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NTN5 netrin 5 [ Homo sapiens (human) ]

Gene ID: 126147, updated on 9-Jun-2025
Official Symbol
NTN5provided by HGNC
Official Full Name
netrin 5provided by HGNC
Primary source
HGNC:HGNC:25208
See related
Ensembl:ENSG00000142233 AllianceGenome:HGNC:25208
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to be involved in neurogenesis. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Jun 2025]
Expression
Low expression observed in reference dataset See more
Orthologs
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See NTN5 in Genome Data Viewer
Location:
19q13.33
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (48661407..48673017, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (51655875..51667423, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (49164664..49176274, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene sphingosine kinase 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10890 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10891 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10892 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10893 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10894 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10895 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14904 Neighboring gene D-box binding PAR bZIP transcription factor Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr19:49147372-49148073 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:49148074-49148774 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:49148775-49149475 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10896 Neighboring gene secretory blood group 1, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10897 Neighboring gene carbonic anhydrase 11 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:49166921-49167422 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:49167423-49167922 Neighboring gene uncharacterized LOC105372431 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr19:49177831-49178479 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:49178480-49179127 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:49185967-49186241 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:49198499-49199062 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:49199627-49200190 Neighboring gene uncharacterized LOC105447645 Neighboring gene fucosyltransferase 2 (H blood group)

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

EBI GWAS Catalog

Description
Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.
EBI GWAS Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in nervous system development IEA
Inferred from Electronic Annotation
more info
 
involved_in neurogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
netrin-5
Names
netrin-1-like protein

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145807.4NP_665806.1  netrin-5 precursor

    See identical proteins and their annotated locations for NP_665806.1

    Status: VALIDATED

    Source sequence(s)
    AC008888
    Consensus CDS
    CCDS33068.1
    UniProtKB/Swiss-Prot
    Q8N4X9, Q8WTR8, Q8WU63
    Related
    ENSP00000270235.4, ENST00000270235.11
    Conserved Domains (2) summary
    cd00055
    Location:274323
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd03579
    Location:360475
    NTR_netrin-1_like; NTR domain, Netrin-1-like subfamily; The C-terminal NTR domain of netrins is also called domain C in the context of C. elegans netrin UNC-6. Netrins are secreted proteins that function as tropic cues in the direction of axon growth and cell migration ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    48661407..48673017 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011526443.4XP_011524745.1  netrin-5 isoform X1

    Conserved Domains (1) summary
    cd00055
    Location:274323
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    51655875..51667423 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054319787.1XP_054175762.1  netrin-5 isoform X1