U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Plk3 polo like kinase 3 [ Mus musculus (house mouse) ]

Gene ID: 12795, updated on 27-Feb-2024

Summary

Official Symbol
Plk3provided by MGI
Official Full Name
polo like kinase 3provided by MGI
Primary source
MGI:MGI:109604
See related
Ensembl:ENSMUSG00000028680 AllianceGenome:MGI:109604
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cnk; Fnk; PRK; PLK-3
Summary
This gene encodes a member of the highly conserved polo-like kinase family of serine/threonine kinases. Members of this family are characterized by an amino-terminal catalytic domain and a carboxy-terminal bipartite polo box domain that functions as a substrate-binding motif and a cellular localization signal. Polo-like kinases have primarily been implicated in cell cycle regulation. In mouse, this protein that has been reported to localize to the nucleolus during interphase but is undetectable during mitosis, following nucleolus dissociation during prophase. The protein relocalizes to the nucleolus just prior to cytokinesis and peak levels are detected during G1 of interphase. This gene has been implicated in regulation of entry into S phase, with RNAi-induced depletion resulting in failure to re-enter the cell cycle. Mice deficient for this gene exhibit increased weight and tumor development at advanced age. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
Expression
Ubiquitous expression in colon adult (RPKM 33.3), stomach adult (RPKM 16.7) and 24 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Plk3 in Genome Data Viewer
Location:
4 D1; 4 53.41 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (116985852..116991244, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (117128655..117133963, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene Ptch2 Hedgehog-responsive enhancers Neighboring gene patched 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:116793139-116793326 Neighboring gene BTB domain containing 19 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:116797070-116797223 Neighboring gene dynein light chain Tctex-type 4 Neighboring gene STARR-positive B cell enhancer ABC_E2707 Neighboring gene STARR-positive B cell enhancer ABC_E7981 Neighboring gene bestrophin 4, pseudogene Neighboring gene polymerase (RNA) II (DNA directed) polypeptide L pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (4)  1 citation
  • Endonuclease-mediated (5) 

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables p53 binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in DNA damage response IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in DNA damage response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
 
involved_in G1/S transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in Golgi disassembly IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in Golgi disassembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in cytoplasmic microtubule organization ISO
Inferred from Sequence Orthology
more info
 
involved_in mitotic G1/S transition checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mitotic G1/S transition checkpoint signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitotic spindle organization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of chaperone-mediated autophagy ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of intracellular protein transport ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of cell division ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cytokinesis ISO
Inferred from Sequence Orthology
more info
 
involved_in response to osmotic stress ISO
Inferred from Sequence Orthology
more info
 
involved_in response to radiation ISO
Inferred from Sequence Orthology
more info
 
involved_in response to reactive oxygen species ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
located_in Golgi stack ISO
Inferred from Sequence Orthology
more info
 
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
part_of chromatin IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
is_active_in kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
is_active_in spindle pole IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
serine/threonine-protein kinase PLK3
Names
FGF-inducible kinase
cytokine-inducible serine/threonine-protein kinase
NP_001300845.1
NP_038835.2
XP_036019516.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001313916.1NP_001300845.1  serine/threonine-protein kinase PLK3 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AL671866, BC063051
    UniProtKB/Swiss-Prot
    Q60806, Q60822, Q9R009
    Related
    ENSMUSP00000120476.2, ENSMUST00000147730.2
    Conserved Domains (4) summary
    smart00220
    Location:63315
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd13117
    Location:546613
    POLO_box_2; Second polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5
    cd13118
    Location:445533
    POLO_box_1; First polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5
    cd14189
    Location:61315
    STKc_PLK3; Catalytic domain of the Serine/Threonine Kinase, Polo-like kinase 3
  2. NM_013807.3NP_038835.2  serine/threonine-protein kinase PLK3 isoform 1

    See identical proteins and their annotated locations for NP_038835.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL671866, BC063051
    Consensus CDS
    CCDS18529.1
    UniProtKB/TrEMBL
    Q3U0L5, Q6P571
    Related
    ENSMUSP00000076130.6, ENSMUST00000076859.12
    Conserved Domains (4) summary
    smart00220
    Location:63315
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd13117
    Location:563630
    POLO_box_2; Second polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5
    cd13118
    Location:462550
    POLO_box_1; First polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5
    cd14189
    Location:61315
    STKc_PLK3; Catalytic domain of the Serine/Threonine Kinase, Polo-like kinase 3

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    116985852..116991244 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036163623.1XP_036019516.1  serine/threonine-protein kinase PLK3 isoform X1

    UniProtKB/TrEMBL
    I6L9A2
    Conserved Domains (1) summary
    cl21453
    Location:61315
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. XR_004941805.1 RNA Sequence