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STEAP4 STEAP4 metalloreductase [ Homo sapiens (human) ]

Gene ID: 79689, updated on 13-Mar-2020

Summary

Official Symbol
STEAP4provided by HGNC
Official Full Name
STEAP4 metalloreductaseprovided by HGNC
Primary source
HGNC:HGNC:21923
See related
Ensembl:ENSG00000127954 MIM:611098
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TIARP; STAMP2; SchLAH; TNFAIP9
Summary
The protein encoded by this gene belongs to the STEAP (six transmembrane epithelial antigen of prostate) family, and resides in the golgi apparatus. It functions as a metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+), using NAD(+) as acceptor. Studies in mice and human suggest that this gene maybe involved in adipocyte development and metabolism, and may contribute to the normal biology of the prostate cell, as well as prostate cancer progression. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2011]
Expression
Broad expression in fat (RPKM 50.0), prostate (RPKM 32.8) and 17 other tissues See more
Orthologs

Genomic context

See STEAP4 in Genome Data Viewer
Location:
7q21.12
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (88270892..88306894, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (87905744..87936228, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene ADAM metallopeptidase domain 22 Neighboring gene uncharacterized LOC105375386 Neighboring gene SRI antisense RNA 1 Neighboring gene sorcin Neighboring gene uncharacterized LOC107986815 Neighboring gene eukaryotic translation initiation factor 4A1 pseudogene 13

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Microarray analysis indicates HIV-1 Tat-induced upregulation of STEAP family member 4 (STEAP4; TNFAIP9) in primary human brain microvascular endothelial cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ23153, DKFZp666D049

Gene Ontology Provided by GOA

Function Evidence Code Pubs
FAD binding IDA
Inferred from Direct Assay
more info
PubMed 
cupric reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
electron transfer activity IDA
Inferred from Direct Assay
more info
PubMed 
ferric-chelate reductase (NADPH) activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ferric-chelate reductase (NADPH) activity IDA
Inferred from Direct Assay
more info
PubMed 
heme binding IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
copper ion import IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
electron transport chain IEA
Inferred from Electronic Annotation
more info
 
fat cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
ferric iron import across cell outer membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
iron ion homeostasis IEA
Inferred from Electronic Annotation
more info
 
oxidation-reduction process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein homotrimerization IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
early endosome membrane IEA
Inferred from Electronic Annotation
more info
 
endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular exosome HDA PubMed 
integral component of membrane IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
 
plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
metalloreductase STEAP4
Names
STEAP family member 4
seven chromosome locus associated with HCC
six transmembrane prostate protein 2
six-transmembrane epithelial antigen of prostate 4
sixTransMembrane protein of prostate 2
tumor necrosis factor, alpha-induced protein 9
tumor necrosis-alpha-induced adipose-related protein
NP_001192244.1
NP_001192245.1
NP_078912.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_028313.1 RefSeqGene

    Range
    5001..35485
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001205315.2NP_001192244.1  metalloreductase STEAP4 isoform 1

    See identical proteins and their annotated locations for NP_001192244.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an additional 5' non-coding exon, and has a longer 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AC003991, AF423422, AL833671, DB162772, DC333286
    Consensus CDS
    CCDS43611.1
    UniProtKB/Swiss-Prot
    Q687X5
    Conserved Domains (2) summary
    COG2085
    Location:21201
    COG2085; Predicted dinucleotide-binding enzyme [General function prediction only]
    pfam01794
    Location:251393
    Ferric_reduct; Ferric reductase like transmembrane component
  2. NM_001205316.2NP_001192245.1  metalloreductase STEAP4 isoform 2

    See identical proteins and their annotated locations for NP_001192245.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an in-frame coding exon compared to variant 1, resulting in a shorter isoform (2) missing an internal protein segment compared to isoform 1.
    Source sequence(s)
    AC003991, AK307644, AL833671, BC020600, DC333286
    Consensus CDS
    CCDS56494.1
    UniProtKB/Swiss-Prot
    Q687X5
    Related
    ENSP00000305545.5, ENST00000301959.9
    Conserved Domains (2) summary
    COG2085
    Location:21155
    COG2085; Predicted dinucleotide-binding enzyme [General function prediction only]
    pfam01794
    Location:163217
    Ferric_reduct; Ferric reductase like transmembrane component
  3. NM_024636.4NP_078912.2  metalloreductase STEAP4 isoform 1

    See identical proteins and their annotated locations for NP_078912.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript, and encodes the longer isoform (1). Variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AC003991, AF423422, AK307644, AL833671, DC333286
    Consensus CDS
    CCDS43611.1
    UniProtKB/Swiss-Prot
    Q687X5
    Related
    ENSP00000369419.4, ENST00000380079.8
    Conserved Domains (2) summary
    COG2085
    Location:21201
    COG2085; Predicted dinucleotide-binding enzyme [General function prediction only]
    pfam01794
    Location:251393
    Ferric_reduct; Ferric reductase like transmembrane component

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    88270892..88306894 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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