Format

Send to:

Choose Destination

SPAG5 sperm associated antigen 5 [ Homo sapiens (human) ]

Gene ID: 10615, updated on 15-Jun-2019

Summary

Official Symbol
SPAG5provided by HGNC
Official Full Name
sperm associated antigen 5provided by HGNC
Primary source
HGNC:HGNC:13452
See related
Ensembl:ENSG00000076382 MIM:615562
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MAP126; DEEPEST; hMAP126
Summary
This gene encodes a protein associated with the mitotic spindle apparatus. The encoded protein may be involved in the functional and dynamic regulation of mitotic spindles. [provided by RefSeq, Jul 2008]
Expression
Biased expression in testis (RPKM 49.5), bone marrow (RPKM 14.3) and 9 other tissues See more
Orthologs

Genomic context

See SPAG5 in Genome Data Viewer
Location:
17q11.2
Exon count:
24
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 17 NC_000017.11 (28577565..28599038, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (26904583..26926056, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol glycan anchor biosynthesis class S Neighboring gene aldolase, fructose-bisphosphate C Neighboring gene SPAG5 antisense RNA 1 Neighboring gene ribosomal protein S6 kinase related Neighboring gene KIAA0100

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope transmembrane glycoprotein gp41 env HIV-1 gp41 is identified to have a physical interaction with sperm associated antigen 5 (SPAG5) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: RSKR

Homology

Clone Names

  • FLJ78978

Gene Ontology Provided by GOA

Function Evidence Code Pubs
microtubule binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell division IEA
Inferred from Electronic Annotation
more info
 
chromosome segregation IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitotic sister chromatid segregation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of intracellular transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of spindle assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein localization to centrosome IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of attachment of spindle microtubules to kinetochore IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of metaphase plate congression IMP
Inferred from Mutant Phenotype
more info
PubMed 
spindle organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
centriolar satellite IMP
Inferred from Mutant Phenotype
more info
PubMed 
condensed chromosome kinetochore IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
kinetochore IDA
Inferred from Direct Assay
more info
PubMed 
microtubule plus-end IDA
Inferred from Direct Assay
more info
PubMed 
midbody IEA
Inferred from Electronic Annotation
more info
 
mitotic spindle IDA
Inferred from Direct Assay
more info
PubMed 
mitotic spindle pole IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
sperm-associated antigen 5
Names
astrin
mitotic spindle associated protein p126
mitotic spindle coiled-coil related protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006461.4NP_006452.3  sperm-associated antigen 5

    See identical proteins and their annotated locations for NP_006452.3

    Status: REVIEWED

    Source sequence(s)
    BC000322, BI459711, BQ773438
    Consensus CDS
    CCDS32594.1
    UniProtKB/Swiss-Prot
    Q96R06
    Related
    ENSP00000323300.5, ENST00000321765.10
    Conserved Domains (2) summary
    COG1196
    Location:5941163
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam04598
    Location:742944
    Gasdermin; Gasdermin family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    28577574..28599025 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center