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WDFY2 WD repeat and FYVE domain containing 2 [ Homo sapiens (human) ]

Gene ID: 115825, updated on 3-May-2025
Official Symbol
WDFY2provided by HGNC
Official Full Name
WD repeat and FYVE domain containing 2provided by HGNC
Primary source
HGNC:HGNC:20482
See related
Ensembl:ENSG00000139668 MIM:610418; AllianceGenome:HGNC:20482
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PROF; WDF2; ZFYVE22
Summary
This gene encodes a protein that contains two WD domains and an FYVE zinc finger region. The function of this gene is unknown. An alternatively spliced transcript variant of this gene may exist. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in skin (RPKM 5.8), bone marrow (RPKM 4.0) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table
See WDFY2 in Genome Data Viewer
Location:
13q14.3
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (51584462..51767709)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (50799394..50982622)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (52158598..52341845)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene microRNA 4703 Neighboring gene OCT4-H3K27ac hESC enhancer GRCh37_chr13:52157850-52158370 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5375 Neighboring gene RNA, U6 small nuclear 65, pseudogene Neighboring gene RNA, 7SL, cytoplasmic 413, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7776 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7777 Neighboring gene RNY1 pseudogene 6 Neighboring gene ATP synthase peripheral stalk-membrane subunit b pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:52200616-52201123 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:52201124-52201630 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:52201812-52202431 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:52202432-52203050 Neighboring gene H3K27ac hESC enhancer GRCh37_chr13:52216947-52217446 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:52220347-52220993 Neighboring gene Sharpr-MPRA regulatory region 2859 Neighboring gene uncharacterized LOC124903177 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7778 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_32930 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5376 Neighboring gene dehydrogenase/reductase 12 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7779 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:52371189-52371717 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7780 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7781 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5377 Neighboring gene uncharacterized LOC107984561 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7782 Neighboring gene transmembrane protein 272 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:52423314-52423814 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr13:52435707-52436906 Neighboring gene coiled-coil domain containing 70

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
Products Interactant Other Gene Complex Source Pubs Description

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in early endosome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in early endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in early endosome IEA
Inferred from Electronic Annotation
more info
 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
located_in vesicle IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
WD repeat and FYVE domain-containing protein 2
Names
WD40 and FYVE domain containing 2
WD40- and FYVE domain-containing protein 2
propeller-FYVE protein
zinc finger FYVE domain-containing protein 22

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_052950.4NP_443182.1  WD repeat and FYVE domain-containing protein 2

    See identical proteins and their annotated locations for NP_443182.1

    Status: REVIEWED

    Source sequence(s)
    AL136525, BC014004, DA124107
    Consensus CDS
    CCDS9429.1
    UniProtKB/Swiss-Prot
    B1AL86, Q96CS1, Q96P53
    Related
    ENSP00000298125.4, ENST00000298125.7
    Conserved Domains (3) summary
    cd15718
    Location:279348
    FYVE_WDFY1_like; FYVE domain found in WD40 repeat and FYVE domain-containing protein WDFY1 and WDFY2, and similar proteins
    sd00039
    Location:159197
    7WD40; WD40 repeat [structural motif]
    cl25539
    Location:16272
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

    Range
    51584462..51767709
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011534915.3XP_011533217.1  WD repeat and FYVE domain-containing protein 2 isoform X3

    See identical proteins and their annotated locations for XP_011533217.1

    UniProtKB/TrEMBL
    Q96LK4
    Conserved Domains (5) summary
    smart00320
    Location:269305
    WD40; WD40 repeats
    COG2319
    Location:13305
    WD40; WD40 repeat [General function prediction only]
    cd15718
    Location:190259
    FYVE_WDFY1_like; FYVE domain found in WD40 repeat and FYVE domain-containing protein WDFY1 and WDFY2, and similar proteins
    sd00039
    Location:70108
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:11183
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. XM_011534914.2XP_011533216.1  WD repeat and FYVE domain-containing protein 2 isoform X1

    Conserved Domains (4) summary
    COG2319
    Location:18272
    WD40; WD40 repeat [General function prediction only]
    cd15718
    Location:279348
    FYVE_WDFY1_like; FYVE domain found in WD40 repeat and FYVE domain-containing protein WDFY1 and WDFY2, and similar proteins
    sd00039
    Location:202239
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:16272
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  3. XM_047430089.1XP_047286045.1  WD repeat and FYVE domain-containing protein 2 isoform X4

  4. XM_024449317.2XP_024305085.1  WD repeat and FYVE domain-containing protein 2 isoform X2

    UniProtKB/TrEMBL
    Q96LK4
    Conserved Domains (3) summary
    cd15718
    Location:213282
    FYVE_WDFY1_like; FYVE domain found in WD40 repeat and FYVE domain-containing protein WDFY1 and WDFY2, and similar proteins
    sd00039
    Location:93131
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:2210
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  5. XM_047430088.1XP_047286044.1  WD repeat and FYVE domain-containing protein 2 isoform X3

    UniProtKB/TrEMBL
    Q96LK4
  6. XM_047430091.1XP_047286047.1  WD repeat and FYVE domain-containing protein 2 isoform X5

RNA

  1. XR_007063659.1 RNA Sequence

  2. XR_941483.2 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060937.1 Alternate T2T-CHM13v2.0

    Range
    50799394..50982622
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054374094.1XP_054230069.1  WD repeat and FYVE domain-containing protein 2 isoform X3

    UniProtKB/TrEMBL
    Q96LK4
  2. XM_054374093.1XP_054230068.1  WD repeat and FYVE domain-containing protein 2 isoform X1

  3. XM_054374095.1XP_054230070.1  WD repeat and FYVE domain-containing protein 2 isoform X4

  4. XM_054374096.1XP_054230071.1  WD repeat and FYVE domain-containing protein 2 isoform X5

RNA

  1. XR_008488729.1 RNA Sequence

  2. XR_008488730.1 RNA Sequence