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SAAL1 serum amyloid A like 1 [ Homo sapiens (human) ]

Gene ID: 113174, updated on 1-Mar-2024

Summary

Official Symbol
SAAL1provided by HGNC
Official Full Name
serum amyloid A like 1provided by HGNC
Primary source
HGNC:HGNC:25158
See related
Ensembl:ENSG00000166788 AllianceGenome:HGNC:25158
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SPACIA1
Summary
Acts upstream of or within positive regulation of synoviocyte proliferation. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 8.1), lymph node (RPKM 7.2) and 25 other tissues See more
Orthologs
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Genomic context

See SAAL1 in Genome Data Viewer
Location:
11p15.1
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (18080292..18106082, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (18175834..18201627, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (18101839..18127629, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene secretion regulating guanine nucleotide exchange factor Neighboring gene uncharacterized LOC124902642 Neighboring gene uncharacterized LOC107984317 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:17888867-17889368 Neighboring gene NANOG hESC enhancer GRCh37_chr11:17920239-17920740 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3188 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:18032869-18033386 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:18033387-18033903 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3189 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4489 Neighboring gene tryptophan hydroxylase 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4490 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4491 Neighboring gene HIG1 hypoxia inducible domain family member 1A pseudogene 5 Neighboring gene serum amyloid A3, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of SAAL1 PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ41463

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Component Evidence Code Pubs
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
protein SAAL1
Names
synoviocyte proliferation-associated in collagen-induced arthritis 1
synoviocyte proliferation-associated in collagen-induced arthritis protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138421.3NP_612430.2  protein SAAL1

    See identical proteins and their annotated locations for NP_612430.2

    Status: VALIDATED

    Source sequence(s)
    AC090099, BC012010, BU150462, DR155913
    Consensus CDS
    CCDS31439.1
    UniProtKB/Swiss-Prot
    A6NH05, Q96ER3
    UniProtKB/TrEMBL
    G1UCX3, J3KND1
    Related
    ENSP00000432487.1, ENST00000524803.6

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    18080292..18106082 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    18175834..18201627 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)