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CANT1 calcium activated nucleotidase 1 [ Homo sapiens (human) ]

Gene ID: 124583, updated on 7-Dec-2018

Summary

Official Symbol
CANT1provided by HGNC
Official Full Name
calcium activated nucleotidase 1provided by HGNC
Primary source
HGNC:HGNC:19721
See related
Ensembl:ENSG00000171302 MIM:613165
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DBQD; EDM7; DBQD1; SCAN1; SHAPY; SCAN-1
Summary
This protein encoded by this gene belongs to the apyrase family. It functions as a calcium-dependent nucleotidase with a preference for UDP. Mutations in this gene are associated with Desbuquois dysplasia with hand anomalies. Alternatively spliced transcript variants have been noted for this gene.[provided by RefSeq, Mar 2010]
Expression
Broad expression in colon (RPKM 44.8), prostate (RPKM 33.6) and 24 other tissues See more
Orthologs

Genomic context

See CANT1 in Genome Data Viewer
Location:
17q25.3
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 17 NC_000017.11 (78991716..79009817, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (76987798..77005899, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene TIMP metallopeptidase inhibitor 2 Neighboring gene CEP295 N-terminal like Neighboring gene galectin 3 binding protein Neighboring gene C1QTNF1 antisense RNA 1 Neighboring gene C1q and TNF related 1 Neighboring gene endo-beta-N-acetylglucosaminidase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of calcium activated nucleotidase 1 (CANT1) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
adenosine-diphosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
calcium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
guanosine-diphosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
guanosine-diphosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
uridine-diphosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
neutrophil degranulation TAS
Traceable Author Statement
more info
 
positive regulation of I-kappaB kinase/NF-kappaB signaling HMP PubMed 
proteoglycan biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
proteoglycan biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
Golgi cisterna membrane IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome HDA PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
ficolin-1-rich granule lumen TAS
Traceable Author Statement
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
specific granule lumen TAS
Traceable Author Statement
more info
 
tertiary granule lumen TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
soluble calcium-activated nucleotidase 1
Names
Ca2+-dependent endoplasmic reticulum nucleoside diphosphatase
apyrase homolog
micromelic dwarfism with vertebral and metaphyseal abnormalities and advanced carpotarsal ossification
putative MAPK-activating protein PM09
putative NF-kappa-B-activating protein 107
soluble Ca-activated nucleotidase, isozyme 1
soluble calcium-activated nucleotidase SCAN-1
NP_001153244.1
NP_001153245.1
NP_620148.1
XP_005257078.1
XP_005257079.1
XP_006721746.1
XP_011522593.1
XP_011522595.1
XP_011522596.1
XP_011522597.1
XP_024306332.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016645.1 RefSeqGene

    Range
    5001..23102
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001159772.1NP_001153244.1  soluble calcium-activated nucleotidase 1

    See identical proteins and their annotated locations for NP_001153244.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AF328554, BC017655, DC355691
    Consensus CDS
    CCDS11760.1
    UniProtKB/Swiss-Prot
    Q8WVQ1
    UniProtKB/TrEMBL
    A0A024R8U8
    Related
    ENSP00000467437.1, ENST00000591773.5
    Conserved Domains (1) summary
    pfam06079
    Location:113400
    Apyrase; Apyrase
  2. NM_001159773.2NP_001153245.1  soluble calcium-activated nucleotidase 1

    See identical proteins and their annotated locations for NP_001153245.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    BC017655, DC355691
    Consensus CDS
    CCDS11760.1
    UniProtKB/Swiss-Prot
    Q8WVQ1
    UniProtKB/TrEMBL
    A0A024R8U8
    Related
    ENSP00000376241.4, ENST00000392446.9
    Conserved Domains (1) summary
    pfam06079
    Location:113400
    Apyrase; Apyrase
  3. NM_138793.3NP_620148.1  soluble calcium-activated nucleotidase 1

    See identical proteins and their annotated locations for NP_620148.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AK074687, BC017655, DC355691
    Consensus CDS
    CCDS11760.1
    UniProtKB/Swiss-Prot
    Q8WVQ1
    UniProtKB/TrEMBL
    A0A024R8U8
    Related
    ENSP00000307674.2, ENST00000302345.6
    Conserved Domains (1) summary
    pfam06079
    Location:113400
    Apyrase; Apyrase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p12 Primary Assembly

    Range
    78991716..79009817 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006721683.1XP_006721746.1  soluble calcium-activated nucleotidase 1 isoform X1

    See identical proteins and their annotated locations for XP_006721746.1

    UniProtKB/Swiss-Prot
    Q8WVQ1
    UniProtKB/TrEMBL
    A0A024R8U8
    Conserved Domains (1) summary
    pfam06079
    Location:113400
    Apyrase; Apyrase
  2. XM_011524293.1XP_011522595.1  soluble calcium-activated nucleotidase 1 isoform X1

    See identical proteins and their annotated locations for XP_011522595.1

    UniProtKB/Swiss-Prot
    Q8WVQ1
    UniProtKB/TrEMBL
    A0A024R8U8
    Conserved Domains (1) summary
    pfam06079
    Location:113400
    Apyrase; Apyrase
  3. XM_011524291.1XP_011522593.1  soluble calcium-activated nucleotidase 1 isoform X1

    See identical proteins and their annotated locations for XP_011522593.1

    UniProtKB/Swiss-Prot
    Q8WVQ1
    UniProtKB/TrEMBL
    A0A024R8U8
    Conserved Domains (1) summary
    pfam06079
    Location:113400
    Apyrase; Apyrase
  4. XM_024450564.1XP_024306332.1  soluble calcium-activated nucleotidase 1 isoform X1

    Conserved Domains (1) summary
    pfam06079
    Location:113400
    Apyrase; Apyrase
  5. XM_011524295.2XP_011522597.1  soluble calcium-activated nucleotidase 1 isoform X1

    See identical proteins and their annotated locations for XP_011522597.1

    UniProtKB/Swiss-Prot
    Q8WVQ1
    UniProtKB/TrEMBL
    A0A024R8U8
    Conserved Domains (1) summary
    pfam06079
    Location:113400
    Apyrase; Apyrase
  6. XM_005257022.1XP_005257079.1  soluble calcium-activated nucleotidase 1 isoform X1

    See identical proteins and their annotated locations for XP_005257079.1

    UniProtKB/Swiss-Prot
    Q8WVQ1
    UniProtKB/TrEMBL
    A0A024R8U8
    Conserved Domains (1) summary
    pfam06079
    Location:113400
    Apyrase; Apyrase
  7. XM_011524294.2XP_011522596.1  soluble calcium-activated nucleotidase 1 isoform X1

    See identical proteins and their annotated locations for XP_011522596.1

    UniProtKB/Swiss-Prot
    Q8WVQ1
    UniProtKB/TrEMBL
    A0A024R8U8
    Conserved Domains (1) summary
    pfam06079
    Location:113400
    Apyrase; Apyrase
  8. XM_005257021.1XP_005257078.1  soluble calcium-activated nucleotidase 1 isoform X1

    See identical proteins and their annotated locations for XP_005257078.1

    UniProtKB/Swiss-Prot
    Q8WVQ1
    UniProtKB/TrEMBL
    A0A024R8U8
    Conserved Domains (1) summary
    pfam06079
    Location:113400
    Apyrase; Apyrase

RNA

  1. XR_001752424.2 RNA Sequence

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