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ADCYAP1 adenylate cyclase activating polypeptide 1 [ Homo sapiens (human) ]

Gene ID: 116, updated on 9-Jan-2024

Summary

Official Symbol
ADCYAP1provided by HGNC
Official Full Name
adenylate cyclase activating polypeptide 1provided by HGNC
Primary source
HGNC:HGNC:241
See related
Ensembl:ENSG00000141433 MIM:102980; AllianceGenome:HGNC:241
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PACAP
Summary
This gene encodes a secreted proprotein that is further processed into multiple mature peptides. These peptides stimulate adenylate cyclase and increase cyclic adenosine monophosphate (cAMP) levels, resulting in the transcriptional activation of target genes. The products of this gene are key mediators of neuroendocrine stress responses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2013]
Expression
Biased expression in appendix (RPKM 6.6), brain (RPKM 5.7) and 11 other tissues See more
Orthologs
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Genomic context

See ADCYAP1 in Genome Data Viewer
Location:
18p11.32
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (904411..912172)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (1058628..1066467)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (904872..912173)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene bolA family member 2 pseudogene 1 Neighboring gene proteasome 26S subunit, non-ATPase 8 pseudogene Neighboring gene MPRA-validated peak3036 silencer Neighboring gene uncharacterized LOC124904340 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:907717-908438 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:909161-909882 Neighboring gene long intergenic non-protein coding RNA 1904 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:949337-949911 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:949912-950485 Neighboring gene uncharacterized LOC107985165 Neighboring gene Sharpr-MPRA regulatory region 14540 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr18:1011056-1012255 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr18:1015112-1015673

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genetic Loci Associated with Circulating Levels of Very Long-Chain Saturated Fatty Acids.
EBI GWAS Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat PACAP27-induced release of CCL5 inhibits HIV-1 Tat-mediated toxicity in human astrocytes PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC126852

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables neuropeptide hormone activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables neuropeptide hormone activity IDA
Inferred from Direct Assay
more info
PubMed 
enables peptide hormone receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables peptide hormone receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
enables peptide hormone receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables pituitary adenylate cyclase activating polypeptide activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables pituitary adenylate cyclase activating polypeptide activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor binding IPI
Inferred from Physical Interaction
more info
 
Process Evidence Code Pubs
involved_in activation of adenylate cyclase activity TAS
Traceable Author Statement
more info
PubMed 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cAMP-mediated signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell-cell signaling TAS
Traceable Author Statement
more info
PubMed 
involved_in female pregnancy TAS
Traceable Author Statement
more info
PubMed 
involved_in insulin secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in neuron projection development IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in neuron projection development IDA
Inferred from Direct Assay
more info
PubMed 
involved_in neuropeptide signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in neuropeptide signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of chemokine (C-C motif) ligand 5 production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in positive regulation of cytosolic calcium ion concentration ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of growth hormone secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of protein localization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of protein localization IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in extracellular region TAS
Traceable Author Statement
more info
 
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in perikaryon IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
pituitary adenylate cyclase-activating polypeptide
Names
adenylate cyclase activating polypeptide 1 (pituitary)
prepro-PACAP

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001099733.2NP_001093203.1  pituitary adenylate cyclase-activating polypeptide preproprotein

    See identical proteins and their annotated locations for NP_001093203.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AP000894, BC093837, DC320719
    Consensus CDS
    CCDS11825.1
    UniProtKB/Swiss-Prot
    B2R7N4, P18509, Q52LQ0
    Related
    ENSP00000411658.3, ENST00000450565.8
    Conserved Domains (2) summary
    smart00070
    Location:83109
    GLUCA; Glucagon like hormones
    pfam00123
    Location:132158
    Hormone_2; Peptide hormone
  2. NM_001117.5NP_001108.2  pituitary adenylate cyclase-activating polypeptide preproprotein

    See identical proteins and their annotated locations for NP_001108.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AP000894, BC093837
    Consensus CDS
    CCDS11825.1
    UniProtKB/Swiss-Prot
    B2R7N4, P18509, Q52LQ0
    Related
    ENSP00000462647.1, ENST00000579794.1
    Conserved Domains (2) summary
    smart00070
    Location:83109
    GLUCA; Glucagon like hormones
    pfam00123
    Location:132158
    Hormone_2; Peptide hormone

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

    Range
    904411..912172
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005258081.5XP_005258138.2  pituitary adenylate cyclase-activating polypeptide isoform X2

    UniProtKB/TrEMBL
    B7Z222
    Conserved Domains (2) summary
    smart00070
    Location:222248
    GLUCA; Glucagon like hormones
    pfam00123
    Location:271297
    Hormone_2; Peptide hormone
  2. XM_047437288.1XP_047293244.1  pituitary adenylate cyclase-activating polypeptide isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060942.1 Alternate T2T-CHM13v2.0

    Range
    1058628..1066467
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054318174.1XP_054174149.1  pituitary adenylate cyclase-activating polypeptide isoform X3

  2. XM_054318173.1XP_054174148.1  pituitary adenylate cyclase-activating polypeptide isoform X1