Conserved Protein Domain Family
RGS_Axin

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cd08707: RGS_Axin 
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Regulator of G protein signaling (RGS) domain found in the Axin protein
The RGS (Regulator of G-protein Signaling) domain is an essential part of the Axin protein. Axin is a member of the RA/RGS subfamily of the RGS protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, and skeletal and muscle development. The RGS domain of Axin is specifically interacts with the heterotrimeric G-alpha12 protein, but not with closely related G-alpha13, and provides a unique tool to regulate G-alpha12-mediated signaling processes. The RGS domain of Axin also interacts with the tumor suppressor protein APC (Adenomatous Polyposis Coli) in order to control the cytoplasmic level of the proto-oncogene, beta-catenin.
BioAssay Targets and Results
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CID: 3137736
AID: 525200
GI: 20532378
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Effect on interaction between Axin1-GFP and Lrp2 in HEK293 cells transfected with LRP6-myc and Axin2-myc cDNAs at 10 uM by western blot analysis
Target Name: Axin-1
Chemical Name: IWR-1-endo
Statistics
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PSSM-Id: 188662
View PSSM: cd08707
Aligned: 7 rows
Threshold Bit Score: 182.66
Threshold Setting Gi: 121992193
Created: 13-May-2009
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
Hierarchy
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Display:
 
APC binding
Conserved site includes 18 residues -Click on image for an interactive view with Cn3D
Feature 1:APC binding site [polypeptide binding site]
Evidence:
  • Structure:1EMU: Homo sapiens Axin RGS binds a SAMP repeat; contacts at 4 A
    View structure with Cn3D
  • Comment: 25 amino acid fragment of APC (adenomatous polyposis coli) called the SAMP repeat is sufficient for full Axin binding

cd08707 is part of a hierarchy of related CD models.
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cd08707 is a member of the superfamily cl02565.
cd07440:RGScd08705:RGS_R7-likecd08706:RGS_R12-likecd08707:RGS_Axincd08708:RGS_FLBAcd08709:RGS_RGS2cd08710:RGS_RGS16cd08711:RGS_RGS8cd08712:RGS_RGS18cd08713:RGS_RGS3cd08714:RGS_RGS4cd08715:RGS_RGS1cd08716:RGS_RGS13cd08717:RGS_RGS5cd08718:RGS_RZ-likecd08719:RGS_SNX13cd08720:RGS_SNX25cd08721:RGS_AKAP2_2cd08722:RGS_SNX14cd08723:RGS_RGS21cd08724:RGS_GRK-likecd08725:RGS_RGS22_4cd08726:RGS_RGS22_3cd08727:RGS_RGS22_2cd08728:RGS-like_2cd08729:RGS_PXcd08730:RGS-like_3cd08731:RGS_RGS22_1cd08732:RGS-like_4cd08734:RGS-like_1cd08735:RGS_AKAP2_1cd08736:RGS_RhoGEF-likecd08737:RGS_RGS6cd08738:RGS_RGS7cd08739:RGS_RGS9cd08740:RGS_RGS11cd08741:RGS_RGS10cd08742:RGS_RGS12cd08743:RGS_RGS14cd08744:RGS_RGS17cd08745:RGS_RGS19cd08746:RGS_RGS20cd08747:RGS_GRK2_GRK3cd08748:RGS_GRK1cd08749:RGS_GRK7cd08750:RGS_GRK4cd08751:RGS_GRK6cd08752:RGS_GRK5cd08753:RGS_PDZRhoGEFcd08754:RGS_LARGcd08755:RGS_p115RhoGEFcd08756:RGS_GEF_like12199219374910637821980351DK8 A1EMU A822667488220363512199219374910637821980351DK8 A1EMU A8226674882203635
cd08707 Sequence Cluster
cd08707 Sequence Cluster
Sub-family Hierarchy
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 cd08707 Branch
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CD Hierarchy
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1            ####  #                  #  ##  ## #            ## ### ##                   
1DK8_A        16 LHSLLDDQDGISLFRTFLKQEGCA--DLLDFWFACTGFRKlepcdsneekRLKLARAIYRKYIldnngivsrQTKPATKS 93
1EMU_A        10 LHSLLDDQDGISLFRTFLKQEGCA--DLLDFWFACTGFRKlepcdsneekRLKLARAIYRKYIldnngivsrQTKPATKS 87
gi 74910637   92 LHALLSDEDGIQLFKHYLIQEGAE--NPLLFWLATQGFKKksds---dpvRTDLAKLIYRRFIkkdg-qqvvRLHGSTRN 165
gi 82198035   73 LNLLLDDQDGATLFRMYLEGEGLG--DLLSFWFACNGFRAmdps---epkTSKTAKAIYRWYVqnss-avlcRLKPSTRT 146
gi 82203635   86 LHSLLGDQDGAYLFRTFLEREKCV--DTLDFWFACNGFRQmdlk---dtkTSRVAKAIYKRYIenns-ivskQLKPATKT 159
gi 82266748   90 LHSLLDDQEGIHLFRNFLCQEGCA--DLLDFWFACSGFRKtsq-----ekRAKLAKAIYRKYIvdgggivsrQIKAATKS 162
gi 121992193  58 LNHLLEDRDGVELFKKYVEEEAPAynDHLNFYFACEGLKQqtd----pekVKQIIGAIYRFLRksql-sisdDLRTQIKA 132
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
Feature 1                                                   
1DK8_A        94 FIKGcimkqlidPAMFDQAQTEIQATMEENTYPSFLKSDIYLE 136
1EMU_A        88 FIKGcimkqlidPAMFDQAQTEIQATMEENTYPSFLKSDIYLE 130
gi 74910637  166 HVAEsirtnkvdSNLFDASQMEVEEYMRETSYPMFLKSDVYVQ 208
gi 82198035  147 QVKEcvknqqlnKTVFDQAQQEIQRAMEQEAFTSFLQSDICKE 189
gi 82203635  160 YIRDsikkqqidSIMFDQAQTEIQTVMEENAYQMFLTSDIYLE 202
gi 82266748  163 FIRDcvgrphpdPAMFEQAQIEIQSMMEENTYPLFLKSDLYLE 205
gi 121992193 133 IKSNpel--plsPHIFDPMQHHVETTIRDNIYPTFLCSEMYIL 173

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