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These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in Genomic regions,
transcripts, and products above.
Genomic
-
NG_011526.1 RefSeqGene
- Range
-
5001..33236
- Download
- GenBank, FASTA, Sequence Viewer (Graphics), LRG_1010
mRNA and Protein(s)
-
NM_000754.4 → NP_000745.1 catechol O-methyltransferase isoform MB-COMT
See identical proteins and their annotated locations for NP_000745.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (1, also known as MB-COMT) represents the predominant transcript and encodes the longer isoform (MB-COMT). Variants 1, 2, 3, and 5 all encode isoform MB-COMT and may also make the shorter isoform S-COMT at a low level. MB-COMT is a membrane-bound protein.
- Source sequence(s)
-
AC005663, AK290440, BX461394
- Consensus CDS
-
CCDS13770.1
- UniProtKB/Swiss-Prot
- P21964, Q9BWC7
- UniProtKB/TrEMBL
-
A0A140VJG8
- Related
- ENSP00000354511.6, ENST00000361682.11
- Conserved Domains (1) summary
-
- COG4122
Location:51 → 264
- YrrM; Predicted O-methyltransferase YrrM [General function prediction only]
-
NM_001135161.2 → NP_001128633.1 catechol O-methyltransferase isoform MB-COMT
See identical proteins and their annotated locations for NP_001128633.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, and 5 all encode isoform MB-COMT and may also make the shorter isoform S-COMT at a low level. MB-COMT is a membrane-bound protein.
- Source sequence(s)
-
AC005663, AK290440, BE386545
- Consensus CDS
-
CCDS13770.1
- UniProtKB/Swiss-Prot
- P21964, Q9BWC7
- UniProtKB/TrEMBL
-
A0A140VJG8
- Related
- ENSP00000403958.1, ENST00000412786.5
- Conserved Domains (1) summary
-
- COG4122
Location:51 → 264
- YrrM; Predicted O-methyltransferase YrrM [General function prediction only]
-
NM_001135162.2 → NP_001128634.1 catechol O-methyltransferase isoform MB-COMT
See identical proteins and their annotated locations for NP_001128634.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, and 5 all encode isoform MB-COMT and may also make the shorter isoform S-COMT at a low level. MB-COMT is a membrane-bound protein.
- Source sequence(s)
-
AC005663, AK290440, BE728779
- Consensus CDS
-
CCDS13770.1
- UniProtKB/Swiss-Prot
- P21964, Q9BWC7
- UniProtKB/TrEMBL
-
A0A140VJG8
- Related
- ENSP00000385150.3, ENST00000406520.7
- Conserved Domains (1) summary
-
- COG4122
Location:51 → 264
- YrrM; Predicted O-methyltransferase YrrM [General function prediction only]
-
NM_001362828.2 → NP_001349757.1 catechol O-methyltransferase isoform MB-COMT
Status: REVIEWED
- Description
- Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, and 5 all encode isoform MB-COMT and may also make the shorter isoform S-COMT at a low level. MB-COMT is a membrane-bound protein.
- Source sequence(s)
-
AC000090, AC005663
- Consensus CDS
-
CCDS13770.1
- UniProtKB/Swiss-Prot
-
Q9BWC7
- UniProtKB/TrEMBL
-
A0A140VJG8
- Related
- ENSP00000385917.1, ENST00000403710.5
- Conserved Domains (1) summary
-
- COG4122
Location:51 → 264
- YrrM; Predicted O-methyltransferase YrrM [General function prediction only]
-
NM_007310.3 → NP_009294.1 catechol O-methyltransferase isoform S-COMT
See identical proteins and their annotated locations for NP_009294.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (4, also known as S-COMT) contains a shorter 5' UTR and a translation start site which lies 50 codons downstream compared to that of variant 1. The resulting isoform (S-COMT) is shorter at the N-terminus compared to isoform MB-COMT. S-COMT is a soluble protein.
- Source sequence(s)
-
AC005663, AK290440
- Consensus CDS
-
CCDS46663.1
- UniProtKB/Swiss-Prot
-
P21964
- Related
- ENSP00000416778.1, ENST00000449653.5
- Conserved Domains (1) summary
-
- COG4122
Location:1 → 177
- YrrM; Predicted O-methyltransferase YrrM [General function prediction only]
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as
RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate
assemblies. Model RNAs and proteins are also reported here.
Reference GRCh38.p14 Primary Assembly
Genomic
-
NC_000022.11 Reference GRCh38.p14 Primary Assembly
- Range
-
19941772..19969975
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
Alternate T2T-CHM13v2.0
Genomic
-
NC_060946.1 Alternate T2T-CHM13v2.0
- Range
-
20319463..20347602
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)