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TAGAP T cell activation RhoGTPase activating protein [ Homo sapiens (human) ]

Gene ID: 117289, updated on 17-Jun-2019

Summary

Official Symbol
TAGAPprovided by HGNC
Official Full Name
T cell activation RhoGTPase activating proteinprovided by HGNC
Primary source
HGNC:HGNC:15669
See related
Ensembl:ENSG00000164691 MIM:609667
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FKSG15; IDDM21; TAGAP1; ARHGAP47
Summary
This gene encodes a member of the Rho GTPase-activator protein superfamily. The encoded protein may function as a Rho GTPase-activating protein. Alterations in this gene may be associated with several diseases, including rheumatoid arthritis, celiac disease, and multiple sclerosis. Alternate splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2013]
Expression
Biased expression in bone marrow (RPKM 44.8), lymph node (RPKM 19.7) and 10 other tissues See more
Orthologs

Genomic context

See TAGAP in Genome Data Viewer
Location:
6q25.3
Exon count:
10
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (159034468..159045152, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (159455500..159466184, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 293, pseudogene Neighboring gene radial spoke head 3 Neighboring gene uncharacterized LOC105378083 Neighboring gene uncharacterized LOC107986664 Neighboring gene uncharacterized LOC112267968 Neighboring gene VISTA enhancer hs2576

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A meta-analysis of genome-wide association scans identifies IL18RAP, PTPN2, TAGAP, and PUS10 as shared risk loci for Crohn's disease and celiac disease.
NHGRI GWA Catalog
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
NHGRI GWA Catalog
Genetics of rheumatoid arthritis contributes to biology and drug discovery.
NHGRI GWA Catalog
Genome-wide association study of celiac disease in North America confirms FRMD4B as new celiac locus.
NHGRI GWA Catalog
Genome-wide interaction study of smoking and bladder cancer risk.
NHGRI GWA Catalog
Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci.
NHGRI GWA Catalog
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
NHGRI GWA Catalog
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
NHGRI GWA Catalog
Multiple common variants for celiac disease influencing immune gene expression.
NHGRI GWA Catalog
Newly identified genetic risk variants for celiac disease related to the immune response.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat downregulates the expression of T-cell activation RhoGTPase activating protein (TAGAP) in human primary T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Rho GTPase cycle, organism-specific biosystem (from REACTOME)
    Rho GTPase cycle, organism-specific biosystemThe cycling of Rho GTPases is tightly controlled by three classes of protein. These are (1) guanine nucleotide dissociation inhibitors or GDIs, which maintain Rho proteins in an inactive state in the...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by Rho GTPases, organism-specific biosystem (from REACTOME)
    Signaling by Rho GTPases, organism-specific biosystemThe Rho family of small guanine nucleotide binding proteins is one of five generally recognized branches of the Ras superfamily. Like most Ras superfamily members, typical Rho proteins function as bi...

General gene information

Markers

Homology

Clone Names

  • FLJ32631, FLJ39771, MGC27381, MGC133247

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
regulation of small GTPase mediated signal transduction TAS
Traceable Author Statement
more info
 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
T-cell activation Rho GTPase-activating protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011524.1 RefSeqGene

    Range
    5001..15685
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001278733.2NP_001265662.1  T-cell activation Rho GTPase-activating protein isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate 5'-most exon, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 2. The encoded isoform (d) has a shorter N-terminus, compared to isoform b.
    Source sequence(s)
    AF385429, AL035530, DA819174
    UniProtKB/Swiss-Prot
    Q8N103
    Conserved Domains (1) summary
    cd04402
    Location:22218
    RhoGAP_ARHGAP20; RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP20-like proteins. ArhGAP20, also known as KIAA1391 and RA-RhoGAP, contains a RhoGAP, a RA, and a PH domain, and ANXL repeats. ArhGAP20 is activated by ...
  2. NM_054114.5NP_473455.2  T-cell activation Rho GTPase-activating protein isoform b

    See identical proteins and their annotated locations for NP_473455.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) encodes the longest isoform (b).
    Source sequence(s)
    AF385429, AL035530
    Consensus CDS
    CCDS5261.1
    UniProtKB/Swiss-Prot
    Q8N103
    Related
    ENSP00000356033.3, ENST00000367066.7
    Conserved Domains (1) summary
    cd04402
    Location:85281
    RhoGAP_ARHGAP20; RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP20-like proteins. ArhGAP20, also known as KIAA1391 and RA-RhoGAP, contains a RhoGAP, a RA, and a PH domain, and ANXL repeats. ArhGAP20 is activated by ...
  3. NM_138810.4NP_620165.1  T-cell activation Rho GTPase-activating protein isoform c

    See identical proteins and their annotated locations for NP_620165.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks several exons and its 3' terminal exon extends past a splice site that is used in variant 2. The encoded isoform (c) has a shorter and distinct C-terminus, compared to isoform b.
    Source sequence(s)
    AF385429, AL035530, BC015859
    Consensus CDS
    CCDS5263.1
    UniProtKB/Swiss-Prot
    Q8N103
    Related
    ENSP00000340217.5, ENST00000338313.5
    Conserved Domains (1) summary
    cd04402
    Location:85264
    RhoGAP_ARHGAP20; RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP20-like proteins. ArhGAP20, also known as KIAA1391 and RA-RhoGAP, contains a RhoGAP, a RA, and a PH domain, and ANXL repeats. ArhGAP20 is activated by ...
  4. NM_152133.2NP_687034.1  T-cell activation Rho GTPase-activating protein isoform a

    See identical proteins and their annotated locations for NP_687034.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) lacks an exon in the coding region compared to variant 2, resulting in the use of a downstream start codon. The encoded isoform (a) has a shorter N-terminus compared to isoform b.
    Source sequence(s)
    AF385430, AL035530
    Consensus CDS
    CCDS5262.1
    UniProtKB/Swiss-Prot
    Q8N103
    Related
    ENSP00000322650.6, ENST00000326965.7
    Conserved Domains (1) summary
    cl02570
    Location:1103
    RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    159034468..159045152 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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