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Axin1 axin 1 [ Mus musculus (house mouse) ]

Gene ID: 12005, updated on 26-Feb-2024

Summary

Official Symbol
Axin1provided by MGI
Official Full Name
axin 1provided by MGI
Primary source
MGI:MGI:1096327
See related
Ensembl:ENSMUSG00000024182 AllianceGenome:MGI:1096327
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fu; Kb; Ki; Axin; fused; kinky; knobbly
Summary
Enables several functions, including SMAD binding activity; beta-catenin binding activity; and enzyme binding activity. Involved in positive regulation of JNK cascade; positive regulation of protein modification process; and positive regulation of transcription, DNA-templated. Acts upstream of or within several processes, including chordate embryonic development; negative regulation of macromolecule metabolic process; and regulation of protein metabolic process. Located in several cellular components, including cell cortex; cytoplasmic vesicle; and microtubule cytoskeleton. Part of Wnt signalosome and beta-catenin destruction complex. Is expressed in several structures, including alimentary system; forebrain; genitourinary system; hemolymphoid system gland; and retina. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human AXIN1 (axin 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 11.6), CNS E11.5 (RPKM 10.8) and 28 other tissues See more
Orthologs
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Genomic context

See Axin1 in Genome Data Viewer
Location:
17 A3.3; 17 13.07 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (26350294..26414784)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (26131217..26195811)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene post-glycosylphosphatidylinositol attachment to proteins 6 Neighboring gene STARR-positive B cell enhancer ABC_E5580 Neighboring gene mitochondrial ribosomal protein L28 Neighboring gene STARR-positive B cell enhancer ABC_E7501 Neighboring gene protein disulfide isomerase associated 2 Neighboring gene Rho GDP dissociation inhibitor gamma

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC132911

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables I-SMAD binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables I-SMAD binding IDA
Inferred from Direct Assay
more info
PubMed 
enables I-SMAD binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables I-SMAD binding ISO
Inferred from Sequence Orthology
more info
 
enables R-SMAD binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables SMAD binding ISO
Inferred from Sequence Orthology
more info
 
enables armadillo repeat domain binding ISO
Inferred from Sequence Orthology
more info
 
enables beta-catenin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables beta-catenin binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables beta-catenin binding ISO
Inferred from Sequence Orthology
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables molecular adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
 
enables p53 binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
enables protein homodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein self-association IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin ligase-substrate adaptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables ubiquitin ligase-substrate adaptor activity ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within Wnt signaling pathway IPI
Inferred from Physical Interaction
more info
PubMed 
involved_in activation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within adult walking behavior IMP
Inferred from Mutant Phenotype
more info
 
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within axial mesoderm development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within axial mesoderm formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell development IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within cytoplasmic microtubule organization IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within dorsal/ventral axis specification IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within dorsal/ventral axis specification ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within dorsal/ventral pattern formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within dorsal/ventral pattern formation ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within embryonic skeletal joint morphogenesis IMP
Inferred from Mutant Phenotype
more info
 
acts_upstream_of_or_within epigenetic programming in the zygotic pronuclei IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within erythrocyte homeostasis IMP
Inferred from Mutant Phenotype
more info
 
acts_upstream_of_or_within head development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within hemoglobin metabolic process IMP
Inferred from Mutant Phenotype
more info
 
acts_upstream_of_or_within in utero embryonic development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of fat cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of protein metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of transcription elongation by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within nervous system process IMP
Inferred from Mutant Phenotype
more info
 
acts_upstream_of_or_within nucleocytoplasmic transport IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of JNK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of JNK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of JUN kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of JUN kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of JUN kinase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in positive regulation of peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of peptidyl-threonine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within positive regulation of proteasomal ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of protein ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of protein ubiquitination IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of protein ubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of transforming growth factor beta receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of transforming growth factor beta receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of transforming growth factor beta receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within post-anal tail morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process NAS
Non-traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within protein polyubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of protein phosphorylation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within sensory perception of sound IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
colocalizes_with Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
part_of Wnt signalosome IDA
Inferred from Direct Assay
more info
PubMed 
part_of beta-catenin destruction complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of beta-catenin destruction complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of beta-catenin destruction complex ISO
Inferred from Sequence Orthology
more info
 
part_of beta-catenin destruction complex NAS
Non-traceable Author Statement
more info
PubMed 
part_of beta-catenin destruction complex TAS
Traceable Author Statement
more info
PubMed 
located_in cell cortex IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell periphery ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in lateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane NAS
Non-traceable Author Statement
more info
PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in synapse ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
axin-1
Names
axis inhibition protein 1
protein Fused

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159598.2NP_001153070.2  axin-1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the shorter isoform (1).
    Source sequence(s)
    AC126438, AC140047
    Consensus CDS
    CCDS50042.1
    UniProtKB/TrEMBL
    Q14DJ8
    Related
    ENSMUSP00001091662.1, ENSMUST00020183805.1
    Conserved Domains (3) summary
    cd08707
    Location:89209
    RGS_Axin; Regulator of G protein signaling (RGS) domain found in the Axin protein
    smart00021
    Location:745827
    DAX; Domain present in Dishevelled and axin
    cd11582
    Location:1180
    Axin_TNKS_binding; Tankyrase binding N-terminal segment of axin
  2. NM_001394381.1NP_001381310.1  axin-1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC126438, AC140047
    UniProtKB/Swiss-Prot
    O35625
    UniProtKB/TrEMBL
    E9QMJ8
    Conserved Domains (4) summary
    cd08707
    Location:89209
    RGS_Axin; Regulator of G protein signaling (RGS) domain found in the Axin protein
    smart00021
    Location:781863
    DAX; Domain present in Dishevelled and axin
    cd11582
    Location:1180
    Axin_TNKS_binding; Tankyrase binding N-terminal segment of axin
    pfam08833
    Location:464495
    Axin_b-cat_bind; Axin beta-catenin binding domain
  3. NM_001394382.1NP_001381311.1  axin-1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC126438, AC140047
    UniProtKB/TrEMBL
    Q14DJ8
    Conserved Domains (3) summary
    cd08707
    Location:89209
    RGS_Axin; Regulator of G protein signaling (RGS) domain found in the Axin protein
    smart00021
    Location:745827
    DAX; Domain present in Dishevelled and axin
    cd11582
    Location:1180
    Axin_TNKS_binding; Tankyrase binding N-terminal segment of axin
  4. NM_001394389.1NP_001381318.1  axin-1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC126438, AC140047
    UniProtKB/TrEMBL
    Q14DJ8
    Conserved Domains (3) summary
    cd08707
    Location:89209
    RGS_Axin; Regulator of G protein signaling (RGS) domain found in the Axin protein
    smart00021
    Location:745827
    DAX; Domain present in Dishevelled and axin
    cd11582
    Location:1180
    Axin_TNKS_binding; Tankyrase binding N-terminal segment of axin
  5. NM_009733.3NP_033863.3  axin-1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate in-frame exon in the 3' coding region compared to variant 1, resulting in a longer protein (isoform 2) compared to isoform 1.
    Source sequence(s)
    AC126438, AC140047
    Consensus CDS
    CCDS28547.2
    UniProtKB/Swiss-Prot
    O35625
    UniProtKB/TrEMBL
    E9QMJ8
    Related
    ENSMUSP00000073974.5, ENSMUST00000074370.11
    Conserved Domains (4) summary
    cd08707
    Location:89209
    RGS_Axin; Regulator of G protein signaling (RGS) domain found in the Axin protein
    smart00021
    Location:781863
    DAX; Domain present in Dishevelled and axin
    cd11582
    Location:1180
    Axin_TNKS_binding; Tankyrase binding N-terminal segment of axin
    pfam08833
    Location:464495
    Axin_b-cat_bind; Axin beta-catenin binding domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    26350294..26414784
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006523516.3XP_006523579.1  axin-1 isoform X3

    UniProtKB/TrEMBL
    Q7TMI9
    Conserved Domains (2) summary
    pfam00778
    Location:428503
    DIX; DIX domain
    pfam08833
    Location:108161
    Axin_b-cat_bind; Axin beta-catenin binding domain