Saal1 serum amyloid A-like 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Saal1provided by MGI
Official Full Name: serum amyloid A-like 1provided by MGI
Primary source: MGI:MGI:1926185
See related: Ensembl:ENSMUSG00000006763 AllianceGenome:MGI:1926185
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: SPACIA1; 5031425D22Rik
Summary: Predicted to act upstream of or within positive regulation of synoviocyte proliferation. Predicted to be located in nucleoplasm. Orthologous to human SAAL1 (serum amyloid A like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 5.2), limb E14.5 (RPKM 4.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7; 7 B3

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (46335532..46360113, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (46686108..46710690, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Overexpression of SPACIA1/SAAL1, a newly identified gene that is involved in synoviocyte proliferation, accelerates the progression of synovitis in mice and humans.
Title: Overexpression of SPACIA1/SAAL1, a newly identified gene that is involved in synoviocyte proliferation, accelerates the progression of synovitis in mice and humans.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH137346 (e-PCR)
- UniSTS:219434

AV098916 (e-PCR)
- UniSTS:165526

NoName (e-PCR)
- UniSTS:235671

NoName (e-PCR)
- UniSTS:235672

X03505 (e-PCR)
- UniSTS:159645

Homology

Homologs of the Saal1 gene: The Saal1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 503 organisms have orthologs with human gene Saal1
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in positive regulation of synoviocyte proliferation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within positive regulation of synoviocyte proliferation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein SAAL1

Names: synoviocyte proliferation-associated in collagen-induced arthritis 1; synoviocyte proliferation-associated in collagen-induced arthritis protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.