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Adcyap1 adenylate cyclase activating polypeptide 1 [ Mus musculus (house mouse) ]

Gene ID: 11516, updated on 8-Feb-2024

Summary

Official Symbol
Adcyap1provided by MGI
Official Full Name
adenylate cyclase activating polypeptide 1provided by MGI
Primary source
MGI:MGI:105094
See related
Ensembl:ENSMUSG00000024256 AllianceGenome:MGI:105094
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PACAP
Summary
This gene encodes a member of the glucagon superfamily of hormones that have important roles in growth and metabolism. The encoded protein undergoes proteolytic processing to generate mature peptides that function as hypophysiotropic hormones, neurotransmitters, neuromodulators and vasoregulators. Mice lacking the encoded protein exhibit a high rate of early mortality. The surviving adult animals lacking the encoded protein exhibit decreased anxiety, hyperactive behavior and impaired steroidogenesis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2015]
Expression
Biased expression in CNS E18 (RPKM 2.0), CNS E14 (RPKM 1.8) and 6 other tissues See more
Orthologs
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Genomic context

See Adcyap1 in Genome Data Viewer
Location:
17 E5; 17 60.67 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (93506448..93513967)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (93198245..93206541)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53959 Neighboring gene STARR-seq mESC enhancer starr_43615 Neighboring gene STARR-seq mESC enhancer starr_43616 Neighboring gene pyruvate kinase, muscle pseudogene Neighboring gene STARR-seq mESC enhancer starr_43617 Neighboring gene STARR-seq mESC enhancer starr_43618 Neighboring gene STARR-seq mESC enhancer starr_43619 Neighboring gene STARR-seq mESC enhancer starr_43620 Neighboring gene STARR-seq mESC enhancer starr_43621 Neighboring gene predicted gene, 32465 Neighboring gene predicted gene, 25935 Neighboring gene ribosomal protein L3 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (8)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hormone activity IEA
Inferred from Electronic Annotation
more info
 
enables neuropeptide hormone activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables neuropeptide hormone activity ISO
Inferred from Sequence Orthology
more info
 
enables neuropeptide hormone activity TAS
Traceable Author Statement
more info
PubMed 
enables peptide hormone receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables peptide hormone receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables pituitary adenylate cyclase activating polypeptide activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables pituitary adenylate cyclase activating polypeptide activity IDA
Inferred from Direct Assay
more info
PubMed 
enables pituitary adenylate cyclase activating polypeptide activity ISO
Inferred from Sequence Orthology
more info
 
enables pituitary adenylate cyclase-activating polypeptide receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within activation of adenylate cyclase activity TAS
Traceable Author Statement
more info
PubMed 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in behavioral fear response ISO
Inferred from Sequence Orthology
more info
 
involved_in cAMP-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in histamine secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in insulin secretion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of acute inflammatory response to antigenic stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of acute inflammatory response to non-antigenic stimulus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of glial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of muscle cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of potassium ion transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within nervous system development IEA
Inferred from Electronic Annotation
more info
 
involved_in neuron projection development IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in neuron projection development ISO
Inferred from Sequence Orthology
more info
 
involved_in neuropeptide signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in neuropeptide signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neuropeptide signaling pathway TAS
Traceable Author Statement
more info
PubMed 
involved_in ovarian follicle development ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of ERK1 and ERK2 cascade IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of GTPase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cAMP-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of chemokine (C-C motif) ligand 5 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cold-induced thermogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of growth hormone secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-6 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of somatostatin secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of synaptic transmission, glutamatergic ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of oligodendrocyte progenitor proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of postsynaptic membrane potential ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of protein localization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of protein localization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of protein localization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in vasodilation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in perikaryon IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in terminal bouton ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
pituitary adenylate cyclase-activating polypeptide

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001315503.2NP_001302432.1  pituitary adenylate cyclase-activating polypeptide isoform 1 preproprotein

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein (isoform 1).
    Source sequence(s)
    AC154798
    Consensus CDS
    CCDS29029.1
    UniProtKB/Swiss-Prot
    O70176
    UniProtKB/TrEMBL
    Q3UYH8, Q8BJT8
    Related
    ENSMUSP00000157279.2, ENSMUST00000234081.2
    Conserved Domains (1) summary
    pfam00123
    Location:131158
    Hormone_2; Peptide hormone
  2. NM_001315504.2NP_001302433.1  pituitary adenylate cyclase-activating polypeptide isoform 2 preproprotein

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 3' terminal exon, compared to variant 1. It encodes isoform 2, which is longer and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC154798
    UniProtKB/TrEMBL
    Q8BJT8
    Conserved Domains (1) summary
    pfam00123
    Location:131157
    Hormone_2; Peptide hormone
  3. NM_001409525.1NP_001396454.1  pituitary adenylate cyclase-activating polypeptide isoform 3 preproprotein

    Status: VALIDATED

    Source sequence(s)
    AC154798
    UniProtKB/TrEMBL
    Q8BJT8
  4. NM_001409527.1NP_001396456.1  pituitary adenylate cyclase-activating polypeptide isoform 3 preproprotein

    Status: VALIDATED

    Source sequence(s)
    AC154798
    UniProtKB/TrEMBL
    Q8BJT8
  5. NM_001409528.1NP_001396457.1  pituitary adenylate cyclase-activating polypeptide isoform 1 preproprotein

    Status: VALIDATED

    Source sequence(s)
    AC154798
    UniProtKB/Swiss-Prot
    O70176
    UniProtKB/TrEMBL
    Q3UYH8, Q8BJT8
  6. NM_001409530.1NP_001396459.1  pituitary adenylate cyclase-activating polypeptide isoform 1 preproprotein

    Status: VALIDATED

    Source sequence(s)
    AC154798
    UniProtKB/Swiss-Prot
    O70176
    UniProtKB/TrEMBL
    Q3UYH8, Q8BJT8
  7. NM_001409531.1NP_001396460.1  pituitary adenylate cyclase-activating polypeptide isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC154798
  8. NM_001409532.1NP_001396461.1  pituitary adenylate cyclase-activating polypeptide isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC154798
  9. NM_001412216.1NP_001399145.1  pituitary adenylate cyclase-activating polypeptide isoform 2 preproprotein

    Status: VALIDATED

    Source sequence(s)
    AC154798
    UniProtKB/TrEMBL
    Q8BJT8
  10. NM_009625.4NP_033755.1  pituitary adenylate cyclase-activating polypeptide isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_033755.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Both variants 1 and 2 encode the same protein (isoform 1).
    Source sequence(s)
    AC154798
    Consensus CDS
    CCDS29029.1
    UniProtKB/Swiss-Prot
    O70176
    UniProtKB/TrEMBL
    Q3UYH8, Q8BJT8
    Related
    ENSMUSP00000067057.7, ENSMUST00000064775.8
    Conserved Domains (1) summary
    pfam00123
    Location:131158
    Hormone_2; Peptide hormone

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    93506448..93513967
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)