U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

FBXO27 F-box protein 27 [ Homo sapiens (human) ]

Gene ID: 126433, updated on 13-May-2022

Summary

Official Symbol
FBXO27provided by HGNC
Official Full Name
F-box protein 27provided by HGNC
Primary source
HGNC:HGNC:18753
See related
Ensembl:ENSG00000161243 MIM:609099; AllianceGenome:HGNC:18753
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FBG5; Fbx27
Summary
Members of the F-box protein family, such as FBXO27, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
Expression
Broad expression in skin (RPKM 7.0), fat (RPKM 5.3) and 21 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See FBXO27 in Genome Data Viewer
Location:
19q13.2
Exon count:
9
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (39005842..39032549, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (41827979..41836507, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (39514661..39523189, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904713 Neighboring gene F-box protein 17 Neighboring gene small nucleolar RNA U13 Neighboring gene acid phosphatase 7, tartrate resistant (putative)

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in glycoprotein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
involved_in ubiquitin-dependent ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
part_of SCF ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of SCF ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
F-box only protein 27
Names
F-box protein FBG5
F-box/G-domain protein 5
epididymis secretory sperm binding protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178820.5NP_849142.1  F-box only protein 27

    See identical proteins and their annotated locations for NP_849142.1

    Status: VALIDATED

    Source sequence(s)
    AC010605, AF436061, BC014527, BX377760
    Consensus CDS
    CCDS12527.1
    UniProtKB/Swiss-Prot
    Q8NI29
    Related
    ENSP00000292853.3, ENST00000292853.9
    Conserved Domains (2) summary
    pfam04300
    Location:105278
    FBA; F-box associated region
    pfam12937
    Location:3967
    F-box-like

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    39005842..39032549 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017026290.2XP_016881779.1  F-box only protein 27 isoform X3

  2. XM_047438172.1XP_047294128.1  F-box only protein 27 isoform X1

  3. XM_047438173.1XP_047294129.1  F-box only protein 27 isoform X1

  4. XM_047438174.1XP_047294130.1  F-box only protein 27 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    41827979..41836507 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)