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Fbxo27 F-box protein 27 [ Mus musculus (house mouse) ]

Gene ID: 233040, updated on 5-Mar-2024

Summary

Official Symbol
Fbxo27provided by MGI
Official Full Name
F-box protein 27provided by MGI
Primary source
MGI:MGI:2685007
See related
Ensembl:ENSMUSG00000037463 AllianceGenome:MGI:2685007
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
FBG5; Gm161; E130008B10Rik
Summary
Predicted to contribute to ubiquitin protein ligase activity. Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; glycoprotein catabolic process; and ubiquitin-dependent ERAD pathway. Predicted to be part of SCF ubiquitin ligase complex. Predicted to be active in cytoplasm. Is expressed in central nervous system; neural retinal epithelium; retina inner nuclear layer; retina nuclear layer; and retina outer nuclear layer. Orthologous to human FBXO27 (F-box protein 27). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cerebellum adult (RPKM 9.8), placenta adult (RPKM 8.9) and 19 other tissues See more
Orthologs
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Genomic context

See Fbxo27 in Genome Data Viewer
Location:
7 B1; 7 16.89 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (28392205..28398763)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (28692780..28699338)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene microRNA 7049 Neighboring gene p21 (RAC1) activated kinase 4 Neighboring gene STARR-seq mESC enhancer starr_18428 Neighboring gene STARR-seq mESC enhancer starr_18429 Neighboring gene acid phosphatase 7, tartrate resistant Neighboring gene STARR-seq mESC enhancer starr_18430 Neighboring gene STARR-seq mESC enhancer starr_18432 Neighboring gene STARR-seq mESC enhancer starr_18434 Neighboring gene F-box protein 17 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:29526699-29526882 Neighboring gene mitochondrial ribosomal protein S12

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in glycoprotein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
part_of SCF ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of SCF ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163702.1NP_001157174.1  F-box only protein 27 isoform 1

    See identical proteins and their annotated locations for NP_001157174.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK158463, BQ033399
    Consensus CDS
    CCDS52164.1
    UniProtKB/Swiss-Prot
    Q3TYP0, Q6DIA9, Q8BKF7
    Related
    ENSMUSP00000103916.2, ENSMUST00000108281.8
    Conserved Domains (2) summary
    pfam04300
    Location:102273
    FBA; F-box associated region
    pfam12937
    Location:3764
    F-box-like
  2. NM_001355157.1NP_001342086.1  F-box only protein 27 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC109162
    Consensus CDS
    CCDS52164.1
    UniProtKB/Swiss-Prot
    Q3TYP0, Q6DIA9, Q8BKF7
    Conserved Domains (2) summary
    pfam04300
    Location:102273
    FBA; F-box associated region
    pfam12937
    Location:3764
    F-box-like
  3. NM_001384172.1NP_001371101.1  F-box only protein 27 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC109162
    Conserved Domains (2) summary
    pfam04300
    Location:125298
    FBA; F-box associated region
    pfam12937
    Location:6087
    F-box-like
  4. NM_207238.3NP_997121.1  F-box only protein 27 isoform 2

    See identical proteins and their annotated locations for NP_997121.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1.
    Source sequence(s)
    AK053292, BQ033399
    Consensus CDS
    CCDS21051.1
    UniProtKB/Swiss-Prot
    Q6DIA9
    Related
    ENSMUSP00000038432.5, ENSMUST00000039998.11
    Conserved Domains (2) summary
    pfam04300
    Location:104274
    FBA; F-box associated region
    pfam12937
    Location:3764
    F-box-like; F-box-like

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    28392205..28398763
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006539865.4XP_006539928.1  F-box only protein 27 isoform X2

    Conserved Domains (2) summary
    pfam04300
    Location:168299
    FBA; F-box associated region
    pfam12937
    Location:103130
    F-box-like
  2. XM_006539862.4XP_006539925.1  F-box only protein 27 isoform X1

    Conserved Domains (2) summary
    pfam04300
    Location:168339
    FBA; F-box associated region
    pfam12937
    Location:103130
    F-box-like
  3. XM_006539867.5XP_006539930.1  F-box only protein 27 isoform X3

    See identical proteins and their annotated locations for XP_006539930.1

    UniProtKB/Swiss-Prot
    Q3TYP0, Q6DIA9, Q8BKF7
    Conserved Domains (2) summary
    pfam04300
    Location:102273
    FBA; F-box associated region
    pfam12937
    Location:3764
    F-box-like