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RSKR ribosomal protein S6 kinase related [ Homo sapiens (human) ]

Gene ID: 124923, updated on 6-Jul-2026
Official Symbol
RSKRprovided by HGNC
Official Full Name
ribosomal protein S6 kinase relatedprovided by HGNC
Primary source
HGNC:HGNC:26314
See related
Ensembl:ENSG00000167524 AllianceGenome:HGNC:26314
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SGK494
Summary
Predicted to enable protein kinase activity. Predicted to be involved in chromatin remodeling. [provided by Alliance of Genome Resources, Apr 2025]
Expression
Broad expression in testis (RPKM 3.9), brain (RPKM 1.9) and 23 other tissues See more
Orthologs
all
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Try the new Transcripts and proteins table
See RSKR in Genome Data Viewer
Location:
17q11.2
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (28607963..28614185, complement)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (29550686..29556909, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (26934981..26941203, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8344 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11933 Neighboring gene aldolase, fructose-bisphosphate C Neighboring gene sperm associated antigen 5 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:26925705-26926249 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11934 Neighboring gene SPAG5 antisense RNA 1 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr17:26938368-26939567 Neighboring gene bridge-like lipid transfer protein family member 2 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:26954912-26955086 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8346 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8347 Neighboring gene stromal cell derived factor 2 Neighboring gene ribosomal protein S12 pseudogene 28

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. AGC protein kinases: from structural mechanism of regulation to allosteric drug development for the treatment of human diseases. Arencibia JM, et al. Biochim Biophys Acta, 2013 Jul. PMID 23524293
  2. The protein kinase complement of the human genome. Manning G, et al. Science, 2002 Dec 6. PMID 12471243
  3. RNF208, an estrogen-inducible E3 ligase, targets soluble Vimentin to suppress metastasis in triple-negative breast cancers. Pang K, et al. Nat Commun, 2019 Dec 20. PMID 31862882, Free PMC Article
  4. Ephrin-As, Eph receptors and integrin α3 interact and colocalise at membrane protrusions of U251MG glioblastoma cells. Makarov A, et al. Cell Biol Int, 2013 Oct. PMID 23686814
  5. N(6)-Methyladenosine on mRNA facilitates a phase-separated nuclear body that suppresses myeloid leukemic differentiation. Cheng Y, et al. Cancer Cell, 2021 Jul 12. PMID 34048709, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Potential readthrough

Included gene: SPAG5

Homology

Clone Names

  • FLJ25006, FLJ78978, MGC39533

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
ribosomal protein S6 kinase-related protein
Names
sugen kinase 494
NP_001167574.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001174103.2 → NP_001167574.1  ribosomal protein S6 kinase-related protein

    Status: VALIDATED

    Source sequence(s)
    AC005726
    UniProtKB/Swiss-Prot
    A0A5H1ZRP1, B4DFP4, L7N484, Q49A48, Q96LW2
    UniProtKB/TrEMBL
    A0ACI8RGU6
    Related
    ENSP00000301037.5, ENST00000301037.11
    Conserved Domains (2) summary
    smart00220
    Location:108 → 324
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05123
    Location:115 → 359
    STKc_AGC; Catalytic domain of AGC family Serine/Threonine Kinases

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    28607963..28614185 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    29550686..29556909 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_144610.1: Suppressed sequence

    Description
    NM_144610.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96LW2.3 GenPept UniProtKB/Swiss-Prot:Q96LW2

Gene LinkOut

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