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Steap4 STEAP family member 4 [ Mus musculus (house mouse) ]

Gene ID: 117167, updated on 8-Dec-2022

Summary

Official Symbol
Steap4provided by MGI
Official Full Name
STEAP family member 4provided by MGI
Primary source
MGI:MGI:1923560
See related
Ensembl:ENSMUSG00000012428 AllianceGenome:MGI:1923560
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tiarp; Tnfaip9; 1110021O17Rik
Summary
Enables cupric reductase activity and ferric-chelate reductase (NADPH) activity. Acts upstream of or within fat cell differentiation and transition metal ion transport. Located in endosome and plasma membrane. Is expressed in brain. Orthologous to human STEAP4 (STEAP4 metalloreductase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in subcutaneous fat pad adult (RPKM 70.3), mammary gland adult (RPKM 51.7) and 9 other tissues See more
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Genomic context

See Steap4 in Genome Data Viewer
Location:
5; 5 A1
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (8010472..8032213)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (7960472..7982213)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene lin-37 homolog pseudogene Neighboring gene predicted gene, 30835 Neighboring gene predicted gene, 52802 Neighboring gene predicted gene 15731 Neighboring gene 60S ribosomal protein L27 pseudogene Neighboring gene sorcin

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

General gene information

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables FAD binding ISO
Inferred from Sequence Orthology
more info
 
enables cupric reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cupric reductase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables electron transfer activity ISO
Inferred from Sequence Orthology
more info
 
enables ferric-chelate reductase (NADPH) activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ferric-chelate reductase (NADPH) activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ferric-chelate reductase (NADPH) activity ISO
Inferred from Sequence Orthology
more info
 
enables heme binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
metalloreductase STEAP4
Names
Tnfa-induced adipose-related protein
dudulin 4
six-transmembrane epithelial antigen of prostate 4
tumor necrosis factor, alpha-induced protein 9
tumor necrosis factor-alpha-induced adipose-related protein
NP_473439.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_054098.3NP_473439.2  metalloreductase STEAP4

    See identical proteins and their annotated locations for NP_473439.2

    Status: PROVISIONAL

    Source sequence(s)
    AC133514
    Consensus CDS
    CCDS39008.1
    UniProtKB/Swiss-Prot
    Q91ZE8, Q923B6
    Related
    ENSMUSP00000111081.2, ENSMUST00000115421.3
    Conserved Domains (3) summary
    COG2085
    Location:24201
    COG2085; Predicted dinucleotide-binding enzyme [General function prediction only]
    pfam01794
    Location:251318
    Ferric_reduct; Ferric reductase like transmembrane component
    cl21454
    Location:26190
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    8010472..8032213
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)