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AXIN1 axin 1 [ Homo sapiens (human) ]

Gene ID: 8312, updated on 20-Jan-2019

Summary

Official Symbol
AXIN1provided by HGNC
Official Full Name
axin 1provided by HGNC
Primary source
HGNC:HGNC:903
See related
Ensembl:ENSG00000103126 MIM:603816
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AXIN; PPP1R49
Summary
This gene encodes a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a dishevelled and axin (DIX) domain. The encoded protein interacts with adenomatosis polyposis coli, catenin beta-1, glycogen synthase kinase 3 beta, protein phosphate 2, and itself. This protein functions as a negative regulator of the wingless-type MMTV integration site family, member 1 (WNT) signaling pathway and can induce apoptosis. The crystal structure of a portion of this protein, alone and in a complex with other proteins, has been resolved. Mutations in this gene have been associated with hepatocellular carcinoma, hepatoblastomas, ovarian endometriod adenocarcinomas, and medullablastomas. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Expression
Ubiquitous expression in bone marrow (RPKM 4.6), colon (RPKM 4.0) and 25 other tissues See more
Orthologs

Genomic context

See AXIN1 in Genome Data Viewer
Location:
16p13.3
Exon count:
18
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 16 NC_000016.10 (287440..355226, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (337440..405244, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene Rho GDP dissociation inhibitor gamma Neighboring gene protein disulfide isomerase family A member 2 Neighboring gene mitochondrial ribosomal protein L28 Neighboring gene transmembrane protein 8A

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Caudal duplication anomaly
MedGen: C1842884 OMIM: 607864 GeneReviews: Not available
Compare labs
Hepatocellular carcinoma
MedGen: C2239176 OMIM: 114550 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of axin1 by siRNAs significantly enhances HIV-1 replication in human acute monocytic leukemia cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Tat tat Axin1 regulates HIV-1 Tat-mediated transcription, which requires beta-catenin and TCF4 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • AMER1 mutants destabilize the destruction complex, organism-specific biosystem (from REACTOME)
    AMER1 mutants destabilize the destruction complex, organism-specific biosystemAMER1/WTX is a component of the destruction complex that interacts directly with beta-catenin through its C-terminal half. Depletion of AMER1 through siRNA stabilizes cellular beta-catenin levels an...
  • APC truncation mutants have impaired AXIN binding, organism-specific biosystem (from REACTOME)
    APC truncation mutants have impaired AXIN binding, organism-specific biosystemMutations in the APC tumor suppressor gene are common in colorectal and other cancers and cluster in the central mutation cluster region (MCR) of the gene (Miyoshi et al, 1992; Nagase and Nakamura, ...
  • AXIN missense mutants destabilize the destruction complex, organism-specific biosystem (from REACTOME)
    AXIN missense mutants destabilize the destruction complex, organism-specific biosystemAlterations in AXIN1 have been detected in a number of different cancers including liver and colorectal cancer and medullablastoma, among others (reviewed in Salahshor and Woodgett, 2005). Missense ...
  • AXIN mutants destabilize the destruction complex, activating WNT signaling, organism-specific biosystem (from REACTOME)
    AXIN mutants destabilize the destruction complex, activating WNT signaling, organism-specific biosystemAXIN1 and AXIN2 are critical scaffolding proteins of the beta-catenin destruction complex and make protein-protein interactions with several of the other complex components including APC, GSK3, CK1 a...
  • Apoptosis-related network due to altered Notch3 in ovarian cancer, organism-specific biosystem (from WikiPathways)
    Apoptosis-related network due to altered Notch3 in ovarian cancer, organism-specific biosystemResults of pathway analysis of apoptosis-related genes in OVCAR3 cells treated with Notch3 siRNA or control siRNA.
  • Association Between Physico-Chemical Features and Toxicity Associated Pathways, organism-specific biosystem (from WikiPathways)
    Association Between Physico-Chemical Features and Toxicity Associated Pathways, organism-specific biosystemThis pathway is based on Figure 8 of "Mapping drug physico-chemical features to pathway activity reveals molecular networks linked to toxicity outcome."(See bibliography). These 3 pathways demonstr...
  • Basal cell carcinoma, organism-specific biosystem (from KEGG)
    Basal cell carcinoma, organism-specific biosystemCancer of the skin is the most common cancer in Caucasians and basal cell carcinomas (BCC) account for 90% of all skin cancers. The vast majority of BCC cases are sporadic, though there is a rare fam...
  • Basal cell carcinoma, conserved biosystem (from KEGG)
    Basal cell carcinoma, conserved biosystemCancer of the skin is the most common cancer in Caucasians and basal cell carcinomas (BCC) account for 90% of all skin cancers. The vast majority of BCC cases are sporadic, though there is a rare fam...
  • Beta-catenin phosphorylation cascade, organism-specific biosystem (from REACTOME)
    Beta-catenin phosphorylation cascade, organism-specific biosystemDegradation of beta-catenin is initiated following amino-terminal serine/threonine phosphorylation. Phosphorylation of B-catenin at S45 by CK1 alpha primes the subsequent sequential GSK-3-mediated p...
  • Breast cancer, organism-specific biosystem (from KEGG)
    Breast cancer, organism-specific biosystemBreast cancer is the leading cause of cancer death among women worldwide. The vast majority of breast cancers are carcinomas that originate from cells lining the milk-forming ducts of the mammary gla...
  • Breast cancer, conserved biosystem (from KEGG)
    Breast cancer, conserved biosystemBreast cancer is the leading cause of cancer death among women worldwide. The vast majority of breast cancers are carcinomas that originate from cells lining the milk-forming ducts of the mammary gla...
  • C-MYC pathway, organism-specific biosystem (from Pathway Interaction Database)
    C-MYC pathway, organism-specific biosystem
    C-MYC pathway
  • Canonical Wnt signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
    Canonical Wnt signaling pathway, organism-specific biosystem
    Canonical Wnt signaling pathway
  • Colorectal cancer, organism-specific biosystem (from KEGG)
    Colorectal cancer, organism-specific biosystemColorectal cancer (CRC) is the second largest cause of cancer-related deaths in Western countries. CRC arises from the colorectal epithelium as a result of the accumulation of genetic alterations in ...
  • Colorectal cancer, conserved biosystem (from KEGG)
    Colorectal cancer, conserved biosystemColorectal cancer (CRC) is the second largest cause of cancer-related deaths in Western countries. CRC arises from the colorectal epithelium as a result of the accumulation of genetic alterations in ...
  • DNA Damage Response (only ATM dependent), organism-specific biosystem (from WikiPathways)
    DNA Damage Response (only ATM dependent), organism-specific biosystemThis is the second pathway out of two pathways which deals with DNA damage response. It has two central gene products (ATM and TP53) which are connected with the first DNA damage response pathway. In...
  • Degradation of AXIN, organism-specific biosystem (from REACTOME)
    Degradation of AXIN, organism-specific biosystemAXIN is present in low concentrations in the cell and is considered to be the limiting component of the beta-catenin destruction complex in Xenopus; this may not be the case in mammalian cells, howev...
  • Degradation of beta-catenin by the destruction complex, organism-specific biosystem (from REACTOME)
    Degradation of beta-catenin by the destruction complex, organism-specific biosystemThe beta-catenin destruction complex plays a key role in the canonical Wnt signaling pathway. In the absence of Wnt signaling, this complex controls the levels of cytoplamic beta-catenin. Beta-cateni...
  • Deubiquitination, organism-specific biosystem (from REACTOME)
    Deubiquitination, organism-specific biosystemUbiquitination, the modification of proteins by the covalent attachment of ubiquitin (Ub), is a key regulatory mechanism for many many cellular processes, including protein degradation by the 26S pro...
  • Disassembly of the destruction complex and recruitment of AXIN to the membrane, organism-specific biosystem (from REACTOME)
    Disassembly of the destruction complex and recruitment of AXIN to the membrane, organism-specific biosystemUpon stimulation with WNT ligand, AXIN and GSK3beta are recruited to the plasma membrane through interaction with DVL (Tamai et al, 2004; Mao et al, 2001; reviewed in He et al, 2004). Polymerization...
  • Disease, organism-specific biosystem (from REACTOME)
    Disease, organism-specific biosystemBiological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular ...
  • Diseases of signal transduction, organism-specific biosystem (from REACTOME)
    Diseases of signal transduction, organism-specific biosystemSignaling processes are central to human physiology (e.g., Pires-da Silva & Sommer 2003), and their disruption by either germ-line and somatic mutation can lead to serious disease. Here, the molecula...
  • Endometrial cancer, organism-specific biosystem (from KEGG)
    Endometrial cancer, organism-specific biosystemEndometrial cancer (EC) is the most common gynaecological malignancy and the fourth most common malignancy in women in the developed world after breast, colorectal and lung cancer. Two types of endom...
  • Endometrial cancer, conserved biosystem (from KEGG)
    Endometrial cancer, conserved biosystemEndometrial cancer (EC) is the most common gynaecological malignancy and the fourth most common malignancy in women in the developed world after breast, colorectal and lung cancer. Two types of endom...
  • Extracellular vesicle-mediated signaling in recipient cells, organism-specific biosystem (from WikiPathways)
    Extracellular vesicle-mediated signaling in recipient cells, organism-specific biosystemProtein sorting during formation of multivesicular bodies results in packaging of key molecules in exosomes. Exosomes bound-signaling ligands once released from host cells interacts with the receptor...
  • Hippo signaling pathway, organism-specific biosystem (from KEGG)
    Hippo signaling pathway, organism-specific biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
  • Hippo signaling pathway, conserved biosystem (from KEGG)
    Hippo signaling pathway, conserved biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
  • Mesodermal Commitment Pathway, organism-specific biosystem (from WikiPathways)
    Mesodermal Commitment Pathway, organism-specific biosystemModel depicting mesodermal specification based on the literature and highly enriched gene expression profiles via comparison across dozens of independent induced and embryonic pluripotent stem cell l...
  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • Misspliced GSK3beta mutants stabilize beta-catenin, organism-specific biosystem (from REACTOME)
    Misspliced GSK3beta mutants stabilize beta-catenin, organism-specific biosystemGSK3beta is subject to in-frame missplicing in CML stem cells resulting in the production of mutant protein that lacks the AXIN and FRAT binding domains. Cells containing this mutant GSK3beta show e...
  • N-cadherin signaling events, organism-specific biosystem (from Pathway Interaction Database)
    N-cadherin signaling events, organism-specific biosystem
    N-cadherin signaling events
  • Neural Crest Differentiation, organism-specific biosystem (from WikiPathways)
    Neural Crest Differentiation, organism-specific biosystemGene regulatory network model of cranial neural crest cell (CNCC) development, adaped from PMID: 19575671. Most interactions in the model are proposed to regulate transcription of core factors involv...
  • Pathways in cancer, organism-specific biosystem (from KEGG)
    Pathways in cancer, organism-specific biosystem
    Pathways in cancer
  • Post-translational protein modification, organism-specific biosystem (from REACTOME)
    Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...
  • Presenilin action in Notch and Wnt signaling, organism-specific biosystem (from Pathway Interaction Database)
    Presenilin action in Notch and Wnt signaling, organism-specific biosystem
    Presenilin action in Notch and Wnt signaling
  • Regulation of Wnt/B-catenin Signaling by Small Molecule Compounds, organism-specific biosystem (from WikiPathways)
    Regulation of Wnt/B-catenin Signaling by Small Molecule Compounds, organism-specific biosystemThe Wnt/B-catenin pathway begins with Wnt family activation by MBOAT that allows Wnt proteins to translocate out of a cell and bind to FZD and LRP to form a complex. This complex stimulates B-catenin...
  • S33 mutants of beta-catenin aren't phosphorylated, organism-specific biosystem (from REACTOME)
    S33 mutants of beta-catenin aren't phosphorylated, organism-specific biosystemS33 mutations of beta-catenin interfere with GSK3 phosphorylation and result in stabilization and nuclear localization of the protein and enhanced WNT signaling (Groen et al, 2008; Nhieu et al, 1999;...
  • S37 mutants of beta-catenin aren't phosphorylated, organism-specific biosystem (from REACTOME)
    S37 mutants of beta-catenin aren't phosphorylated, organism-specific biosystemS37 mutations of beta-catenin interfere with GSK3 phosphorylation and stabilize the protein, resulting in enhanced WNT pathway signaling (Nhieu et al, 1999; Clements et al, 2002; reviewed in Polakis,...
  • S45 mutants of beta-catenin aren't phosphorylated, organism-specific biosystem (from REACTOME)
    S45 mutants of beta-catenin aren't phosphorylated, organism-specific biosystemS45 mutants of beta-catenin have been identified in colorectal and hepatocellular carcinomas, soft tissue cancer and Wilms Tumors, among others (reviewed in Polakis, 2000). These mutations abolish th...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by WNT in cancer, organism-specific biosystem (from REACTOME)
    Signaling by WNT in cancer, organism-specific biosystemThe WNT signaling pathway has been linked with cancer ever since the identification of the first WNT as a gene activated by integration of mouse mammary tumor virus proviral DNA in virally-induced br...
  • Signaling by Wnt, organism-specific biosystem (from REACTOME)
    Signaling by Wnt, organism-specific biosystemWNT signaling pathways control a wide range of developmental and adult process in metozoans including cell proliferation, cell fate decisions, cell polarity and stem cell maintenance (reviewed in Sai...
  • Signaling pathways regulating pluripotency of stem cells, organism-specific biosystem (from KEGG)
    Signaling pathways regulating pluripotency of stem cells, organism-specific biosystemPluripotent stem cells (PSCs) are basic cells with an indefinite self-renewal capacity and the potential to generate all the cell types of the three germinal layers. The types of PSCs known to date i...
  • Signaling pathways regulating pluripotency of stem cells, conserved biosystem (from KEGG)
    Signaling pathways regulating pluripotency of stem cells, conserved biosystemPluripotent stem cells (PSCs) are basic cells with an indefinite self-renewal capacity and the potential to generate all the cell types of the three germinal layers. The types of PSCs known to date i...
  • T41 mutants of beta-catenin aren't phosphorylated, organism-specific biosystem (from REACTOME)
    T41 mutants of beta-catenin aren't phosphorylated, organism-specific biosystemT41 mutations of beta-catenin interfere with GSK3 phosphorylation and result in stabilization and nuclear accumulation of the protein (Moreno-Bueno et al, 2002; Taniguchi et al, 2002; reviewed in Pol...
  • TCF dependent signaling in response to WNT, organism-specific biosystem (from REACTOME)
    TCF dependent signaling in response to WNT, organism-specific biosystem19 WNT ligands and 10 FZD receptors have been identified in human cells; interactions amongst these ligands and receptors vary in a developmental and tissue-specific manner and lead to activation of ...
  • TGF-beta Signaling Pathway, organism-specific biosystem (from WikiPathways)
    TGF-beta Signaling Pathway, organism-specific biosystemThe signal transduction mechanisms underlying the pathophysiological activities of transforming growth factor-? (TGF-?) have been extensively studied since its discovery nearly 30 years ago. TGF-? li...
  • TGF-beta receptor signaling, organism-specific biosystem (from Pathway Interaction Database)
    TGF-beta receptor signaling, organism-specific biosystem
    TGF-beta receptor signaling
  • Truncations of AMER1 destabilize the destruction complex, organism-specific biosystem (from REACTOME)
    Truncations of AMER1 destabilize the destruction complex, organism-specific biosystemAMER1/WTX is a known component of the destruction complex and interacts directly with beta-catenin through the C-terminal half (Major et al, 2007). siRNA depletion of AMER1 in mammalian cells stabil...
  • Ub-specific processing proteases, organism-specific biosystem (from REACTOME)
    Ub-specific processing proteases, organism-specific biosystemUb-specific processing proteases (USPs) are the largest of the DUB families with more than 50 members in humans. The USP catalytic domain varies considerably in size and consists of six conserved mo...
  • Wnt Signaling Pathway, organism-specific biosystem (from WikiPathways)
    Wnt Signaling Pathway, organism-specific biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
  • Wnt Signaling Pathway Netpath, organism-specific biosystem (from WikiPathways)
    Wnt Signaling Pathway Netpath, organism-specific biosystemWNT signal, through the canonical pathway, controls cell fate determination and through the non-canonical pathway controls cell movement and tissue polarity. The name "wnt" is a fusion of two terms, ...
  • Wnt Signaling Pathway and Pluripotency, organism-specific biosystem (from WikiPathways)
    Wnt Signaling Pathway and Pluripotency, organism-specific biosystemThis pathway was adapted from several resources and is designed to provide a theoretical frame-work for examining Wnt signaling and interacting components in the context of embryonic stem-cell plurip...
  • Wnt signaling pathway, organism-specific biosystem (from KEGG)
    Wnt signaling pathway, organism-specific biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
  • Wnt signaling pathway, conserved biosystem (from KEGG)
    Wnt signaling pathway, conserved biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
  • phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex, organism-specific biosystem (from REACTOME)
    phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex, organism-specific biosystemMutations in exon 3 of the beta-catenin gene have been identified in a number of human cancers (Morin et al, 1997; Rubinfeld et al, 1997; reviewed in Polakis, 2000; Polakis, 2007). These mutations g...
  • truncated APC mutants destabilize the destruction complex, organism-specific biosystem (from REACTOME)
    truncated APC mutants destabilize the destruction complex, organism-specific biosystemAPC is a large and central component of the destruction complex, which limits signaling in the absence of WNT ligand by promoting the ubiquitin-mediated degradation of beta-catenin. APC interacts wi...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC52315

Gene Ontology Provided by GOA

Function Evidence Code Pubs
I-SMAD binding IPI
Inferred from Physical Interaction
more info
PubMed 
SMAD binding IPI
Inferred from Physical Interaction
more info
PubMed 
armadillo repeat domain binding ISS
Inferred from Sequence or Structural Similarity
more info
 
beta-catenin binding IDA
Inferred from Direct Assay
more info
PubMed 
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
identical protein binding ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
 
protein kinase binding ISS
Inferred from Sequence or Structural Similarity
more info
 
protein-containing complex scaffold activity IDA
Inferred from Direct Assay
more info
PubMed 
protein-containing complex scaffold activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
receptor signaling complex scaffold activity IEA
Inferred from Electronic Annotation
more info
 
signaling adaptor activity TAS
Traceable Author Statement
more info
PubMed 
ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
Wnt signaling pathway TAS
Traceable Author Statement
more info
 
activation of protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
beta-catenin destruction complex assembly TAS
Traceable Author Statement
more info
 
beta-catenin destruction complex disassembly TAS
Traceable Author Statement
more info
 
cellular protein-containing complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of canonical Wnt signaling pathway IC
Inferred by Curator
more info
PubMed 
negative regulation of canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of JNK cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of canonical Wnt signaling pathway TAS
Traceable Author Statement
more info
 
positive regulation of peptidyl-serine phosphorylation NAS
Non-traceable Author Statement
more info
PubMed 
positive regulation of peptidyl-threonine phosphorylation NAS
Non-traceable Author Statement
more info
PubMed 
positive regulation of protein catabolic process IC
Inferred by Curator
more info
PubMed 
positive regulation of protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein ubiquitination NAS
Non-traceable Author Statement
more info
PubMed 
positive regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of ubiquitin-protein transferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of Wnt signaling pathway TAS
Traceable Author Statement
more info
 
regulation of intracellular estrogen receptor signaling pathway TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
beta-catenin destruction complex IDA
Inferred from Direct Assay
more info
PubMed 
cell periphery IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic vesicle ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosol TAS
Traceable Author Statement
more info
 
lateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
axin-1
Names
axis inhibition protein 1
axis inhibitor 1
fused, mouse, homolog of
protein phosphatase 1, regulatory subunit 49

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012267.1 RefSeqGene

    Range
    4789..70025
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_003502.4NP_003493.1  axin-1 isoform a

    See identical proteins and their annotated locations for NP_003493.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript, and encodes the longer isoform (a). An upstream in-frame AUG is present that could extend the N-terminus of this isoform by 49 aa; however, there is no evidence that the upstream AUG is used, so the shorter N-terminus is being annotated.
    Source sequence(s)
    AC005202, AF009674, BC035872, DB460285, Z69667, Z99754
    Consensus CDS
    CCDS10405.1
    UniProtKB/Swiss-Prot
    O15169
    UniProtKB/TrEMBL
    A0A0S2Z4R0
    Related
    ENSP00000262320.3, ENST00000262320.7
    Conserved Domains (4) summary
    cd08707
    Location:89209
    RGS_Axin; Regulator of G protein signaling (RGS) domain found in the Axin protein
    cd11582
    Location:1180
    Axin_TNKS_binding; Tankyrase binding N-terminal segment of axin
    pfam00778
    Location:782857
    DIX; DIX domain
    pfam08833
    Location:464520
    Axin_b-cat_bind; Axin beta-catenin binding domain
  2. NM_181050.2NP_851393.1  axin-1 isoform b

    See identical proteins and their annotated locations for NP_851393.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the 3' coding region, compared to variant 1. The resulting protein (isoform b) is shorter, compared to isoform a. An upstream in-frame AUG is present that could extend the N-terminus of this isoform by 49 aa; however, there is no evidence that the upstream AUG is used, so the shorter N-terminus is being annotated.
    Source sequence(s)
    AC005202, BC035872, BC044648, DB460285, Z69667
    Consensus CDS
    CCDS10406.1
    UniProtKB/Swiss-Prot
    O15169
    UniProtKB/TrEMBL
    A0A0S2Z4S3
    Related
    ENSP00000346935.3, ENST00000354866.7
    Conserved Domains (4) summary
    cd08707
    Location:89209
    RGS_Axin; Regulator of G protein signaling (RGS) domain found in the Axin protein
    cd11582
    Location:1180
    Axin_TNKS_binding; Tankyrase binding N-terminal segment of axin
    pfam00778
    Location:746821
    DIX; DIX domain
    pfam08833
    Location:464520
    Axin_b-cat_bind; Axin beta-catenin binding domain

RNA

  1. NR_134879.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    BC035872, KF615852

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p12 Primary Assembly

    Range
    287440..355226 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011522684.2XP_011520986.1  axin-1 isoform X5

    Conserved Domains (4) summary
    cd08707
    Location:89209
    RGS_Axin; Regulator of G protein signaling (RGS) domain found in the Axin protein
    cd11582
    Location:1180
    Axin_TNKS_binding; Tankyrase binding N-terminal segment of axin
    pfam00778
    Location:787862
    DIX; DIX domain
    pfam08833
    Location:469525
    Axin_b-cat_bind; Axin beta-catenin binding domain
  2. XM_017023743.1XP_016879232.1  axin-1 isoform X2

  3. XM_011522682.2XP_011520984.1  axin-1 isoform X1

    Conserved Domains (4) summary
    cd08707
    Location:138258
    RGS_Axin; Regulator of G protein signaling (RGS) domain found in the Axin protein
    cd11582
    Location:60129
    Axin_TNKS_binding; Tankyrase binding N-terminal segment of axin
    pfam00778
    Location:836911
    DIX; DIX domain
    pfam08833
    Location:518574
    Axin_b-cat_bind; Axin beta-catenin binding domain
  4. XM_017023744.1XP_016879233.1  axin-1 isoform X4

  5. XM_011522683.2XP_011520985.1  axin-1 isoform X3

    Conserved Domains (4) summary
    cd08707
    Location:138258
    RGS_Axin; Regulator of G protein signaling (RGS) domain found in the Axin protein
    cd11582
    Location:60129
    Axin_TNKS_binding; Tankyrase binding N-terminal segment of axin
    pfam00778
    Location:800875
    DIX; DIX domain
    pfam08833
    Location:518574
    Axin_b-cat_bind; Axin beta-catenin binding domain
  6. XM_017023745.2XP_016879234.1  axin-1 isoform X6

  7. XM_011522686.1XP_011520988.1  axin-1 isoform X7

    Conserved Domains (2) summary
    pfam00778
    Location:501576
    DIX; DIX domain
    pfam08833
    Location:183239
    Axin_b-cat_bind; Axin beta-catenin binding domain
  8. XM_017023746.1XP_016879235.1  axin-1 isoform X8

    Conserved Domains (2) summary
    pfam00778
    Location:432507
    DIX; DIX domain
    pfam08833
    Location:114170
    Axin_b-cat_bind; Axin beta-catenin binding domain
  9. XM_017023747.1XP_016879236.1  axin-1 isoform X9

  10. XM_017023748.1XP_016879237.1  axin-1 isoform X10

RNA

  1. XR_001751996.1 RNA Sequence

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