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ZNF641 zinc finger protein 641 [ Homo sapiens (human) ]

Gene ID: 121274, updated on 7-Jun-2020

Summary

Official Symbol
ZNF641provided by HGNC
Official Full Name
zinc finger protein 641provided by HGNC
Primary source
HGNC:HGNC:31834
See related
Ensembl:ENSG00000167528 MIM:613906
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in adrenal (RPKM 5.5), ovary (RPKM 3.9) and 25 other tissues See more
Orthologs

Genomic context

See ZNF641 in Genome Data Viewer
Location:
12q13.11
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (48334380..48351414, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (48729065..48745029, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369753 Neighboring gene H1.7 linker histone Neighboring gene olfactory receptor family 5 subfamily BK member 1 pseudogene Neighboring gene olfactory receptor family 5 subfamily BT member 1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ31295, DKFZp667D1012

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001172681.2NP_001166152.1  zinc finger protein 641 isoform 2

    See identical proteins and their annotated locations for NP_001166152.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon and uses a downstream start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC024257, AY842285, BC018090
    Consensus CDS
    CCDS53788.1
    UniProtKB/Swiss-Prot
    Q96N77
    Related
    ENSP00000449974.1, ENST00000547026.5
    Conserved Domains (6) summary
    smart00349
    Location:95156
    KRAB; krueppel associated box
    COG5048
    Location:337416
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:252272
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:358380
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:95135
    KRAB; KRAB box
    pfam13465
    Location:264289
    zf-H2C2_2; Zinc-finger double domain
  2. NM_001172682.2NP_001166153.1  zinc finger protein 641 isoform 3

    See identical proteins and their annotated locations for NP_001166153.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents use of an alternate transcription start site and 5' UTR, uses a downstream start codon, and lacks an alternate in-frame exon in the central coding region, compared to variant 1. The resulting isoform (3) has a shorter N-terminus and lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    AC024257, AK298064, DB445168
    Consensus CDS
    CCDS53787.1
    UniProtKB/Swiss-Prot
    Q96N77
    Related
    ENSP00000394627.3, ENST00000448928.7
    Conserved Domains (4) summary
    COG5048
    Location:328407
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:243263
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:255280
    zf-H2C2_2; Zinc-finger double domain
    cl25431
    Location:290
    PurL1; Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain [Nucleotide transport and metabolism]
  3. NM_001365803.1NP_001352732.1  zinc finger protein 641 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC024257
    Conserved Domains (4) summary
    COG5048
    Location:328407
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:243263
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:255280
    zf-H2C2_2; Zinc-finger double domain
    cl25431
    Location:290
    PurL1; Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain [Nucleotide transport and metabolism]
  4. NM_001365804.1NP_001352733.1  zinc finger protein 641 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC024257
    Conserved Domains (2) summary
    smart00349
    Location:95156
    KRAB; krueppel associated box
    cl25431
    Location:290
    PurL1; Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain [Nucleotide transport and metabolism]
  5. NM_001365805.1NP_001352734.1  zinc finger protein 641 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC024257, DA115635
    Conserved Domains (3) summary
    COG5048
    Location:194273
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:109129
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:121146
    zf-H2C2_2; Zinc-finger double domain
  6. NM_152320.3NP_689533.2  zinc finger protein 641 isoform 1

    See identical proteins and their annotated locations for NP_689533.2

    Status: VALIDATED

    Source sequence(s)
    AC024257, AK055857
    Consensus CDS
    CCDS8763.1
    UniProtKB/Swiss-Prot
    Q96N77
    Related
    ENSP00000301042.3, ENST00000301042.7
    Conserved Domains (6) summary
    smart00349
    Location:109170
    KRAB; krueppel associated box
    COG5048
    Location:351430
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:266286
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:372394
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:109149
    KRAB; KRAB box
    pfam13465
    Location:278303
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    48334380..48351414 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005268640.5XP_005268697.1  zinc finger protein 641 isoform X7

    Conserved Domains (2) summary
    smart00349
    Location:109170
    KRAB; krueppel associated box
    pfam01352
    Location:109149
    KRAB; KRAB box
  2. XM_011537898.2XP_011536200.1  zinc finger protein 641 isoform X3

    See identical proteins and their annotated locations for XP_011536200.1

    UniProtKB/Swiss-Prot
    Q96N77
    Conserved Domains (6) summary
    smart00349
    Location:95156
    KRAB; krueppel associated box
    COG5048
    Location:337416
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:252272
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:358380
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:95135
    KRAB; KRAB box
    pfam13465
    Location:264289
    zf-H2C2_2; Zinc-finger double domain
  3. XM_017018798.2XP_016874287.1  zinc finger protein 641 isoform X5

  4. XM_005268638.4XP_005268695.1  zinc finger protein 641 isoform X3

    See identical proteins and their annotated locations for XP_005268695.1

    UniProtKB/Swiss-Prot
    Q96N77
    Conserved Domains (6) summary
    smart00349
    Location:95156
    KRAB; krueppel associated box
    COG5048
    Location:337416
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:252272
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:358380
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:95135
    KRAB; KRAB box
    pfam13465
    Location:264289
    zf-H2C2_2; Zinc-finger double domain
  5. XM_011537897.2XP_011536199.1  zinc finger protein 641 isoform X1

    See identical proteins and their annotated locations for XP_011536199.1

    UniProtKB/Swiss-Prot
    Q96N77
    Related
    ENSP00000437832.2, ENST00000544117.6
    Conserved Domains (6) summary
    smart00349
    Location:109170
    KRAB; krueppel associated box
    COG5048
    Location:351430
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:266286
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:372394
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:109149
    KRAB; KRAB box
    pfam13465
    Location:278303
    zf-H2C2_2; Zinc-finger double domain
  6. XM_005268637.3XP_005268694.1  zinc finger protein 641 isoform X2

    Conserved Domains (4) summary
    COG5048
    Location:342421
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:257277
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:363385
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:269294
    zf-H2C2_2; Zinc-finger double domain
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