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CDK7 cyclin dependent kinase 7 [ Homo sapiens (human) ]

Gene ID: 1022, updated on 7-Dec-2018

Summary

Official Symbol
CDK7provided by HGNC
Official Full Name
cyclin dependent kinase 7provided by HGNC
Primary source
HGNC:HGNC:1778
See related
Ensembl:ENSG00000134058 MIM:601955
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CAK; CAK1; HCAK; MO15; STK1; CDKN7; p39MO15
Summary
The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This protein forms a trimeric complex with cyclin H and MAT1, which functions as a Cdk-activating kinase (CAK). It is an essential component of the transcription factor TFIIH, that is involved in transcription initiation and DNA repair. This protein is thought to serve as a direct link between the regulation of transcription and the cell cycle. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 18.1), placenta (RPKM 14.9) and 25 other tissues See more
Orthologs

Genomic context

See CDK7 in Genome Data Viewer
Location:
5q13.2
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 5 NC_000005.10 (69234795..69277430)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (68530622..68573257)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene centromere protein H Neighboring gene mitochondrial ribosomal protein S36 Neighboring gene coiled-coil domain containing 125 Neighboring gene cofilin 1 pseudogene 5 Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 2 pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat interacts with the RNA polymerase II holoenzyme and transcription preinitiation complexes, which include TFIIH, during Tat-mediated transactivation of the HIV-1 LTR PubMed
tat TFIIH subunits CDK7 and cyclin H have been identified as two components associated with the Tat-associated CTD kinase (TTK) that binds to HIV-1 Tat PubMed
tat Phosphorylation of CDK7 by CDK2 is involved in the interaction of HIV-1 Tat with CDK7 and subsequent activation of HIV-1 transactivation of the HIV-1 LTR promoter PubMed
tat TFIIH synergizes with HIV-1 Tat to induce transcription elongation from the HIV-1 LTR promoter PubMed
tat Interaction of HIV-1 Tat with TFIIH stimulates phosphorylation of Ser-5 of the RNA polymerase II C-terminal domain (CTD), which in turn also stimulates co-transcriptional capping of HIV-1 mRNA PubMed
tat TFIIH interacts with HIV-1 Tat as a component of the HIV-1 transcription preinitiation complex, but is released from the elongation complex which includes P-TEFb PubMed
tat CAK/TFIIH is required for HIV-1 Tat-mediated transactivation of the HIV-1 LTR promoter PubMed
tat Amino acids 1-48 of HIV-1 Tat, which includes the Tat activation domain, mediate the binding of Tat to CAK and the TFIIH complex through a direct interaction with CDK7 and possibly other TFIIH subunits, including p62 and ERCC3 PubMed
Vpr vpr As a component of the TFIIH transcription complex, CDK7 inhibits HIV-1 Vpr cell cycle-arresting function PubMed
vpr As a component of the TFIIH transcription complex, CDK7 enhances the synergistic activation of glucocorticoid receptor by HIV-1 Vpr and p300 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
DNA-dependent ATPase activity IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II CTD heptapeptide repeat kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
androgen receptor binding NAS
Non-traceable Author Statement
more info
PubMed 
cyclin-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
kinase activity TAS
Traceable Author Statement
more info
 
protein C-terminus binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity TAS
Traceable Author Statement
more info
PubMed 
protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
 
transcription coactivator activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
7-methylguanosine mRNA capping TAS
Traceable Author Statement
more info
 
androgen receptor signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
cell cycle arrest TAS
Traceable Author Statement
more info
PubMed 
cell division IEA
Inferred from Electronic Annotation
more info
 
cell proliferation TAS
Traceable Author Statement
more info
PubMed 
nucleotide-excision repair, preincision complex assembly TAS
Traceable Author Statement
more info
 
positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription, DNA-templated NAS
Non-traceable Author Statement
more info
PubMed 
protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein stabilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cyclin-dependent protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
PubMed 
snRNA transcription by RNA polymerase II TAS
Traceable Author Statement
more info
 
termination of RNA polymerase I transcription TAS
Traceable Author Statement
more info
 
transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
transcription by RNA polymerase II TAS
Traceable Author Statement
more info
 
transcription elongation from RNA polymerase II promoter TAS
Traceable Author Statement
more info
 
transcription initiation from RNA polymerase I promoter TAS
Traceable Author Statement
more info
 
transcription initiation from RNA polymerase II promoter TAS
Traceable Author Statement
more info
 
transcription-coupled nucleotide-excision repair TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cyclin-dependent protein kinase activating kinase holoenzyme complex IMP
Inferred from Mutant Phenotype
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
transcription factor TFIIH holo complex IDA
Inferred from Direct Assay
more info
PubMed 
transcription factor TFIIK complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
cyclin-dependent kinase 7
Names
39 KDa protein kinase
CDK-activating kinase 1
TFIIH basal transcription factor complex kinase subunit
cell division protein kinase 7
cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase)
homolog of Xenopus MO15 Cdk-activating kinase
kinase subunit of CAK
serine/threonine kinase stk1
serine/threonine protein kinase 1
serine/threonine protein kinase MO15
NP_001310998.1
NP_001310999.1
NP_001311000.1
NP_001311001.1
NP_001311003.1
NP_001311004.1
NP_001311006.1
NP_001311007.1
NP_001790.1
XP_011541396.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001324069.1NP_001310998.1  cyclin-dependent kinase 7 isoform 2

    Status: VALIDATED

    Source sequence(s)
    BC005298, BI520184, CA437275, L20320
    UniProtKB/Swiss-Prot
    P50613
    Conserved Domains (1) summary
    cd07841
    Location:2267
    STKc_CDK7; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 7
  2. NM_001324070.1NP_001310999.1  cyclin-dependent kinase 7 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC145132, AK308493, BC000834, CA437275
    UniProtKB/Swiss-Prot
    P50613
    Conserved Domains (2) summary
    PTZ00024
    Location:7251
    PTZ00024; cyclin-dependent protein kinase; Provisional
    cd07841
    Location:11251
    STKc_CDK7; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 7
  3. NM_001324071.1NP_001311000.1  cyclin-dependent kinase 7 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC145132, BC000834, BC005298, CA437275
    UniProtKB/Swiss-Prot
    P50613
    Conserved Domains (1) summary
    cl21453
    Location:43251
    PKc_like; Protein Kinases, catalytic domain
  4. NM_001324072.1NP_001311001.1  cyclin-dependent kinase 7 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC145132
    Consensus CDS
    CCDS83002.1
    UniProtKB/TrEMBL
    D6R9G1
    Conserved Domains (1) summary
    cd07841
    Location:1215
    STKc_CDK7; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 7
  5. NM_001324074.1NP_001311003.1  cyclin-dependent kinase 7 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC145132
    Consensus CDS
    CCDS83002.1
    UniProtKB/TrEMBL
    D6R9G1
    Conserved Domains (1) summary
    cd07841
    Location:1215
    STKc_CDK7; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 7
  6. NM_001324075.1NP_001311004.1  cyclin-dependent kinase 7 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC145132
    Consensus CDS
    CCDS83002.1
    UniProtKB/TrEMBL
    D6R9G1
    Conserved Domains (1) summary
    cd07841
    Location:1215
    STKc_CDK7; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 7
  7. NM_001324077.1NP_001311006.1  cyclin-dependent kinase 7 isoform 4

    Status: VALIDATED

    Source sequence(s)
    BC005298, BI520184, BU660651, CA305960, CA437275
    Consensus CDS
    CCDS83002.1
    UniProtKB/Swiss-Prot
    P50613
    UniProtKB/TrEMBL
    D6R9G1
    Related
    ENSP00000422121.1, ENST00000502604.5
    Conserved Domains (1) summary
    cd07841
    Location:1215
    STKc_CDK7; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 7
  8. NM_001324078.1NP_001311007.1  cyclin-dependent kinase 7 isoform 4

    Status: VALIDATED

    Source sequence(s)
    BI520184, CA437275, KU177971
    Consensus CDS
    CCDS83002.1
    UniProtKB/TrEMBL
    D6R9G1, D6RFL0
    Conserved Domains (1) summary
    cd07841
    Location:1215
    STKc_CDK7; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 7
  9. NM_001799.4NP_001790.1  cyclin-dependent kinase 7 isoform 1

    See identical proteins and their annotated locations for NP_001790.1

    Status: VALIDATED

    Source sequence(s)
    BC000834, BC005298, BI520184, CA437275
    Consensus CDS
    CCDS3999.1
    UniProtKB/Swiss-Prot
    P50613
    UniProtKB/TrEMBL
    A0A0S2Z3F9
    Related
    ENSP00000256443.3, ENST00000256443.7
    Conserved Domains (1) summary
    cd07841
    Location:11308
    STKc_CDK7; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 7

RNA

  1. NR_136690.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC145132
    Related
    ENST00000629350.2

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p12 Primary Assembly

    Range
    69234795..69277430
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011543094.2XP_011541396.1  cyclin-dependent kinase 7 isoform X1

    Conserved Domains (1) summary
    cl21453
    Location:1191
    PKc_like; Protein Kinases, catalytic domain

Reference GRCh38.p12 ALT_REF_LOCI_1

Genomic

  1. NW_003315917.2 Reference GRCh38.p12 ALT_REF_LOCI_1

    Range
    17975..60596
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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