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ADCYAP1 adenylate cyclase activating polypeptide 1 [ Homo sapiens (human) ]

Gene ID: 116, updated on 7-Dec-2018

Summary

Official Symbol
ADCYAP1provided by HGNC
Official Full Name
adenylate cyclase activating polypeptide 1provided by HGNC
Primary source
HGNC:HGNC:241
See related
Ensembl:ENSG00000141433 MIM:102980
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PACAP
Summary
This gene encodes a secreted proprotein that is further processed into multiple mature peptides. These peptides stimulate adenylate cyclase and increase cyclic adenosine monophosphate (cAMP) levels, resulting in the transcriptional activation of target genes. The products of this gene are key mediators of neuroendocrine stress responses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2013]
Expression
Biased expression in appendix (RPKM 6.6), brain (RPKM 5.7) and 11 other tissues See more
Orthologs

Genomic context

See ADCYAP1 in Genome Data Viewer
Location:
18p11.32
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 18 NC_000018.10 (904384..912172)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (904366..912173)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene bolA family member 2 pseudogene 1 Neighboring gene proteasome 26S subunit, non-ATPase 8 pseudogene Neighboring gene long intergenic non-protein coding RNA 1904 Neighboring gene uncharacterized LOC107985165

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genetic Loci Associated with Circulating Levels of Very Long-Chain Saturated Fatty Acids.
NHGRI GWA Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat PACAP27-induced release of CCL5 inhibits HIV-1 Tat-mediated toxicity in human astrocytes PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Activation of TRKA receptors, organism-specific biosystem (from REACTOME)
    Activation of TRKA receptors, organism-specific biosystemTrk receptors can either be activated by neurotrophins or by two G-protein-coupled receptors (GPCRs) although the biological relevance of GPCRs remains to be shown.
  • Class B/2 (Secretin family receptors), organism-specific biosystem (from REACTOME)
    Class B/2 (Secretin family receptors), organism-specific biosystemThis family is known as Family B (secretin-receptor family, family 2) G-protein-coupled receptors. Family B GPCRs include secretin, calcitonin, parathyroid hormone/parathyroid hormone-related peptide...
  • G alpha (s) signalling events, organism-specific biosystem (from REACTOME)
    G alpha (s) signalling events, organism-specific biosystemThe general function of the G alpha (s) subunit (Gs) is to activate adenylate cyclase, which in turn produces cAMP, leading to the activation of cAMP-dependent protein kinases (often referred to col...
  • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
    GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
  • GPCR ligand binding, organism-specific biosystem (from REACTOME)
    GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
  • Glucagon-type ligand receptors, organism-specific biosystem (from REACTOME)
    Glucagon-type ligand receptors, organism-specific biosystemThe glucagon hormone family regulates the activity of GPCRs from the secretin receptor subfamily in Class II/B (Mayo KE et al, 2003).
  • Insulin secretion, organism-specific biosystem (from KEGG)
    Insulin secretion, organism-specific biosystemPancreatic beta cells are specialised endocrine cells that continuously sense the levels of blood sugar and other fuels and, in response, secrete insulin to maintain normal fuel homeostasis. Glucose-...
  • NGF signalling via TRKA from the plasma membrane, organism-specific biosystem (from REACTOME)
    NGF signalling via TRKA from the plasma membrane, organism-specific biosystemTrk receptors signal from the plasma membrane and from intracellular membranes, particularly from early endosomes. Signalling from the plasma membrane is fast but transient; signalling from endosomes...
  • NGF-independant TRKA activation, organism-specific biosystem (from REACTOME)
    NGF-independant TRKA activation, organism-specific biosystemTRK receptors can also be activated by at least two G-protein-coupled receptors (GPCR), the adenosine A2a receptor and the PACAP type I receptor, without involvement of neurotrophins. Activity of bo...
  • Renin secretion, organism-specific biosystem (from KEGG)
    Renin secretion, organism-specific biosystemThe aspartyl-protease renin is the key regulator of the renin-angiotensin-aldosterone system, which is critically involved in extracellular fluid volume and blood pressure homeostasis of the body. R...
  • Renin secretion, conserved biosystem (from KEGG)
    Renin secretion, conserved biosystemThe aspartyl-protease renin is the key regulator of the renin-angiotensin-aldosterone system, which is critically involved in extracellular fluid volume and blood pressure homeostasis of the body. R...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by GPCR, organism-specific biosystem (from REACTOME)
    Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
  • Signalling by NGF, organism-specific biosystem (from REACTOME)
    Signalling by NGF, organism-specific biosystemNeurotrophins (NGF, BDNF, NT-3, NT-4/5) play pivotal roles in survival, differentiation, and plasticity of neurons in the peripheral and central nervous system. They are produced, and secreted in mi...
  • Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways, organism-specific biosystem (from WikiPathways)
    Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways, organism-specific biosystemIn this model, we provide an integrated view of Sudden Infant Death Syndrome (SIDS) at the level of implicated tissues, signaling networks and genetics. The purpose of this model is to serve as an ov...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC126852

Gene Ontology Provided by GOA

Function Evidence Code Pubs
neuropeptide hormone activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuropeptide hormone activity IDA
Inferred from Direct Assay
more info
PubMed 
peptide hormone receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptide hormone receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
peptide hormone receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
pituitary adenylate cyclase activating polypeptide activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
pituitary adenylate cyclase activating polypeptide activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
signaling receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
activation of adenylate cyclase activity TAS
Traceable Author Statement
more info
PubMed 
adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
cAMP-mediated signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell-cell signaling TAS
Traceable Author Statement
more info
PubMed 
female pregnancy TAS
Traceable Author Statement
more info
PubMed 
insulin secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
neuron projection development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuron projection development IDA
Inferred from Direct Assay
more info
PubMed 
neuropeptide signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuropeptide signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of ERK1 and ERK2 cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of chemokine (C-C motif) ligand 5 production IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of cytosolic calcium ion concentration ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of growth hormone secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
regulation of G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
regulation of protein localization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of protein localization IDA
Inferred from Direct Assay
more info
PubMed 
regulation of signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular region TAS
Traceable Author Statement
more info
 
neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
perikaryon IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
pituitary adenylate cyclase-activating polypeptide
Names
adenylate cyclase activating polypeptide 1 (pituitary)
prepro-PACAP

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001099733.2NP_001093203.1  pituitary adenylate cyclase-activating polypeptide preproprotein

    See identical proteins and their annotated locations for NP_001093203.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AP000894, BC093837, DC320719
    Consensus CDS
    CCDS11825.1
    UniProtKB/Swiss-Prot
    P18509
    Related
    ENSP00000411658.3, ENST00000450565.7
    Conserved Domains (2) summary
    smart00070
    Location:83109
    GLUCA; Glucagon like hormones
    pfam00123
    Location:132158
    Hormone_2; Peptide hormone
  2. NM_001117.4NP_001108.2  pituitary adenylate cyclase-activating polypeptide preproprotein

    See identical proteins and their annotated locations for NP_001108.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AP000894, BC093837, DA145895
    Consensus CDS
    CCDS11825.1
    UniProtKB/Swiss-Prot
    P18509
    Related
    ENSP00000462647.1, ENST00000579794.1
    Conserved Domains (2) summary
    smart00070
    Location:83109
    GLUCA; Glucagon like hormones
    pfam00123
    Location:132158
    Hormone_2; Peptide hormone

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p12 Primary Assembly

    Range
    904384..912172
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005258081.4XP_005258138.2  pituitary adenylate cyclase-activating polypeptide isoform X1

    Conserved Domains (2) summary
    smart00070
    Location:222248
    GLUCA; Glucagon like hormones
    pfam00123
    Location:271297
    Hormone_2; Peptide hormone
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