Rbp7 retinol binding protein 7, cellular [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rbp7provided by MGI
Official Full Name: retinol binding protein 7, cellularprovided by MGI
Primary source: MGI:MGI:1890409
See related: Ensembl:ENSMUSG00000028996 AllianceGenome:MGI:1890409
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CRBP-III; 1110002J23Rik
Summary: Enables retinoid binding activity. Predicted to be involved in fatty acid transport. Predicted to be located in cytoplasm. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including dorsal aorta; epididymal fat pad; musculature; respiratory system; and somite. Orthologous to human RBP7 (retinol binding protein 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in subcutaneous fat pad adult (RPKM 3.4), heart adult (RPKM 2.0) and 13 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4; 4 E2

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (149534144..149550919, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (149449687..149466462, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

conclude that RBP7 is required to mediate the protective effects of PPARgamma in the endothelium through adiponectin, and RBP7 is an endothelium-specific PPARgamma target and regulator of PPARgamma activity
Title: Retinol-binding protein 7 is an endothelium-specific PPARγ cofactor mediating an antioxidant response through adiponectin.
Data showed that the mouse Rbp7 gene produces a predominant isoform in adipose tissue during adipocyte development, cold exposure, and nutritional treatments.
Title: Adipose-specific expression of mouse Rbp7 gene and its developmental and metabolic changes.
The results provide evidence for an exclusive proteasome subunit-related mechanism for transcriptional activation of RBP4 within a GLUT4 knockdown model.
Title: Identification of glucose transporter 4 knockdown-dependent transcriptional activation element on the retinol binding protein 4 gene promoter and requirement of the 20 S proteasome subunit for transcriptional activity.
CRBP-III is a PPARgamma target gene and plays a role in lipid and whole body energy metabolism.
Title: Cellular retinol-binding protein type III is a PPARgamma target gene and plays a role in lipid metabolism.
demonstrated that retinol bound to CRBP-III is an excellent substrate for lecithin-retinol acyltransferase, the enzyme responsible for catalyzing retinyl ester formation from retinol
Title: Cellular retinol-binding protein type III is needed for retinoid incorporation into milk.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (1)

General gene information

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Markers

Rbp7 (e-PCR), detects polymorphism
- UniSTS:526960

Homology

Homologs of the Rbp7 gene: The Rbp7 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, and zebrafish.
Orthologs from Annotation Pipeline: 314 organisms have orthologs with human gene Rbp7
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables fatty acid binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables retinal binding	IEA Inferred from Electronic Annotation more info
enables retinoid binding	IDA Inferred from Direct Assay more info	PubMed
enables retinol binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in fatty acid transport	IBA Inferred from Biological aspect of Ancestor more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info	PubMed

General protein information

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Preferred Names: retinoid-binding protein 7

Names: CRABP-IV; CRABP4; CRBP4; cellular retinoic acid-binding protein 4; cellular retinoic acid-binding protein IV; cellular retinol binding protein type III; cytosolic binding protein

NP_071303.1

EC 2.7.7.1

XP_006539148.1

EC 2.7.7.1

XP_006539150.1

EC 2.7.7.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.