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Osbpl11 oxysterol binding protein-like 11 [ Mus musculus (house mouse) ]

Gene ID: 106326, updated on 26-Sep-2022

Summary

Official Symbol
Osbpl11provided by MGI
Official Full Name
oxysterol binding protein-like 11provided by MGI
Primary source
MGI:MGI:2146553
See related
Ensembl:ENSMUSG00000022807 AllianceGenome:MGI:2146553
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ORP-11; 9430097N02Rik
Summary
Predicted to enable sterol binding activity and sterol transporter activity. Predicted to be involved in fat cell differentiation and positive regulation of sequestering of triglyceride. Predicted to act upstream of or within lipid transport. Predicted to be located in Golgi apparatus and nucleoplasm. Predicted to be active in cytosol; intracellular membrane-bounded organelle; and membrane. Is expressed in several structures, including central nervous system; genitourinary system; heart; immune system; and lung. Orthologous to human OSBPL11 (oxysterol binding protein like 11). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in subcutaneous fat pad adult (RPKM 10.9), thymus adult (RPKM 8.7) and 28 other tissues See more
Orthologs
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Genomic context

See Osbpl11 in Genome Data Viewer
Location:
16; 16 B3
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (33005441..33063682)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (33169763..33243312)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41447 Neighboring gene predicted gene, 53950 Neighboring gene predicted gene, 52274 Neighboring gene sorting nexin 4

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables lipid binding IEA
Inferred from Electronic Annotation
more info
 
enables sterol binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables sterol transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in fat cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lipid transport IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of sequestering of triglyceride ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
oxysterol-binding protein-related protein 11
Names
OSBP-related protein 11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_176840.3NP_789810.2  oxysterol-binding protein-related protein 11

    See identical proteins and their annotated locations for NP_789810.2

    Status: VALIDATED

    Source sequence(s)
    AC124195, AC145198
    Consensus CDS
    CCDS28128.1
    UniProtKB/TrEMBL
    G5E8A0
    Related
    ENSMUSP00000039632.9, ENSMUST00000039733.10
    Conserved Domains (3) summary
    cd13291
    Location:72178
    PH_ORP10_ORP11; Human Oxysterol binding protein (OSBP) related proteins 10 and 11 (ORP10 and ORP11) Pleckstrin homology (PH) domain
    pfam00169
    Location:74164
    PH; PH domain
    pfam01237
    Location:383743
    Oxysterol_BP; Oxysterol-binding protein

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    33005441..33063682
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)