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Leap2 liver-expressed antimicrobial peptide 2 [ Mus musculus (house mouse) ]

Gene ID: 259301, updated on 10-Jun-2024

Summary

Official Symbol
Leap2provided by MGI
Official Full Name
liver-expressed antimicrobial peptide 2provided by MGI
Primary source
MGI:MGI:2672795
See related
Ensembl:ENSMUSG00000036216 AllianceGenome:MGI:2672795
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
leap-2
Summary
Predicted to be involved in antimicrobial humoral immune response mediated by antimicrobial peptide and defense response to fungus. Predicted to act upstream of or within defense response to bacterium. Predicted to be located in extracellular region. Orthologous to human LEAP2 (liver enriched antimicrobial peptide 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in duodenum adult (RPKM 48.2), liver adult (RPKM 44.4) and 5 other tissues See more
Orthologs
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Genomic context

See Leap2 in Genome Data Viewer
Location:
11 B1.3; 11 31.94 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (53313008..53313963, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (53422181..53423136, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene AF4/FMR2 family, member 4 Neighboring gene predicted gene, 25930 Neighboring gene microRNA 6920 Neighboring gene STARR-positive B cell enhancer ABC_E76 Neighboring gene ubiquinol-cytochrome c reductase, complex III subunit VII Neighboring gene growth differentiation factor 9

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (8)  1 citation
  • Targeted (1) 

Pathways from PubChem

General protein information

Preferred Names
liver-expressed antimicrobial peptide 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153069.3NP_694709.1  liver-expressed antimicrobial peptide 2 precursor

    See identical proteins and their annotated locations for NP_694709.1

    Status: VALIDATED

    Source sequence(s)
    AA571276, W82161
    Consensus CDS
    CCDS36150.1
    UniProtKB/Swiss-Prot
    Q5EBH6, Q91V13
    Related
    ENSMUSP00000044166.6, ENSMUST00000036045.6
    Conserved Domains (1) summary
    pfam07359
    Location:176
    LEAP-2; Liver-expressed antimicrobial peptide 2 precursor (LEAP-2)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    53313008..53313963 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)