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Axin1 axin 1 [ Mus musculus (house mouse) ]

Gene ID: 12005, updated on 10-Oct-2019

Summary

Official Symbol
Axin1provided by MGI
Official Full Name
axin 1provided by MGI
Primary source
MGI:MGI:1096327
See related
Ensembl:ENSMUSG00000024182
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fu; Kb; Ki; Axin; fused; kinky; knobbly; AI316800
Expression
Ubiquitous expression in thymus adult (RPKM 11.6), CNS E11.5 (RPKM 10.8) and 28 other tissues See more
Orthologs

Genomic context

See Axin1 in Genome Data Viewer
Location:
17 A3.3; 17 13.07 cM
Exon count:
13
Annotation release Status Assembly Chr Location
108 current GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (26131217..26195811)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (26275631..26332756)

Chromosome 17 - NC_000083.6Genomic Context describing neighboring genes Neighboring gene transmembrane protein 8 Neighboring gene mitochondrial ribosomal protein L28 Neighboring gene predicted gene, 46600 Neighboring gene protein disulfide isomerase associated 2 Neighboring gene Rho GDP dissociation inhibitor (GDI) gamma

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC132911

Gene Ontology Provided by MGI

Function Evidence Code Pubs
I-SMAD binding IDA
Inferred from Direct Assay
more info
PubMed 
I-SMAD binding IPI
Inferred from Physical Interaction
more info
PubMed 
I-SMAD binding ISO
Inferred from Sequence Orthology
more info
 
R-SMAD binding IPI
Inferred from Physical Interaction
more info
PubMed 
SMAD binding ISO
Inferred from Sequence Orthology
more info
 
armadillo repeat domain binding ISO
Inferred from Sequence Orthology
more info
 
beta-catenin binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
beta-catenin binding IPI
Inferred from Physical Interaction
more info
PubMed 
beta-catenin binding ISO
Inferred from Sequence Orthology
more info
 
enzyme binding ISO
Inferred from Sequence Orthology
more info
 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
molecular adaptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
 
p53 binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein C-terminus binding IDA
Inferred from Direct Assay
more info
PubMed 
protein C-terminus binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
protein homodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
protein self-association IPI
Inferred from Physical Interaction
more info
PubMed 
receptor signaling complex scaffold activity IEA
Inferred from Electronic Annotation
more info
 
signaling adaptor activity ISO
Inferred from Sequence Orthology
more info
 
signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
Wnt signaling pathway IPI
Inferred from Physical Interaction
more info
PubMed 
activation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
adult walking behavior IMP
Inferred from Mutant Phenotype
more info
 
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
axial mesoderm development IMP
Inferred from Mutant Phenotype
more info
PubMed 
axial mesoderm formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
 
cytoplasmic microtubule organization IGI
Inferred from Genetic Interaction
more info
PubMed 
dorsal/ventral axis specification IDA
Inferred from Direct Assay
more info
PubMed 
dorsal/ventral axis specification ISO
Inferred from Sequence Orthology
more info
PubMed 
dorsal/ventral pattern formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
dorsal/ventral pattern formation ISO
Inferred from Sequence Orthology
more info
PubMed 
embryonic skeletal joint morphogenesis IMP
Inferred from Mutant Phenotype
more info
 
erythrocyte homeostasis IMP
Inferred from Mutant Phenotype
more info
 
genetic imprinting IMP
Inferred from Mutant Phenotype
more info
PubMed 
head development IMP
Inferred from Mutant Phenotype
more info
PubMed 
hemoglobin metabolic process IMP
Inferred from Mutant Phenotype
more info
 
in utero embryonic development IGI
Inferred from Genetic Interaction
more info
PubMed 
in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of fat cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of protein metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription elongation from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
nervous system process IMP
Inferred from Mutant Phenotype
more info
 
nucleocytoplasmic transport IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of JNK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of JUN kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of JUN kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of JUN kinase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of peptidyl-threonine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of proteasomal ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein ubiquitination IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of protein ubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transforming growth factor beta receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transforming growth factor beta receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of transforming growth factor beta receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of ubiquitin-protein transferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
 
post-anal tail morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
protein homooligomerization ISO
Inferred from Sequence Orthology
more info
 
protein polyubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
regulation of canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
regulation of protein phosphorylation IGI
Inferred from Genetic Interaction
more info
PubMed 
sensory perception of sound IMP
Inferred from Mutant Phenotype
more info
PubMed 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
colocalizes_with Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
Wnt signalosome IDA
Inferred from Direct Assay
more info
PubMed 
beta-catenin destruction complex IDA
Inferred from Direct Assay
more info
PubMed 
beta-catenin destruction complex ISO
Inferred from Sequence Orthology
more info
 
beta-catenin destruction complex TAS
Traceable Author Statement
more info
PubMed 
cell cortex IDA
Inferred from Direct Assay
more info
PubMed 
cell periphery ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
PubMed 
colocalizes_with cytoplasmic microtubule IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
 
lateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
plasma membrane NAS
Non-traceable Author Statement
more info
PubMed 
postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
axin-1
Names
axis inhibition protein 1
protein Fused

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159598.1NP_001153070.1  axin-1 isoform 1

    See identical proteins and their annotated locations for NP_001153070.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the shorter isoform (1).
    Source sequence(s)
    AC126438, AC140047
    Consensus CDS
    CCDS50042.1
    UniProtKB/TrEMBL
    Q14DJ8
    Related
    ENSMUSP00000132000.1, ENSMUST00000163421.7
    Conserved Domains (4) summary
    cd08707
    Location:94214
    RGS_Axin; Regulator of G protein signaling (RGS) domain found in the Axin protein
    cd11582
    Location:1685
    Axin_TNKS_binding; Tankyrase binding N-terminal segment of axin
    pfam00778
    Location:752827
    DIX; DIX domain
    pfam08833
    Location:468521
    Axin_b-cat_bind; Axin beta-catenin binding domain
  2. NM_009733.2NP_033863.2  axin-1 isoform 2

    See identical proteins and their annotated locations for NP_033863.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant contains an alternate in-frame exon in the 3' coding region compared to variant 1, resulting in a longer protein (isoform 2) compared to isoform 1.
    Source sequence(s)
    AA259709, AF009011, AW061082, BG803725, CJ060582
    Consensus CDS
    CCDS28547.2
    UniProtKB/Swiss-Prot
    O35625
    UniProtKB/TrEMBL
    E9QMJ8
    Related
    ENSMUSP00000073974.3, ENSMUST00000074370.9
    Conserved Domains (4) summary
    cd08707
    Location:94214
    RGS_Axin; Regulator of G protein signaling (RGS) domain found in the Axin protein
    cd11582
    Location:1685
    Axin_TNKS_binding; Tankyrase binding N-terminal segment of axin
    pfam00778
    Location:788863
    DIX; DIX domain
    pfam08833
    Location:468521
    Axin_b-cat_bind; Axin beta-catenin binding domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p6 C57BL/6J

Genomic

  1. NC_000083.6 Reference GRCm38.p6 C57BL/6J

    Range
    26131217..26195811
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006523515.4XP_006523578.1  axin-1 isoform X1

    See identical proteins and their annotated locations for XP_006523578.1

    UniProtKB/TrEMBL
    E9QMJ8
    Conserved Domains (4) summary
    cd08707
    Location:94214
    RGS_Axin; Regulator of G protein signaling (RGS) domain found in the Axin protein
    cd11582
    Location:1685
    Axin_TNKS_binding; Tankyrase binding N-terminal segment of axin
    pfam00778
    Location:788863
    DIX; DIX domain
    pfam08833
    Location:468521
    Axin_b-cat_bind; Axin beta-catenin binding domain
  2. XM_030249451.1XP_030105311.1  axin-1 isoform X2

  3. XM_030249452.1XP_030105312.1  axin-1 isoform X2

  4. XM_006523516.2XP_006523579.1  axin-1 isoform X3

    Conserved Domains (2) summary
    pfam00778
    Location:428503
    DIX; DIX domain
    pfam08833
    Location:108161
    Axin_b-cat_bind; Axin beta-catenin binding domain
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