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RBP7 retinol binding protein 7 [ Homo sapiens (human) ]

Gene ID: 116362, updated on 7-Jun-2020

Summary

Official Symbol
RBP7provided by HGNC
Official Full Name
retinol binding protein 7provided by HGNC
Primary source
HGNC:HGNC:30316
See related
Ensembl:ENSG00000162444 MIM:608604
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CRBP4; CRABP4; CRBPIV
Summary
The protein encoded by this gene is a member of the cellular retinol-binding protein (CRBP) family, whose members are required for vitamin A stability and metabolism. The encoded protein binds all-trans-retinol and is structurally similar to other CRBPs; however, it has a lower binding affinity for retinol than other CRBPs. [provided by RefSeq, Aug 2016]
Expression
Biased expression in fat (RPKM 138.2), spleen (RPKM 25.4) and 7 other tissues See more
Orthologs

Genomic context

See RBP7 in Genome Data Viewer
Location:
1p36.22
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (9997228..10016021)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (10057255..10076078)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene nicotinamide nucleotide adenylyltransferase 1 Neighboring gene transmembrane protein 274, pseudogene Neighboring gene microRNA 5697 Neighboring gene ubiquitination factor E4B Neighboring gene ribosomal protein L21 pseudogene 21 Neighboring gene phosphoglycerate mutase 1 pseudogene 11

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC70641

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
retinal binding IEA
Inferred from Electronic Annotation
more info
 
retinol binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
retinoid-binding protein 7
Names
cellular retinoic acid-binding protein 4
cellular retinoic acid-binding protein IV
cellular retinol binding protein 7
putative cellular retinol-binding protein CRBP IV
retinol binding protein 7, cellular
NP_443192.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_052960.3NP_443192.1  retinoid-binding protein 7

    See identical proteins and their annotated locations for NP_443192.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the protein-coding transcript.
    Source sequence(s)
    AL590639, BC063013
    Consensus CDS
    CCDS109.1
    UniProtKB/Swiss-Prot
    Q96R05
    Related
    ENSP00000294435.7, ENST00000294435.8
    Conserved Domains (1) summary
    pfam00061
    Location:6134
    Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

RNA

  1. NR_138250.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL590639, BC033883
    Related
    ENST00000315901.4

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    9997228..10016021
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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