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Klf16 Kruppel-like transcription factor 16 [ Mus musculus (house mouse) ]

Gene ID: 118445, updated on 30-Apr-2024

Summary

Official Symbol
Klf16provided by MGI
Official Full Name
Kruppel-like transcription factor 16provided by MGI
Primary source
MGI:MGI:2153049
See related
Ensembl:ENSMUSG00000035397 AllianceGenome:MGI:2153049
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DRRF; BTEB4
Summary
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Acts upstream of or within dopamine receptor signaling pathway and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in several structures, including brain; embryo mesenchyme; genitourinary system; gut; and retina. Orthologous to human KLF16 (Kruppel like factor 16). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 29.6), adrenal adult (RPKM 21.3) and 28 other tissues See more
Orthologs
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Genomic context

See Klf16 in Genome Data Viewer
Location:
10 C1; 10 39.72 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (80402955..80413130, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (80567121..80577296, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene ATPase, class I, type 8B, member 3 Neighboring gene STARR-positive B cell enhancer ABC_E1124 Neighboring gene REX1, RNA exonuclease 1 Neighboring gene predicted gene, 31057 Neighboring gene STARR-positive B cell enhancer ABC_E10628 Neighboring gene STARR-positive B cell enhancer mm9_chr10:80032416-80032717 Neighboring gene STARR-positive B cell enhancer ABC_E11446 Neighboring gene predicted gene, 26710 Neighboring gene abhydrolase domain containing 17A

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
Krueppel-like factor 16
Names
BTE-binding protein 4
Kruppel-like factor 16
basic transcription element-binding protein 4
dopamine receptor regulating factor
transcription factor BTEB4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_078477.2NP_510962.2  Krueppel-like factor 16

    See identical proteins and their annotated locations for NP_510962.2

    Status: VALIDATED

    Source sequence(s)
    AC152058, AK044577
    Consensus CDS
    CCDS24026.1
    UniProtKB/Swiss-Prot
    P58334, Q3U3Y4, Q8C8S2
    UniProtKB/TrEMBL
    B2RPU7
    Related
    ENSMUSP00000048825.9, ENSMUST00000038558.9
    Conserved Domains (3) summary
    COG5048
    Location:124186
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:128150
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:172197
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    80402955..80413130 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)