U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Cmklr1 chemerin chemokine-like receptor 1 [ Mus musculus (house mouse) ]

Gene ID: 14747, updated on 22-Jan-2023

Summary

Official Symbol
Cmklr1provided by MGI
Official Full Name
chemerin chemokine-like receptor 1provided by MGI
Primary source
MGI:MGI:109603
See related
Ensembl:ENSMUSG00000042190 AllianceGenome:MGI:109603
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DEZ; Gpcr27; ChemR23; mcmklr1
Summary
Predicted to enable adipokinetic hormone binding activity; adipokinetic hormone receptor activity; and transmembrane signaling receptor activity. Involved in negative regulation of interleukin-12 production; positive regulation of cold-induced thermogenesis; and positive regulation of fat cell differentiation. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; lung; and uterus. Orthologous to human CMKLR1 (chemerin chemokine-like receptor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in lung adult (RPKM 58.5), subcutaneous fat pad adult (RPKM 38.4) and 12 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Cmklr1 in Genome Data Viewer
Location:
5; 5 F
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (113750415..113792971, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (113612355..113650475, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30812 Neighboring gene WSC domain containing 2 Neighboring gene predicted gene, 52822 Neighboring gene predicted gene 15736 Neighboring gene predicted gene, 52823 Neighboring gene RIKEN cDNA 1700069L16 gene Neighboring gene predicted gene, 46919 Neighboring gene FIC domain containing

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables adipokinetic hormone binding ISO
Inferred from Sequence Orthology
more info
 
enables adipokinetic hormone receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables complement receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in complement receptor mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of interleukin-12 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of cold-induced thermogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of macrophage chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of macrophage chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of calcium-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of calcium-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
chemerin-like receptor 1; chemokine-like receptor 1
Names
G-protein coupled receptor 27
G-protein coupled receptor DEZ
chemerin receptor
chemokine receptor-like 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359060.1NP_001345989.1  chemerin-like receptor 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AC241893, CJ072893
    Consensus CDS
    CCDS19551.1
    UniProtKB/Swiss-Prot
    P97468
    UniProtKB/TrEMBL
    Q497D3
    Conserved Domains (1) summary
    cd15116
    Location:39325
    7tmA_CMKLR1; chemokine-like receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. NM_008153.3NP_032179.1  chemerin-like receptor 1

    See identical proteins and their annotated locations for NP_032179.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AC241893, BY347978
    Consensus CDS
    CCDS19551.1
    UniProtKB/Swiss-Prot
    P97468
    UniProtKB/TrEMBL
    Q497D3
    Related
    ENSMUSP00000036316.7, ENSMUST00000047936.13
    Conserved Domains (1) summary
    cd15116
    Location:39325
    7tmA_CMKLR1; chemokine-like receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    113750415..113792971 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036164795.1XP_036020688.1  chemokine-like receptor 1 isoform X1

    UniProtKB/Swiss-Prot
    P97468
    UniProtKB/TrEMBL
    Q497D3
    Conserved Domains (1) summary
    cd15116
    Location:39325
    7tmA_CMKLR1; chemokine-like receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. XM_006530164.5XP_006530227.1  chemokine-like receptor 1 isoform X1

    See identical proteins and their annotated locations for XP_006530227.1

    UniProtKB/Swiss-Prot
    P97468
    UniProtKB/TrEMBL
    Q497D3
    Conserved Domains (1) summary
    cd15116
    Location:39325
    7tmA_CMKLR1; chemokine-like receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors
  3. XM_006530166.3XP_006530229.1  chemokine-like receptor 1 isoform X1

    See identical proteins and their annotated locations for XP_006530229.1

    UniProtKB/Swiss-Prot
    P97468
    UniProtKB/TrEMBL
    Q497D3
    Related
    ENSMUSP00000121765.2, ENSMUST00000132065.8
    Conserved Domains (1) summary
    cd15116
    Location:39325
    7tmA_CMKLR1; chemokine-like receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors
  4. XM_006530165.4XP_006530228.1  chemokine-like receptor 1 isoform X1

    See identical proteins and their annotated locations for XP_006530228.1

    UniProtKB/Swiss-Prot
    P97468
    UniProtKB/TrEMBL
    Q497D3
    Conserved Domains (1) summary
    cd15116
    Location:39325
    7tmA_CMKLR1; chemokine-like receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors