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Cant1 calcium activated nucleotidase 1 [ Mus musculus (house mouse) ]

Gene ID: 76025, updated on 3-Oct-2020

Summary

Official Symbol
Cant1provided by MGI
Official Full Name
calcium activated nucleotidase 1provided by MGI
Primary source
MGI:MGI:1923275
See related
Ensembl:ENSMUSG00000025575
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sh; Apy; SCA; Apy1h; Shapy; Entpd8; SCAN-1; D11Bwg0554e; 5830420C20Rik
Summary
The protein encoded by this gene is a calcium-dependent nucleotidase that preferentially hydrolyzes UDP, GDP, and IDP. The encoded protein has low activity with ADP and ATP and shows no activity with AMP and GMP. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2012]
Expression
Ubiquitous expression in colon adult (RPKM 53.2), duodenum adult (RPKM 33.4) and 28 other tissues See more
Orthologs

Genomic context

See Cant1 in Genome Data Viewer
Location:
11 E2; 11 83.15 cM
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (118297115..118309971, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (118406289..118419134, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (118267603..118280366, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene tissue inhibitor of metalloproteinase 2 Neighboring gene CEP295 N-terminal like Neighboring gene lectin, galactoside-binding, soluble, 3 binding protein Neighboring gene predicted gene, 35598 Neighboring gene C1q and tumor necrosis factor related protein 1 Neighboring gene predicted gene 11747

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
adenosine-diphosphatase activity ISO
Inferred from Sequence Orthology
more info
 
calcium ion binding ISO
Inferred from Sequence Orthology
more info
 
guanosine-diphosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
guanosine-diphosphatase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nucleoside-diphosphatase activity IEA
Inferred from Electronic Annotation
more info
 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
uridine-diphosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
uridine-diphosphatase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
Process Evidence Code Pubs
proteoglycan biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
proteoglycan biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
ribonucleoside diphosphate catabolic process IC
Inferred by Curator
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
PubMed 
endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
soluble calcium-activated nucleotidase 1
Names
Ca2+-dependent endoplasmic reticulum nucleoside diphosphatase
apyrase 1, homolog (C. lectularius)
apyrase homolog
NP_001020788.1
NP_001020789.1
NP_001254520.1
NP_001254521.1
NP_083778.2
XP_006534467.1
XP_006534468.1
XP_006534469.1
XP_006534470.1
XP_006534471.1
XP_006534472.1
XP_006534473.1
XP_030102267.1
XP_030102268.1
XP_030102269.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025617.2NP_001020788.1  soluble calcium-activated nucleotidase 1 isoform a

    See identical proteins and their annotated locations for NP_001020788.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, and 4 all encode the same isoform (a).
    Source sequence(s)
    AK081118, AL591075, AL591404, BF465199, CD562087
    Consensus CDS
    CCDS25702.1
    UniProtKB/Swiss-Prot
    Q8VCF1
    Related
    ENSMUSP00000101895.1, ENSMUST00000106288.7
    Conserved Domains (1) summary
    pfam06079
    Location:115402
    Apyrase
  2. NM_001025618.2NP_001020789.1  soluble calcium-activated nucleotidase 1 isoform a

    See identical proteins and their annotated locations for NP_001020789.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, and 4 all encode the same isoform (a).
    Source sequence(s)
    AK049879, AL591075, AL591404, BF465199
    Consensus CDS
    CCDS25702.1
    UniProtKB/Swiss-Prot
    Q8VCF1
    Related
    ENSMUSP00000101894.1, ENSMUST00000106287.7
    Conserved Domains (1) summary
    pfam06079
    Location:115402
    Apyrase
  3. NM_001267591.1NP_001254520.1  soluble calcium-activated nucleotidase 1 isoform a

    See identical proteins and their annotated locations for NP_001254520.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, and 4 all encode the same isoform (a).
    Source sequence(s)
    AK049879, AL591404, BF465199
    Consensus CDS
    CCDS25702.1
    UniProtKB/Swiss-Prot
    Q8VCF1
    Related
    ENSMUSP00000126919.1, ENSMUST00000164927.1
    Conserved Domains (1) summary
    pfam06079
    Location:115402
    Apyrase
  4. NM_001267592.1NP_001254521.1  soluble calcium-activated nucleotidase 1 isoform b

    See identical proteins and their annotated locations for NP_001254521.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and contains an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is longer compared to isoform a.
    Source sequence(s)
    AK006565, AL591075, AL591404, BF465199
    Consensus CDS
    CCDS59572.1
    UniProtKB/Swiss-Prot
    Q8VCF1
    Related
    ENSMUSP00000101896.2, ENSMUST00000106289.8
    Conserved Domains (1) summary
    pfam06079
    Location:115439
    Apyrase
  5. NM_029502.3NP_083778.2  soluble calcium-activated nucleotidase 1 isoform a

    See identical proteins and their annotated locations for NP_083778.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform a. Variants 1, 2, 3, and 4 all encode the same isoform (a).
    Source sequence(s)
    AK049879, AK081118, AL591075, AL591404, BF465199
    Consensus CDS
    CCDS25702.1
    UniProtKB/Swiss-Prot
    Q8VCF1
    Related
    ENSMUSP00000090032.3, ENSMUST00000092378.9
    Conserved Domains (1) summary
    pfam06079
    Location:115402
    Apyrase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    118297115..118309971 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006534409.2XP_006534472.1  soluble calcium-activated nucleotidase 1 isoform X1

    See identical proteins and their annotated locations for XP_006534472.1

    UniProtKB/Swiss-Prot
    Q8VCF1
    Conserved Domains (1) summary
    pfam06079
    Location:115439
    Apyrase
  2. XM_030246409.2XP_030102269.1  soluble calcium-activated nucleotidase 1 isoform X2

    Conserved Domains (1) summary
    pfam06079
    Location:115402
    Apyrase
  3. XM_006534407.4XP_006534470.1  soluble calcium-activated nucleotidase 1 isoform X1

    See identical proteins and their annotated locations for XP_006534470.1

    UniProtKB/Swiss-Prot
    Q8VCF1
    Conserved Domains (1) summary
    pfam06079
    Location:115439
    Apyrase
  4. XM_030246408.2XP_030102268.1  soluble calcium-activated nucleotidase 1 isoform X2

    Conserved Domains (1) summary
    pfam06079
    Location:115402
    Apyrase
  5. XM_006534406.4XP_006534469.1  soluble calcium-activated nucleotidase 1 isoform X1

    See identical proteins and their annotated locations for XP_006534469.1

    UniProtKB/Swiss-Prot
    Q8VCF1
    Conserved Domains (1) summary
    pfam06079
    Location:115439
    Apyrase
  6. XM_030246407.2XP_030102267.1  soluble calcium-activated nucleotidase 1 isoform X2

    Conserved Domains (1) summary
    pfam06079
    Location:115402
    Apyrase
  7. XM_006534405.4XP_006534468.1  soluble calcium-activated nucleotidase 1 isoform X1

    See identical proteins and their annotated locations for XP_006534468.1

    UniProtKB/Swiss-Prot
    Q8VCF1
    Conserved Domains (1) summary
    pfam06079
    Location:115439
    Apyrase
  8. XM_006534404.4XP_006534467.1  soluble calcium-activated nucleotidase 1 isoform X1

    See identical proteins and their annotated locations for XP_006534467.1

    UniProtKB/Swiss-Prot
    Q8VCF1
    Conserved Domains (1) summary
    pfam06079
    Location:115439
    Apyrase
  9. XM_006534410.5XP_006534473.1  soluble calcium-activated nucleotidase 1 isoform X1

    See identical proteins and their annotated locations for XP_006534473.1

    UniProtKB/Swiss-Prot
    Q8VCF1
    Conserved Domains (1) summary
    pfam06079
    Location:115439
    Apyrase
  10. XM_006534408.5XP_006534471.1  soluble calcium-activated nucleotidase 1 isoform X1

    See identical proteins and their annotated locations for XP_006534471.1

    UniProtKB/Swiss-Prot
    Q8VCF1
    Conserved Domains (1) summary
    pfam06079
    Location:115439
    Apyrase
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