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Cdk7 cyclin dependent kinase 7 [ Mus musculus (house mouse) ]

Gene ID: 12572, updated on 8-Feb-2024

Summary

Official Symbol
Cdk7provided by MGI
Official Full Name
cyclin dependent kinase 7provided by MGI
Primary source
MGI:MGI:102956
See related
Ensembl:ENSMUSG00000069089 AllianceGenome:MGI:102956
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CAK; Crk4; Cdkn7; P39 Mo15; C230069N13
Summary
Enables protein kinase activity. Predicted to be involved in protein stabilization; regulation of transcription by RNA polymerase II; and transcription initiation from RNA polymerase II promoter. Predicted to act upstream of or within DNA repair; cell division; and phosphorylation. Located in nucleus. Is expressed in embryo and future hindbrain. Orthologous to human CDK7 (cyclin dependent kinase 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in limb E14.5 (RPKM 5.1), placenta adult (RPKM 4.4) and 28 other tissues See more
Orthologs
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Genomic context

See Cdk7 in Genome Data Viewer
Location:
13 D1; 13 53.23 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (100833532..100867454, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (100697024..100730942, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene RAD17 checkpoint clamp loader component Neighboring gene STARR-positive B cell enhancer ABC_E7268 Neighboring gene TATA-box binding protein associated factor 9 Neighboring gene adenylate kinase 6 Neighboring gene STARR-seq mESC enhancer starr_35476 Neighboring gene coiled-coil domain containing 125 Neighboring gene STARR-seq mESC enhancer starr_35477 Neighboring gene STARR-positive B cell enhancer ABC_E7269 Neighboring gene STARR-positive B cell enhancer mm9_chr13:101513935-101514236 Neighboring gene mitochondrial ribosomal protein S36 Neighboring gene centromere protein H

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (3)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP-dependent activity, acting on DNA ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II CTD heptapeptide repeat kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA polymerase II CTD heptapeptide repeat kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables cyclin-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cyclin-dependent protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables cyclin-dependent protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in protein stabilization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of G1/S transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in transcription initiation at RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of CAK-ERCC2 complex ISO
Inferred from Sequence Orthology
more info
 
part_of cyclin-dependent protein kinase activating kinase holoenzyme complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
 
located_in male germ cell nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of transcription factor TFIIH core complex ISO
Inferred from Sequence Orthology
more info
 
part_of transcription factor TFIIH holo complex ISO
Inferred from Sequence Orthology
more info
 
part_of transcription factor TFIIK complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of transcription factor TFIIK complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
cyclin-dependent kinase 7
Names
39 kDa protein kinase
CDK-activating kinase
CR4 protein kinase
CRK4 PK (CDC2-related-kinase-4 protein kinase)
TFIIH basal transcription factor complex kinase subunit
cell division protein kinase 7
cyclin-dependent kinase 7 (homolog of Xenopus MO15 cdk-activating kinase)
protein-tyrosine kinase MPK-7
NP_034004.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009874.4NP_034004.2  cyclin-dependent kinase 7

    See identical proteins and their annotated locations for NP_034004.2

    Status: VALIDATED

    Source sequence(s)
    AC165159
    Consensus CDS
    CCDS36766.1
    UniProtKB/Swiss-Prot
    Q03147, Q99KK3
    UniProtKB/TrEMBL
    A0A286YDC0, Q3THG5
    Related
    ENSMUSP00000088845.7, ENSMUST00000091299.8
    Conserved Domains (2) summary
    PTZ00024
    Location:7308
    PTZ00024; cyclin-dependent protein kinase; Provisional
    cd07841
    Location:11308
    STKc_CDK7; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 7

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    100833532..100867454 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)