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CMKLR1 chemerin chemokine-like receptor 1 [ Homo sapiens (human) ]

Gene ID: 1240, updated on 12-Oct-2019

Summary

Official Symbol
CMKLR1provided by HGNC
Official Full Name
chemerin chemokine-like receptor 1provided by HGNC
Primary source
HGNC:HGNC:2121
See related
Ensembl:ENSG00000174600 MIM:602351
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DEZ; RVER1; ChemR23; CHEMERINR
Expression
Broad expression in spleen (RPKM 14.3), placenta (RPKM 10.1) and 22 other tissues See more
Orthologs

Genomic context

See CMKLR1 in Genome Data Viewer
Location:
12q23.3
Exon count:
5
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (108288044..108339347, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (108681821..108733094, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene WSC domain containing 2 Neighboring gene uncharacterized LOC105369965 Neighboring gene DNA dC->dU-editing enzyme APOBEC-3G-like Neighboring gene Sharpr-MPRA regulatory region 8395 Neighboring gene long intergenic non-protein coding RNA 1498 Neighboring gene FIC domain containing

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
NHGRI GWA Catalog
Genome-wide association study in a Swedish population yields support for greater CNV and MHC involvement in schizophrenia compared with bipolar disorder.
NHGRI GWA Catalog
Genome-wide association study of survival in non-small cell lung cancer patients receiving platinum-based chemotherapy.
NHGRI GWA Catalog
Genome-wide association study to identify single nucleotide polymorphisms (SNPs) associated with the development of erectile dysfunction in African-American men after radiotherapy for prostate cancer.
NHGRI GWA Catalog
Genome-wide data reveal novel genes for methotrexate response in a large cohort of juvenile idiopathic arthritis cases.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of chemokine-like receptor 1 (CMKLR1) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 isolates showing CCR3 tropism are particularly efficient in using CMKLR1/ChemR23 as a co-receptor; some HIV-2 and SIV isolates also use CMKLR1/ChemR23 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • GPCRs, Class A Rhodopsin-like, organism-specific biosystem (from WikiPathways)
    GPCRs, Class A Rhodopsin-like, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.gpcr.org/7tm/ (originally at http://www.cmbi.kun.nl/7tm/). The groupings are based on the GPCR phylogenetic tree available fr...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC126105, MGC126106

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G protein-coupled receptor activity NAS
Non-traceable Author Statement
more info
PubMed 
chemokine receptor activity TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
signaling receptor activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
G protein-coupled receptor signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
chemokine-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
complement receptor mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
immune response TAS
Traceable Author Statement
more info
PubMed 
inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of NF-kappaB transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of interleukin-12 production ISS
Inferred from Sequence or Structural Similarity
more info
 
phospholipase C-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of fat cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of macrophage chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of macrophage chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of calcium-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of calcium-mediated signaling IDA
Inferred from Direct Assay
more info
PubMed 
skeletal system development TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cell IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane NAS
Non-traceable Author Statement
more info
PubMed 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
chemokine-like receptor 1
Names
G-protein coupled receptor ChemR23
G-protein coupled receptor DEZ
chemerin receptor
chemokine receptor-like 1
orphan G-protein coupled receptor, Dez
resolvin E1 receptor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001142343.2NP_001135815.1  chemokine-like receptor 1 isoform a

    See identical proteins and their annotated locations for NP_001135815.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
    Source sequence(s)
    AC009729, AC063957, BC106927, DA466082
    Consensus CDS
    CCDS44965.1
    UniProtKB/Swiss-Prot
    Q99788
    Related
    ENSP00000449716.1, ENST00000550402.6
    Conserved Domains (1) summary
    cd15116
    Location:41327
    7tmA_CMKLR1; chemokine-like receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. NM_001142344.2NP_001135816.1  chemokine-like receptor 1 isoform a

    See identical proteins and their annotated locations for NP_001135816.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. It encodes isoform a.
    Source sequence(s)
    AC009729, AC063957, AK291800
    Consensus CDS
    CCDS44965.1
    UniProtKB/Swiss-Prot
    Q99788
    Related
    ENSP00000311733.7, ENST00000312143.11
    Conserved Domains (1) summary
    cd15116
    Location:41327
    7tmA_CMKLR1; chemokine-like receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors
  3. NM_001142345.1NP_001135817.1  chemokine-like receptor 1 isoform a

    See identical proteins and their annotated locations for NP_001135817.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. It encodes isoform a.
    Source sequence(s)
    AC009729, AC063957, BP328503, DA939526
    Consensus CDS
    CCDS44965.1
    UniProtKB/Swiss-Prot
    Q99788
    Related
    ENSP00000401293.1, ENST00000412676.5
    Conserved Domains (1) summary
    cd15116
    Location:41327
    7tmA_CMKLR1; chemokine-like receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors
  4. NM_004072.3NP_004063.1  chemokine-like receptor 1 isoform b

    See identical proteins and their annotated locations for NP_004063.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding sequence, compared to variant 1. It encodes isoform b, which has a shorter N-terminus than isoform a.
    Source sequence(s)
    AC009729, DA466082, U79527
    Consensus CDS
    CCDS41829.1
    UniProtKB/Swiss-Prot
    Q99788
    Related
    ENSP00000447579.1, ENST00000552995.5
    Conserved Domains (1) summary
    pfam00001
    Location:55314
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    108288044..108339347 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017018820.2XP_016874309.1  chemokine-like receptor 1 isoform X1

    UniProtKB/Swiss-Prot
    Q99788
    Conserved Domains (1) summary
    pfam00001
    Location:55314
    7tm_1; 7 transmembrane receptor (rhodopsin family)
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