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OSBPL11 oxysterol binding protein like 11 [ Homo sapiens (human) ]

Gene ID: 114885, updated on 5-Aug-2018

Summary

Official Symbol
OSBPL11provided by HGNC
Official Full Name
oxysterol binding protein like 11provided by HGNC
Primary source
HGNC:HGNC:16397
See related
Ensembl:ENSG00000144909 MIM:606739; Vega:OTTHUMG00000159571
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ORP11; ORP-11; OSBP12; TCCCIA00292
Summary
This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Like most members, the encoded protein contains an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in spleen (RPKM 8.5), brain (RPKM 8.2) and 25 other tissues See more
Orthologs

Genomic context

See OSBPL11 in Genome Data Viewer
Location:
3q21.2
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 3 NC_000003.12 (125528858..125595537, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (125247702..125314381, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374081 Neighboring gene sorting nexin 4 Neighboring gene HNF1 motif-containing MPRA enhancer 180 Neighboring gene uncharacterized LOC100419966 Neighboring gene myosin light chain kinase pseudogene Neighboring gene olfactory receptor family 7 subfamily E member 130 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ13012, FLJ13164

Gene Ontology Provided by GOA

Function Evidence Code Pubs
lipid binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lipid binding IEA
Inferred from Electronic Annotation
more info
 
sterol binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sterol transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
lipid transport IEA
Inferred from Electronic Annotation
more info
 
positive regulation of sequestering of triglyceride IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Golgi apparatus IDA
Inferred from Direct Assay
more info
 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
late endosome membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
oxysterol-binding protein-related protein 11
Names
OSBP-related protein 11
testicular tissue protein Li 132

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022776.4NP_073613.2  oxysterol-binding protein-related protein 11

    See identical proteins and their annotated locations for NP_073613.2

    Status: REVIEWED

    Source sequence(s)
    BC065213, BX506747, DA112146, DA722217
    Consensus CDS
    CCDS3033.1
    UniProtKB/Swiss-Prot
    Q9BXB4
    UniProtKB/TrEMBL
    A0A140VJQ6
    Related
    ENSP00000296220.5, OTTHUMP00000215865, ENST00000296220.5, OTTHUMT00000356295
    Conserved Domains (3) summary
    cd13291
    Location:61167
    PH_ORP10_ORP11; Human Oxysterol binding protein (OSBP) related proteins 10 and 11 (ORP10 and ORP11) Pleckstrin homology (PH) domain
    pfam00169
    Location:63153
    PH; PH domain
    pfam01237
    Location:372732
    Oxysterol_BP; Oxysterol-binding protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p12 Primary Assembly

    Range
    125528858..125595537 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_001739992.2 RNA Sequence

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