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CGAS cyclic GMP-AMP synthase [ Homo sapiens (human) ]

Gene ID: 115004, updated on 28-Nov-2021

Summary

Official Symbol
CGASprovided by HGNC
Official Full Name
cyclic GMP-AMP synthaseprovided by HGNC
Primary source
HGNC:HGNC:21367
See related
Ensembl:ENSG00000164430 MIM:613973
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MB21D1; h-cGAS; C6orf150
Expression
Broad expression in bone marrow (RPKM 4.9), lymph node (RPKM 3.8) and 24 other tissues See more
Orthologs
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Genomic context

See CGAS in Genome Data Viewer
Location:
6q13
Exon count:
5
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (73423711..73452297, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (74133434..74162020, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ribosomal protein S6 pseudogene 8 Neighboring gene DEAD-box helicase 43 Neighboring gene RNA, U6 small nuclear 975, pseudogene Neighboring gene mitochondrial tRNA translation optimization 1 Neighboring gene RNA, 7SL, cytoplasmic 827, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
capsid gag HIV-1 CA is a determinant of innate sensing of the viral cDNA by MB21D1 (cGAS) in dendritic cells (DCs). DCs sense capsid-mutated HIV-1 and enhance stimulation of T cells in the absence of productive infection PubMed
reverse transcriptase gag-pol HIV-1 infection induces the production of endogenous cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) in a manner that depends on cGAMP synthase (cGAS) and the reserve transcription of viral RNA to cDNA by RT PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC131892, MGC142166, MGC142168

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 2',3'-cyclic GMP-AMP synthase activity EXP
Inferred from Experiment
more info
PubMed 
enables 2',3'-cyclic GMP-AMP synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables 2',3'-cyclic GMP-AMP synthase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables double-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables double-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleosome binding IDA
Inferred from Direct Assay
more info
PubMed 
enables phosphatidylinositol-4,5-bisphosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
 
involved_in activation of innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in activation of innate immune response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in activation of innate immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cAMP-mediated signaling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cGMP-mediated signaling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to DNA damage stimulus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular response to DNA damage stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to exogenous dsRNA IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in defense response to virus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in determination of adult lifespan IEA
Inferred from Electronic Annotation
more info
 
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of double-strand break repair via homologous recombination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of double-strand break repair via homologous recombination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in paracrine signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in paracrine signaling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cAMP-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of cGMP-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of cellular senescence ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of defense response to virus by host IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of defense response to virus by host IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of defense response to virus by host IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of type I interferon production IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of type I interferon production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of type I interferon production TAS
Traceable Author Statement
more info
 
involved_in regulation of T cell activation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of immunoglobulin production IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in site of double-strand break IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in site of double-strand break IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
cyclic GMP-AMP synthase
Names
2'3'-cGAMP synthase
Mab-21 domain containing 1
cGAMP synthase
mab-21 domain-containing protein 1
protein MB21D1
NP_612450.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138441.3NP_612450.2  cyclic GMP-AMP synthase

    See identical proteins and their annotated locations for NP_612450.2

    Status: VALIDATED

    Source sequence(s)
    AC019205, AK097148, BC108714, DA375117
    Consensus CDS
    CCDS4978.1
    UniProtKB/Swiss-Prot
    Q8N884
    Related
    ENSP00000359339.3, ENST00000370315.4
    Conserved Domains (2) summary
    pfam03281
    Location:214510
    Mab-21; Mab-21 protein
    cl00936
    Location:15117
    RecX; RecX family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    73423711..73452297 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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