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LEAP2 liver enriched antimicrobial peptide 2 [ Homo sapiens (human) ]

Gene ID: 116842, updated on 9-Dec-2024

Summary

Official Symbol
LEAP2provided by HGNC
Official Full Name
liver enriched antimicrobial peptide 2provided by HGNC
Primary source
HGNC:HGNC:29571
See related
Ensembl:ENSG00000164406 MIM:611373; AllianceGenome:HGNC:29571
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LEAP-2
Summary
This gene encodes a cysteine-rich cationic antimicrobial peptide that is expressed predominantly in the liver. The mature peptide has activity against gram-positive bacteria and yeasts. [provided by RefSeq, Sep 2014]
Expression
Biased expression in liver (RPKM 158.3), small intestine (RPKM 13.5) and 1 other tissue See more
Orthologs
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Genomic context

See LEAP2 in Genome Data Viewer
Location:
5q31.1
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (132873668..132875046)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (133393425..133394803)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (132209360..132210738)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene RNA, 5S ribosomal pseudogene 192 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr5:132201613-132202812 Neighboring gene growth differentiation factor 9 Neighboring gene ubiquinol-cytochrome c reductase complex III subunit VII Neighboring gene ALF transcription elongation factor 4 Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene 50 Neighboring gene ATPase H+ transporting V0 subunit e1 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: UQCRQ

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in extracellular region TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
liver-expressed antimicrobial peptide 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_052971.3NP_443203.1  liver-expressed antimicrobial peptide 2 precursor

    See identical proteins and their annotated locations for NP_443203.1

    Status: REVIEWED

    Source sequence(s)
    AC004500, AJ409065, BX443829
    Consensus CDS
    CCDS4163.1
    UniProtKB/Swiss-Prot
    D3DQ91, Q969E1
    UniProtKB/TrEMBL
    Q7Z5F5
    Related
    ENSP00000296877.2, ENST00000296877.3
    Conserved Domains (1) summary
    pfam07359
    Location:177
    LEAP-2; Liver-expressed antimicrobial peptide 2 precursor (LEAP-2)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    132873668..132875046
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    133393425..133394803
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)