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ZNF837 zinc finger protein 837 [ Homo sapiens (human) ]

Gene ID: 116412, updated on 23-Nov-2021

Summary

Official Symbol
ZNF837provided by HGNC
Official Full Name
zinc finger protein 837provided by HGNC
Primary source
HGNC:HGNC:25164
See related
Ensembl:ENSG00000152475
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See ZNF837 in Genome Data Viewer
Location:
19q13.43
Exon count:
3
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (58367623..58381030, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (58878990..58892397, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 497 Neighboring gene zinc finger protein 446 pseudogene Neighboring gene ZNF497 antisense RNA 1 Neighboring gene RNA, 5S ribosomal pseudogene 473 Neighboring gene uncharacterized LOC105372484 Neighboring gene Sharpr-MPRA regulatory region 7872 Neighboring gene microRNA 4754 Neighboring gene ribosomal protein S5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138466.2NP_612475.1  zinc finger protein 837

    See identical proteins and their annotated locations for NP_612475.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site, compared to variant 1, and is protein-coding.
    Source sequence(s)
    AC012313, BC012365, BX374687
    Consensus CDS
    CCDS46216.1
    UniProtKB/Swiss-Prot
    Q96EG3
    Related
    ENSP00000471478.1, ENST00000597582.2
    Conserved Domains (3) summary
    COG5048
    Location:361521
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:449469
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl26386
    Location:3265
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III

RNA

  1. NR_049780.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC012313, BC012365, BC029960, BX332043

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    58367623..58381030 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017026242.1XP_016881731.1  zinc finger protein 837 isoform X1

    UniProtKB/Swiss-Prot
    Q96EG3
    Conserved Domains (3) summary
    COG5048
    Location:361521
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:449469
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl26386
    Location:3265
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001129730.1: Suppressed sequence

    Description
    NM_001129730.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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