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CLCA1 chloride channel accessory 1 [ Homo sapiens (human) ]

Gene ID: 1179, updated on 8-Jul-2021

Summary

Official Symbol
CLCA1provided by HGNC
Official Full Name
chloride channel accessory 1provided by HGNC
Primary source
HGNC:HGNC:2015
See related
Ensembl:ENSG00000016490 MIM:603906
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CACC; GOB5; CACC1; CLCRG1; CaCC-1; hCLCA1; hCaCC-1
Summary
This gene encodes a member of the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same region on chromosome 1p31-p22 and share a high degree of homology in size, sequence, and predicted structure, but differ significantly in their tissue distributions. The encoded protein is expressed as a precursor protein that is processed into two cell-surface-associated subunits, although the site at which the precursor is cleaved has not been precisely determined. The encoded protein may be involved in mediating calcium-activated chloride conductance in the intestine. [provided by RefSeq, Jul 2008]
Expression
Biased expression in small intestine (RPKM 634.9), duodenum (RPKM 392.5) and 2 other tissues See more
Orthologs
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Genomic context

See CLCA1 in Genome Data Viewer
Location:
1p22.3
Exon count:
14
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (86468927..86500259)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (86934610..86965942)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein L7 like 1 pseudogene Neighboring gene chloride channel accessory 2 Neighboring gene uncharacterized LOC105378827 Neighboring gene uncharacterized LOC105378826

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 from both CCR5- and CXCR4-tropic HIV-1 strains opens calcium-activated potassium (K(Ca)), chloride, and calcium-permeant nonselective cation channels in macrophages; these signals are mediated by CCR5 and CXCR4 PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • FLJ95147

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables chloride channel activity TAS
Traceable Author Statement
more info
PubMed 
enables intracellular calcium activated chloride channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metalloendopeptidase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
involved_in calcium ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to hypoxia IEA
Inferred from Electronic Annotation
more info
 
involved_in chloride transport IEA
Inferred from Electronic Annotation
more info
 
involved_in ion transmembrane transport TAS
Traceable Author Statement
more info
 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in microvillus IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in zymogen granule membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
calcium-activated chloride channel regulator 1
Names
CLCA family member 1, chloride channel regulator
calcium-activated chloride channel family member 1
calcium-activated chloride channel protein 1
calcium-dependent chloride channel-1
chloride channel regulator 1
chloride channel, calcium activated, family member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001285.4NP_001276.3  calcium-activated chloride channel regulator 1 precursor

    Status: REVIEWED

    Source sequence(s)
    AF127036, AL122002, DA428844
    Consensus CDS
    CCDS709.1
    Related
    ENSP00000378200.1, ENST00000394711.2
    Conserved Domains (1) summary
    TIGR00868
    Location:1861
    hCaCC; calcium-activated chloride channel protein 1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    86468927..86500259
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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