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Blood. 2006 Aug 15;108(4):1388-94. Epub 2006 Apr 11.

The Steap proteins are metalloreductases.

Author information

1
Department of Pathology, Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.

Abstract

Iron and copper are essential for all organisms, assuming critical roles as cofactors in many enzymes. In eukaryotes, the transmembrane transport of these elements is a highly regulated process facilitated by the single electron reduction of each metal. Previously, we identified a mammalian ferrireductase, Steap3, critical for erythroid iron homeostasis. Now, through homology, expression, and functional studies, we characterize all 4 members of this protein family and demonstrate that 3 of them, Steap2, Steap3, and Steap4, are not only ferrireductases but also cupric reductases that stimulate cellular uptake of both iron and copper in vitro. Finally, the pattern of tissue expression and subcellular localization of these proteins suggest they are physiologically relevant cupric reductases and ferrireductases in vivo.

PMID:
16609065
PMCID:
PMC1785011
DOI:
10.1182/blood-2006-02-003681
[Indexed for MEDLINE]
Free PMC Article

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