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Fbxo27 F-box protein 27 [ Mus musculus (house mouse) ]

Gene ID: 233040, updated on 2-Nov-2024

Summary

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Official Symbol
Fbxo27provided by MGI
Official Full Name
F-box protein 27provided by MGI
Primary source
MGI:MGI:2685007
See related
Ensembl:ENSMUSG00000037463 AllianceGenome:MGI:2685007
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
FBG5; Gm161; E130008B10Rik
Summary
Predicted to contribute to ubiquitin protein ligase activity. Predicted to be involved in ERAD pathway; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; and glycoprotein catabolic process. Predicted to be part of SCF ubiquitin ligase complex. Predicted to be active in cytoplasm. Is expressed in central nervous system; neural retinal epithelium; retina inner nuclear layer; retina nuclear layer; and retina outer nuclear layer. Orthologous to human FBXO27 (F-box protein 27). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in cerebellum adult (RPKM 9.8), placenta adult (RPKM 8.9) and 19 other tissues See more
Orthologs
human all
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Genomic context

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See Fbxo27 in Genome Data Viewer
Location:
7 B1; 7 16.89 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (28392205..28398763)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (28692780..28699338)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene microRNA 7049 Neighboring gene p21 (RAC1) activated kinase 4 Neighboring gene STARR-seq mESC enhancer starr_18428 Neighboring gene STARR-seq mESC enhancer starr_18429 Neighboring gene acid phosphatase 7, tartrate resistant Neighboring gene STARR-seq mESC enhancer starr_18430 Neighboring gene STARR-seq mESC enhancer starr_18432 Neighboring gene STARR-seq mESC enhancer starr_18434 Neighboring gene F-box protein 17 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:29526699-29526882 Neighboring gene mitochondrial ribosomal protein S12

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The CREG1-FBXO27-LAMP2 axis alleviates diabetic cardiomyopathy by promoting autophagy in cardiomyocytes. Liu D, et al. Exp Mol Med, 2023 Sep. PMID 37658156, Free PMC Article
  2. Systematic analysis and nomenclature of mammalian F-box proteins. Jin J, et al. Genes Dev, 2004 Nov 1. PMID 15520277, Free PMC Article
  3. Genomic analysis of mouse retinal development. Blackshaw S, et al. PLoS Biol, 2004 Sep. PMID 15226823, Free PMC Article
  4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The CREG1-FBXO27-LAMP2 axis alleviates diabetic cardiomyopathy by promoting autophagy in cardiomyocytes.
    Title: The CREG1-FBXO27-LAMP2 axis alleviates diabetic cardiomyopathy by promoting autophagy in cardiomyocytes.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding ISS
Inferred from Sequence or Structural Similarity
more info
  
contributes_to ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycoprotein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of SCF ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SCF ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  
part_of SCF ubiquitin ligase complex ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
F-box only protein 27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163702.1 → NP_001157174.1  F-box only protein 27 isoform 1

    See identical proteins and their annotated locations for NP_001157174.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK158463, BQ033399
    Consensus CDS
    CCDS52164.1
    UniProtKB/Swiss-Prot
    Q3TYP0, Q6DIA9, Q8BKF7
    Related
    ENSMUSP00000103916.2, ENSMUST00000108281.8
    Conserved Domains (2) summary
    pfam04300
    Location:102 → 273
    FBA; F-box associated region
    pfam12937
    Location:37 → 64
    F-box-like

  2. NM_001355157.1 → NP_001342086.1  F-box only protein 27 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC109162
    Consensus CDS
    CCDS52164.1
    UniProtKB/Swiss-Prot
    Q3TYP0, Q6DIA9, Q8BKF7
    Conserved Domains (2) summary
    pfam04300
    Location:102 → 273
    FBA; F-box associated region
    pfam12937
    Location:37 → 64
    F-box-like

  3. NM_001384172.1 → NP_001371101.1  F-box only protein 27 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC109162
    Conserved Domains (2) summary
    pfam04300
    Location:125 → 298
    FBA; F-box associated region
    pfam12937
    Location:60 → 87
    F-box-like

  4. NM_207238.3 → NP_997121.1  F-box only protein 27 isoform 2

    See identical proteins and their annotated locations for NP_997121.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1.
    Source sequence(s)
    AK053292, BQ033399
    Consensus CDS
    CCDS21051.1
    UniProtKB/Swiss-Prot
    Q6DIA9
    Related
    ENSMUSP00000038432.5, ENSMUST00000039998.11
    Conserved Domains (2) summary
    pfam04300
    Location:104 → 274
    FBA; F-box associated region
    pfam12937
    Location:37 → 64
    F-box-like; F-box-like

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    28392205..28398763
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006539865.4 → XP_006539928.1  F-box only protein 27 isoform X2

    Conserved Domains (2) summary
    pfam04300
    Location:168 → 299
    FBA; F-box associated region
    pfam12937
    Location:103 → 130
    F-box-like

  2. XM_006539862.4 → XP_006539925.1  F-box only protein 27 isoform X1

    Conserved Domains (2) summary
    pfam04300
    Location:168 → 339
    FBA; F-box associated region
    pfam12937
    Location:103 → 130
    F-box-like

  3. XM_006539867.5 → XP_006539930.1  F-box only protein 27 isoform X3

    See identical proteins and their annotated locations for XP_006539930.1

    UniProtKB/Swiss-Prot
    Q3TYP0, Q6DIA9, Q8BKF7
    Conserved Domains (2) summary
    pfam04300
    Location:102 → 273
    FBA; F-box associated region
    pfam12937
    Location:37 → 64
    F-box-like
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6DIA9.1 GenPept UniProtKB/Swiss-Prot:Q6DIA9

Gene LinkOut

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