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WDFY2 WD repeat and FYVE domain containing 2 [ Homo sapiens (human) ]

Gene ID: 115825, updated on 7-Jun-2020

Summary

Official Symbol
WDFY2provided by HGNC
Official Full Name
WD repeat and FYVE domain containing 2provided by HGNC
Primary source
HGNC:HGNC:20482
See related
Ensembl:ENSG00000139668 MIM:610418
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PROF; WDF2; ZFYVE22
Summary
This gene encodes a protein that contains two WD domains and an FYVE zinc finger region. The function of this gene is unknown. An alternatively spliced transcript variant of this gene may exist. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in skin (RPKM 5.8), bone marrow (RPKM 4.0) and 25 other tissues See more
Orthologs

Genomic context

See WDFY2 in Genome Data Viewer
Location:
13q14.3
Exon count:
15
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 13 NC_000013.11 (51584194..51767709)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (52158484..52340935)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene microRNA 4703 Neighboring gene RNA, U6 small nuclear 65, pseudogene Neighboring gene RNA, 7SL, cytoplasmic 413, pseudogene Neighboring gene RNY1 pseudogene 6 Neighboring gene ATP synthase peripheral stalk-membrane subunit b pseudogene 1 Neighboring gene dehydrogenase/reductase 12 Neighboring gene uncharacterized LOC107984561 Neighboring gene transmembrane protein 272

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
positive regulation of fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
early endosome IDA
Inferred from Direct Assay
more info
PubMed 
vesicle IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
WD repeat and FYVE domain-containing protein 2
Names
WD40 and FYVE domain containing 2
WD40- and FYVE domain-containing protein 2
propeller-FYVE protein
zinc finger FYVE domain-containing protein 22

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_052950.4NP_443182.1  WD repeat and FYVE domain-containing protein 2

    See identical proteins and their annotated locations for NP_443182.1

    Status: REVIEWED

    Source sequence(s)
    AL136525, BC014004, DA124107
    Consensus CDS
    CCDS9429.1
    UniProtKB/Swiss-Prot
    Q96P53
    Related
    ENSP00000298125.4, ENST00000298125.7
    Conserved Domains (3) summary
    cd15718
    Location:279348
    FYVE_WDFY1_like; FYVE domain found in WD40 repeat and FYVE domain-containing protein WDFY1 and WDFY2, and similar proteins
    sd00039
    Location:159197
    7WD40; WD40 repeat [structural motif]
    cl25539
    Location:16272
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p13 Primary Assembly

    Range
    51584194..51767709
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024449316.1XP_024305084.1  WD repeat and FYVE domain-containing protein 2 isoform X2

    Conserved Domains (4) summary
    smart00320
    Location:292328
    WD40; WD40 repeats
    cd15718
    Location:213282
    FYVE_WDFY1_like; FYVE domain found in WD40 repeat and FYVE domain-containing protein WDFY1 and WDFY2, and similar proteins
    sd00039
    Location:93131
    7WD40; WD40 repeat [structural motif]
    cl25539
    Location:2210
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. XM_017020386.1XP_016875875.1  WD repeat and FYVE domain-containing protein 2 isoform X3

    Conserved Domains (5) summary
    smart00320
    Location:269305
    WD40; WD40 repeats
    COG2319
    Location:13305
    WD40; WD40 repeat [General function prediction only]
    cd15718
    Location:190259
    FYVE_WDFY1_like; FYVE domain found in WD40 repeat and FYVE domain-containing protein WDFY1 and WDFY2, and similar proteins
    sd00039
    Location:70108
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:11183
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  3. XM_011534915.2XP_011533217.1  WD repeat and FYVE domain-containing protein 2 isoform X3

    See identical proteins and their annotated locations for XP_011533217.1

    Conserved Domains (5) summary
    smart00320
    Location:269305
    WD40; WD40 repeats
    COG2319
    Location:13305
    WD40; WD40 repeat [General function prediction only]
    cd15718
    Location:190259
    FYVE_WDFY1_like; FYVE domain found in WD40 repeat and FYVE domain-containing protein WDFY1 and WDFY2, and similar proteins
    sd00039
    Location:70108
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:11183
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  4. XM_011534914.1XP_011533216.1  WD repeat and FYVE domain-containing protein 2 isoform X1

    Conserved Domains (4) summary
    COG2319
    Location:18272
    WD40; WD40 repeat [General function prediction only]
    cd15718
    Location:279348
    FYVE_WDFY1_like; FYVE domain found in WD40 repeat and FYVE domain-containing protein WDFY1 and WDFY2, and similar proteins
    sd00039
    Location:202239
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:16272
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  5. XM_024449317.1XP_024305085.1  WD repeat and FYVE domain-containing protein 2 isoform X2

    Conserved Domains (4) summary
    smart00320
    Location:292328
    WD40; WD40 repeats
    cd15718
    Location:213282
    FYVE_WDFY1_like; FYVE domain found in WD40 repeat and FYVE domain-containing protein WDFY1 and WDFY2, and similar proteins
    sd00039
    Location:93131
    7WD40; WD40 repeat [structural motif]
    cl25539
    Location:2210
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RNA

  1. XR_941484.2 RNA Sequence

  2. XR_941485.2 RNA Sequence

  3. XR_941483.1 RNA Sequence

  4. XR_001749475.1 RNA Sequence

  5. XR_941489.1 RNA Sequence

  6. XR_941487.1 RNA Sequence

  7. XR_941488.1 RNA Sequence

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