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PLK3 polo like kinase 3 [ Homo sapiens (human) ]

Gene ID: 1263, updated on 13-Mar-2020

Summary

Official Symbol
PLK3provided by HGNC
Official Full Name
polo like kinase 3provided by HGNC
Primary source
HGNC:HGNC:2154
See related
Ensembl:ENSG00000173846 MIM:602913
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CNK; FNK; PRK; PLK-3
Summary
The protein encoded by this gene is a member of the highly conserved polo-like kinase family of serine/threonine kinases. Members of this family are characterized by an amino-terminal kinase domain and a carboxy-terminal bipartite polo box domain that functions as a substrate-binding motif and a cellular localization signal. Polo-like kinases are important regulators of cell cycle progression. This gene has also been implicated in stress responses and double-strand break repair. In human cell lines, this protein is reported to associate with centrosomes in a microtubule-dependent manner, and during mitosis, the protein becomes localized to the mitotic apparatus. Expression of a kinase-defective mutant results in abnormal cell morphology caused by changes in microtubule dynamics and mitotic arrest followed by apoptosis. [provided by RefSeq, Sep 2015]
Expression
Ubiquitous expression in bone marrow (RPKM 16.1), gall bladder (RPKM 12.7) and 25 other tissues See more
Orthologs

Genomic context

See PLK3 in Genome Data Viewer
Location:
1p34.1
Exon count:
15
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (44799952..44805995)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (45265638..45271667)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein S15a pseudogene 11 Neighboring gene bestrophin 4 Neighboring gene Tctex1 domain containing 4 Neighboring gene BTB domain containing 19 Neighboring gene uncharacterized LOC107984952 Neighboring gene RNA, U5E small nuclear 6, pseudogene Neighboring gene patched 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
p53 binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS
Traceable Author Statement
more info
 
G1/S transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
G2/M transition of mitotic cell cycle TAS
Traceable Author Statement
more info
PubMed 
Golgi disassembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Golgi disassembly IDA
Inferred from Direct Assay
more info
PubMed 
apoptotic process TAS
Traceable Author Statement
more info
PubMed 
cellular response to DNA damage stimulus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to DNA damage stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to DNA damage stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
cytoplasmic microtubule organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
endomitotic cell cycle TAS
Traceable Author Statement
more info
PubMed 
mitotic G1/S transition checkpoint IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitotic G1/S transition checkpoint ISS
Inferred from Sequence or Structural Similarity
more info
 
mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitotic cell cycle checkpoint TAS
Traceable Author Statement
more info
PubMed 
negative regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of chaperone-mediated autophagy IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of intracellular protein transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia IDA
Inferred from Direct Assay
more info
PubMed 
protein kinase B signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
regulation of cell division IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of cytokinesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cytokinesis TAS
Traceable Author Statement
more info
PubMed 
regulation of signal transduction by p53 class mediator TAS
Traceable Author Statement
more info
 
response to osmotic stress IDA
Inferred from Direct Assay
more info
PubMed 
response to radiation IDA
Inferred from Direct Assay
more info
PubMed 
response to reactive oxygen species IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
Golgi stack IDA
Inferred from Direct Assay
more info
PubMed 
centrosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
dendrite IEA
Inferred from Electronic Annotation
more info
 
neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
spindle pole IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
serine/threonine-protein kinase PLK3
Names
FGF-inducible kinase
cytokine-inducible serine/threonine-protein kinase
proliferation-related kinase
NP_004064.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004073.4NP_004064.2  serine/threonine-protein kinase PLK3

    See identical proteins and their annotated locations for NP_004064.2

    Status: REVIEWED

    Source sequence(s)
    BC013899, BC013960
    Consensus CDS
    CCDS515.1
    UniProtKB/Swiss-Prot
    Q9H4B4
    Related
    ENSP00000361275.4, ENST00000372201.5
    Conserved Domains (4) summary
    smart00220
    Location:62314
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd13117
    Location:561628
    POLO_box_2; Second polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5
    cd13118
    Location:460548
    POLO_box_1; First polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5
    cd14189
    Location:60314
    STKc_PLK3; Catalytic domain of the Serine/Threonine Kinase, Polo-like kinase 3

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    44799952..44805995
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_246234.4 RNA Sequence

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