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ZNF501 zinc finger protein 501 [ Homo sapiens (human) ]

Gene ID: 115560, updated on 2-Nov-2024

Summary

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Official Symbol
ZNF501provided by HGNC
Official Full Name
zinc finger protein 501provided by HGNC
Primary source
HGNC:HGNC:23717
See related
Ensembl:ENSG00000186446 AllianceGenome:HGNC:23717
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZNF; ZNF52
Summary
Enables sequence-specific double-stranded DNA binding activity. Involved in Golgi organization. Located in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in testis (RPKM 2.0), ovary (RPKM 1.9) and 25 other tissues See more
Orthologs
all
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Genomic context

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See ZNF501 in Genome Data Viewer
Location:
3p21.31
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (44729635..44737083)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (44745279..44752757)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (44771127..44778575)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377056 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr3:44761628-44762827 Neighboring gene suppressor of cytokine signaling 5 pseudogene 3 Neighboring gene zinc finger protein 502 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19770 Neighboring gene KIAA1143 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:44801624-44802266 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19771 Neighboring gene kinesin family member 15 Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 77

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Targeted protein unfolding uncovers a Golgi-specific transcriptional stress response. Serebrenik YV, et al. Mol Biol Cell, 2018 Jun 1. PMID 29851555, Free PMC Article
  2. Characterization and mapping of human genes encoding zinc finger proteins. Bray P, et al. Proc Natl Acad Sci U S A, 1991 Nov 1. PMID 1946370, Free PMC Article
  3. Clustering of C2-H2 zinc finger motif sequences within telomeric and fragile site regions of human chromosomes. Lichter P, et al. Genomics, 1992 Aug. PMID 1505991
  4. New host factors important for respiratory syncytial virus (RSV) replication revealed by a novel microfluidics screen for interactors of matrix (M) protein. Kipper S, et al. Mol Cell Proteomics, 2015 Mar. PMID 25556234, Free PMC Article
  5. ARHGAP24 represses β-catenin transactivation-induced invasiveness in hepatocellular carcinoma mainly by acting as a GTPase-independent scaffold. Yang W, et al. Theranostics, 2022. PMID 36168627, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC21738

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific double-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in Golgi organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
zinc finger protein 501
Names
zinc finger protein 52

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001258280.2 → NP_001245209.1  zinc finger protein 501

    See identical proteins and their annotated locations for NP_001245209.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate segment in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC013762, DB086337
    Consensus CDS
    CCDS2720.2
    UniProtKB/Swiss-Prot
    B4DLY7, Q96CX3, Q96NU9
    Related
    ENSP00000482632.1, ENST00000620116.5
    Conserved Domains (3) summary
    COG5048
    Location:20 → 256
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:108 → 128
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:120 → 145
    zf-H2C2_2; Zinc-finger double domain

  2. NM_145044.4 → NP_659481.2  zinc finger protein 501

    See identical proteins and their annotated locations for NP_659481.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC013762
    Consensus CDS
    CCDS2720.2
    UniProtKB/Swiss-Prot
    B4DLY7, Q96CX3, Q96NU9
    Related
    ENSP00000379363.2, ENST00000396048.6
    Conserved Domains (3) summary
    COG5048
    Location:20 → 256
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:108 → 128
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:120 → 145
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    44729635..44737083
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047447399.1 → XP_047303355.1  zinc finger protein 501 isoform X1

    UniProtKB/Swiss-Prot
    B4DLY7, Q96CX3, Q96NU9

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_009646197.1 Reference GRCh38.p14 PATCHES

    Range
    254955..262433
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054331541.1 → XP_054187516.1  zinc finger protein 501 isoform X1

    UniProtKB/Swiss-Prot
    B4DLY7, Q96CX3, Q96NU9

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    44745279..44752757
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054345137.1 → XP_054201112.1  zinc finger protein 501 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96CX3.2 GenPept UniProtKB/Swiss-Prot:Q96CX3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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