Working Memory in Mice and Humans.
  6. COMT expression in the hippocampus was significantly reduced by high E2 replacement, implying increased catecholamine levels in the hippocampus of high E2 mice.
    Title: Estradiol replacement enhances fear memory formation, impairs extinction and reduces COMT expression levels in the hippocampus of ovariectomized female mice.
  7. COMT overexpressing mice display an increase in dopamine release capacity in the striatum, suggesting increased COMT activity may affect dopamine signaling by enhancing synaptic clearance in the cortex and changes in striatal presynaptic dopamine function
    Title: Genetic variation in COMT activity impacts learning and dopamine release capacity in the striatum.
  8. These data confirm at the level of mouse working memory and human working memory-associated physiology a genetic interaction between COMT and DTNBP1.
    Title: Epistatic interaction between COMT and DTNBP1 modulates prefrontal function in mice and in humans.
  9. The results of this study suggest that individual differences in COMT activity do not affect primary reinforcing effects of cocaine in mice.
    Title: [Effect of Catechol-O-methyltransferase deficiency on reinforcing effects of cocaine (experimental study)].
  10. Inhibition of COMT via serotonin binding contributes to pain hypersensitivity.
    Title: Serotonin-induced hypersensitivity via inhibition of catechol O-methyltransferase activity.
Submit: New GeneRIF Correction See all GeneRIFs (27)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • D330014B15Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables L-dopa O-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables O-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables catechol O-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables catechol O-methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables catechol O-methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables orcinol O-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in catecholamine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in catecholamine catabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within catecholamine metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in catecholamine metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cellular response to phosphate starvation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in developmental process IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
acts_upstream_of_or_within dopamine catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in dopamine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
acts_upstream_of_or_within dopamine metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in estrogen metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in female pregnancy ISO
Inferred from Sequence Orthology
more info
  
involved_in learning ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in methylation ISO
Inferred from Sequence Orthology
more info
  
involved_in multicellular organismal reproductive process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of dopamine metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of renal sodium excretion ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in neurotransmitter catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in neurotransmitter catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of homocysteine metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of sensory perception of pain ISO
Inferred from Sequence Orthology
more info
  
involved_in response to pain ISO
Inferred from Sequence Orthology
more info
  
involved_in short-term memory ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in axon ISO
Inferred from Sequence Orthology
more info
  
located_in cell body ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
  
located_in dendritic spine ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 
is_active_in postsynapse ISO
Inferred from Sequence Orthology
more info
  
located_in postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
catechol O-methyltransferase
Names
catechol-O-methyltransferase 1
NP_001104532.1
NP_001104533.1
NP_031770.2
XP_036015657.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001111062.1 → NP_001104532.1  catechol O-methyltransferase

    See identical proteins and their annotated locations for NP_001104532.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1-3 encode the same protein.
    Source sequence(s)
    AC133487, AK148311, AW908224, CX237493
    Consensus CDS
    CCDS28021.1
    UniProtKB/Swiss-Prot
    O88587, Q91XH4
    Related
    ENSMUSP00000000335.5, ENSMUST00000000335.12
    Conserved Domains (1) summary
    cl17173
    Location:60 → 227
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  2. NM_001111063.1 → NP_001104533.1  catechol O-methyltransferase

    See identical proteins and their annotated locations for NP_001104533.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1-3 encode the same protein.
    Source sequence(s)
    AA250343, AC133487, AK148311, AW908224, GU324998
    Consensus CDS
    CCDS28021.1
    UniProtKB/Swiss-Prot
    O88587, Q91XH4
    Related
    ENSMUSP00000130077.2, ENSMUST00000165430.8
    Conserved Domains (1) summary
    cl17173
    Location:60 → 227
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  3. NM_007744.3 → NP_031770.2  catechol O-methyltransferase

    See identical proteins and their annotated locations for NP_031770.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1-3 encode the same protein.
    Source sequence(s)
    AC133487, AK148311, AW908224, CX237493
    Consensus CDS
    CCDS28021.1
    UniProtKB/Swiss-Prot
    O88587, Q91XH4
    Related
    ENSMUSP00000111272.3, ENSMUST00000115609.10
    Conserved Domains (1) summary
    cl17173
    Location:60 → 227
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    18225632..18247006 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036159764.1 → XP_036015657.1  catechol O-methyltransferase isoform X1

    Conserved Domains (1) summary
    COG4122
    Location:5 → 146
    YrrM; Predicted O-methyltransferase YrrM [General function prediction only]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O88587.2 GenPept UniProtKB/Swiss-Prot:O88587

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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