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UQCRQ ubiquinol-cytochrome c reductase complex III subunit VII [ Homo sapiens (human) ]

Gene ID: 27089, updated on 1-Jun-2020

Summary

Official Symbol
UQCRQprovided by HGNC
Official Full Name
ubiquinol-cytochrome c reductase complex III subunit VIIprovided by HGNC
Primary source
HGNC:HGNC:29594
See related
Ensembl:ENSG00000164405 MIM:612080
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
QPC; QCR8; QP-C; UQCR7; MC3DN4
Summary
This gene encodes a ubiquinone-binding protein of low molecular mass. This protein is a small core-associated protein and a subunit of ubiquinol-cytochrome c reductase complex III, which is part of the mitochondrial respiratory chain. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in heart (RPKM 47.2), colon (RPKM 46.6) and 25 other tissues See more
Orthologs

Genomic context

See UQCRQ in Genome Data Viewer
Location:
5q31.1
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (132866642..132868847)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (132202319..132204536)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene RNA, U7 small nuclear 15 pseudogene Neighboring gene RNA, 5S ribosomal pseudogene 192 Neighboring gene growth differentiation factor 9 Neighboring gene liver enriched antimicrobial peptide 2 Neighboring gene AF4/FMR2 family member 4 Neighboring gene eukaryotic translation elongation factor 1 alpha 2 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: LEAP2

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to ubiquinol-cytochrome-c reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
cerebellar Purkinje cell layer development IEA
Inferred from Electronic Annotation
more info
 
hippocampus development IEA
Inferred from Electronic Annotation
more info
 
hypothalamus development IEA
Inferred from Electronic Annotation
more info
 
midbrain development IEA
Inferred from Electronic Annotation
more info
 
mitochondrial electron transport, ubiquinol to cytochrome c IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial electron transport, ubiquinol to cytochrome c TAS
Traceable Author Statement
more info
 
pons development IEA
Inferred from Electronic Annotation
more info
 
pyramidal neuron development IEA
Inferred from Electronic Annotation
more info
 
subthalamus development IEA
Inferred from Electronic Annotation
more info
 
thalamus development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrial inner membrane TAS
Traceable Author Statement
more info
 
mitochondrial respiratory chain complex III IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
cytochrome b-c1 complex subunit 8
Names
complex III subunit 8
complex III subunit VIII
low molecular mass ubiquinone-binding protein (9.5kD)
ubiquinol-cytochrome c reductase complex 9.5 kDa protein
ubiquinol-cytochrome c reductase complex ubiquinone-binding protein QP-C
ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa
NP_055217.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012221.1 RefSeqGene

    Range
    5016..7221
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_014402.5NP_055217.2  cytochrome b-c1 complex subunit 8

    See identical proteins and their annotated locations for NP_055217.2

    Status: REVIEWED

    Source sequence(s)
    AC004500, BU190580, BU953465, CR743513
    Consensus CDS
    CCDS34237.1
    UniProtKB/Swiss-Prot
    O14949
    Related
    ENSP00000367939.3, ENST00000378670.8
    Conserved Domains (1) summary
    pfam02939
    Location:479
    UcrQ; UcrQ family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    132866642..132868847
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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