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Cgas cyclic GMP-AMP synthase [ Mus musculus (house mouse) ]

Gene ID: 214763, updated on 20-Feb-2024

Summary

Official Symbol
Cgasprovided by MGI
Official Full Name
cyclic GMP-AMP synthaseprovided by MGI
Primary source
MGI:MGI:2442261
See related
Ensembl:ENSMUSG00000032344 AllianceGenome:MGI:2442261
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mb21d1; E330016A19Rik
Summary
The protein encoded by this gene is a DNA binding cytosolic protein that catalyzes the synthesis of cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) after sensing the presence of DNA in the cytoplasm. cGAMP binds another protein, Stimulator of interferon genes (STING), leading to the induction of interferons, and a host immune response. Reduced expression of this gene inhibits interferon induction in the presence of some viral infections. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Expression
Ubiquitous expression in limb E14.5 (RPKM 1.2), liver E18 (RPKM 0.8) and 27 other tissues See more
Orthologs
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Genomic context

See Cgas in Genome Data Viewer
Location:
9 E1; 9 43.65 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (78337800..78350519, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (78430518..78443237, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene DEAD box helicase 43 Neighboring gene STARR-positive B cell enhancer mm9_chr9:78278373-78278674 Neighboring gene predicted gene 8093 Neighboring gene STARR-positive B cell enhancer ABC_E10565 Neighboring gene predicted gene, 17324 Neighboring gene mitochondrial tRNA translation optimization 1 Neighboring gene STARR-positive B cell enhancer ABC_E572 Neighboring gene eukaryotic translation elongation factor 1 alpha 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 2',3'-cyclic GMP-AMP synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables 2',3'-cyclic GMP-AMP synthase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables 2',3'-cyclic GMP-AMP synthase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables 2',3'-cyclic GMP-AMP synthase activity ISO
Inferred from Sequence Orthology
more info
 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
 
enables double-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables double-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables lipid binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables molecular condensate scaffold activity ISO
Inferred from Sequence Orthology
more info
 
enables nucleosome binding IDA
Inferred from Direct Assay
more info
PubMed 
enables nucleosome binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidylinositol-4,5-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
 
enables poly-ADP-D-ribose modification-dependent protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in DNA damage response IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
 
involved_in activation of innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in activation of innate immune response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in activation of innate immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in activation of innate immune response ISO
Inferred from Sequence Orthology
more info
 
involved_in cAMP-mediated signaling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cAMP-mediated signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cAMP-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in cGAS/STING signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in cGMP-mediated signaling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cGMP-mediated signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cGMP-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to exogenous dsRNA IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cellular response to exogenous dsRNA IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to exogenous dsRNA IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cytoplasmic pattern recognition receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in defense response to virus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in defense response to virus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within determination of adult lifespan IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
involved_in innate immune response ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of DNA repair IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of cGAS/STING signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of double-strand break repair via homologous recombination IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of double-strand break repair via homologous recombination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of double-strand break repair via homologous recombination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
 
involved_in paracrine signaling IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in paracrine signaling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in paracrine signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in pattern recognition receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cellular senescence IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of defense response to virus by host IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of defense response to virus by host IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of defense response to virus by host IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of defense response to virus by host ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of type I interferon production IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of type I interferon production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of type I interferon production ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of T cell activation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of immune response IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of immunoglobulin production IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of type I interferon production IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in site of double-strand break IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in site of double-strand break ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
cyclic GMP-AMP synthase
Names
2'3'-cGAMP synthase
Mab-21 domain containing 1
cGAMP synthase
mab-21 domain-containing protein 1
NP_775562.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173386.5NP_775562.2  cyclic GMP-AMP synthase

    See identical proteins and their annotated locations for NP_775562.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the functional protein.
    Source sequence(s)
    AC158987, AK030292, AK054330
    Consensus CDS
    CCDS40702.1
    UniProtKB/Swiss-Prot
    Q3ULW3, Q8C6L5
    UniProtKB/TrEMBL
    Q8BNZ9
    Related
    ENSMUSP00000063331.8, ENSMUST00000070742.14
    Conserved Domains (2) summary
    PHA03247
    Location:3142
    PHA03247; large tegument protein UL36; Provisional
    pfam03281
    Location:200495
    Mab-21; Mab-21 protein

RNA

  1. NR_125721.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternative splice site, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC158987

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    78337800..78350519 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)