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OSBPL11 oxysterol binding protein like 11 [ Homo sapiens (human) ]

Gene ID: 114885, updated on 10-Dec-2024

Summary

Official Symbol
OSBPL11provided by HGNC
Official Full Name
oxysterol binding protein like 11provided by HGNC
Primary source
HGNC:HGNC:16397
See related
Ensembl:ENSG00000144909 MIM:606739; AllianceGenome:HGNC:16397
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ORP11; ORP-11; OSBP12; TCCCIA00292
Summary
This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Like most members, the encoded protein contains an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in spleen (RPKM 8.5), brain (RPKM 8.2) and 25 other tissues See more
Orthologs
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Genomic context

See OSBPL11 in Genome Data Viewer
Location:
3q21.2
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (125528858..125595497, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (128255468..128322119, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (125247702..125314341, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA U13 Neighboring gene sorting nexin 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20430 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:125238317-125238818 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14667 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20431 Neighboring gene HNF1 motif-containing MPRA enhancer 180 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20432 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20433 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14668 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20434 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:125390028-125390702 Neighboring gene uncharacterized LOC100419966 Neighboring gene YTHDF3 pseudogene 1 Neighboring gene MYLK pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ13012, FLJ13164

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sterol binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in lipid transport IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of sequestering of triglyceride IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in late endosome membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
oxysterol-binding protein-related protein 11
Names
OSBP-related protein 11
testicular tissue protein Li 132

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022776.5NP_073613.2  oxysterol-binding protein-related protein 11

    See identical proteins and their annotated locations for NP_073613.2

    Status: REVIEWED

    Source sequence(s)
    BC065213, BX506747, DA112146, DA722217
    Consensus CDS
    CCDS3033.1
    UniProtKB/Swiss-Prot
    A8K9I7, Q9BXB4
    UniProtKB/TrEMBL
    A0A140VJQ6
    Related
    ENSP00000296220.5, ENST00000296220.6
    Conserved Domains (3) summary
    cd13291
    Location:61167
    PH_ORP10_ORP11; Human Oxysterol binding protein (OSBP) related proteins 10 and 11 (ORP10 and ORP11) Pleckstrin homology (PH) domain
    pfam00169
    Location:63153
    PH; PH domain
    pfam01237
    Location:372732
    Oxysterol_BP; Oxysterol-binding protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    125528858..125595497 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047447396.1XP_047303352.1  oxysterol-binding protein-related protein 11 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    128255468..128322119 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054345134.1XP_054201109.1  oxysterol-binding protein-related protein 11 isoform X1