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INO80C INO80 complex subunit C [ Homo sapiens (human) ]

Gene ID: 125476, updated on 26-Nov-2021

Summary

Official Symbol
INO80Cprovided by HGNC
Official Full Name
INO80 complex subunit Cprovided by HGNC
Primary source
HGNC:HGNC:26994
See related
Ensembl:ENSG00000153391
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IES6; hIes6; C18orf37
Expression
Broad expression in testis (RPKM 20.7), esophagus (RPKM 7.5) and 24 other tissues See more
Orthologs
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Genomic context

See INO80C in Genome Data Viewer
Location:
18q12.2
Exon count:
9
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 18 NC_000018.10 (35468333..35497960, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (33048297..33077924, complement)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372063 Neighboring gene GATA motif-containing MPRA enhancer 294 Neighboring gene Sharpr-MPRA regulatory region 729 Neighboring gene polypeptide N-acetylgalactosaminyltransferase 1 Neighboring gene microRNA 3975 Neighboring gene uncharacterized LOC105372065

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ38183

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in DNA recombination IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
 
involved_in chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in chromatin remodeling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in nucleosome mobilization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of DNA replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of DNA strand elongation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of chromosome organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of Ino80 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of Ino80 complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of MLL1 complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
INO80 complex subunit C
Names
IES6 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001098817.2NP_001092287.1  INO80 complex subunit C isoform 1

    See identical proteins and their annotated locations for NP_001092287.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BF475320, BM758571, BQ887287, BY800049
    Consensus CDS
    CCDS45853.1
    UniProtKB/Swiss-Prot
    Q6PI98
    Related
    ENSP00000391457.1, ENST00000441607.6
    Conserved Domains (1) summary
    cl02154
    Location:103223
    YL1_C; YL1 nuclear protein C-terminal domain
  2. NM_001308064.2NP_001294993.1  INO80 complex subunit C isoform 3

    See identical proteins and their annotated locations for NP_001294993.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' structure, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to isoform 1. The resulting protein (isoform 3) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    BF475320, BQ441485
    Consensus CDS
    CCDS77177.1
    UniProtKB/TrEMBL
    K7EIY8
    Related
    ENSP00000464948.1, ENST00000586489.5
    Conserved Domains (1) summary
    cl02154
    Location:12132
    YL1_C; YL1 nuclear protein C-terminal domain
  3. NM_194281.4NP_919257.2  INO80 complex subunit C isoform 2

    See identical proteins and their annotated locations for NP_919257.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two alternate in-frame exons in the 5' coding region, compared to variant 1. The resulting protein (isoform 2) is shorter than isoform 1.
    Source sequence(s)
    BF475320, BQ887287
    Consensus CDS
    CCDS11914.1
    UniProtKB/Swiss-Prot
    Q6PI98
    Related
    ENSP00000334473.6, ENST00000334598.12
    Conserved Domains (1) summary
    cl02154
    Location:67187
    YL1_C; YL1 nuclear protein C-terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p13 Primary Assembly

    Range
    35468333..35497960 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011525812.3XP_011524114.1  INO80 complex subunit C isoform X1

    Conserved Domains (1) summary
    cl02154
    Location:41161
    YL1_C; YL1 nuclear protein C-terminal domain
  2. XM_005258197.5XP_005258254.1  INO80 complex subunit C isoform X2

    See identical proteins and their annotated locations for XP_005258254.1

    UniProtKB/TrEMBL
    K7EIY8
    Conserved Domains (1) summary
    cl02154
    Location:12132
    YL1_C; YL1 nuclear protein C-terminal domain
  3. XM_005258196.5XP_005258253.1  INO80 complex subunit C isoform X2

    See identical proteins and their annotated locations for XP_005258253.1

    UniProtKB/TrEMBL
    K7EIY8
    Conserved Domains (1) summary
    cl02154
    Location:12132
    YL1_C; YL1 nuclear protein C-terminal domain
  4. XM_024451089.1XP_024306857.1  INO80 complex subunit C isoform X2

    Conserved Domains (1) summary
    cl02154
    Location:12132
    YL1_C; YL1 nuclear protein C-terminal domain
  5. XM_017025549.1XP_016881038.1  INO80 complex subunit C isoform X2

    UniProtKB/TrEMBL
    K7EIY8
    Conserved Domains (1) summary
    cl02154
    Location:12132
    YL1_C; YL1 nuclear protein C-terminal domain
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