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LEAP2 liver enriched antimicrobial peptide 2 [ Homo sapiens (human) ]

Gene ID: 116842, updated on 1-Aug-2020

Summary

Official Symbol
LEAP2provided by HGNC
Official Full Name
liver enriched antimicrobial peptide 2provided by HGNC
Primary source
HGNC:HGNC:29571
See related
Ensembl:ENSG00000164406 MIM:611373
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LEAP-2
Summary
This gene encodes a cysteine-rich cationic antimicrobial peptide that is expressed predominantly in the liver. The mature peptide has activity against gram-positive bacteria and yeasts. [provided by RefSeq, Sep 2014]
Expression
Biased expression in liver (RPKM 158.3), small intestine (RPKM 13.5) and 1 other tissue See more
Orthologs

Genomic context

See LEAP2 in Genome Data Viewer
Location:
5q31.1
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (132873668..132875046)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (132209358..132210582)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene RNA, 5S ribosomal pseudogene 192 Neighboring gene growth differentiation factor 9 Neighboring gene ubiquinol-cytochrome c reductase complex III subunit VII Neighboring gene AF4/FMR2 family member 4 Neighboring gene eukaryotic translation elongation factor 1 alpha 2 pseudogene Neighboring gene ATPase H+ transporting V0 subunit e1 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Potential readthrough

Included gene: UQCRQ

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
antimicrobial humoral response TAS
Traceable Author Statement
more info
 
defense response to bacterium IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular region TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
liver-expressed antimicrobial peptide 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_052971.3NP_443203.1  liver-expressed antimicrobial peptide 2 precursor

    See identical proteins and their annotated locations for NP_443203.1

    Status: REVIEWED

    Source sequence(s)
    AC004500, AJ409065, BX443829
    Consensus CDS
    CCDS4163.1
    UniProtKB/Swiss-Prot
    Q969E1
    Related
    ENSP00000296877.2, ENST00000296877.3
    Conserved Domains (1) summary
    pfam07359
    Location:177
    LEAP-2; Liver-expressed antimicrobial peptide 2 precursor (LEAP-2)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    132873668..132875046
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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