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CDCA5 cell division cycle associated 5 [ Homo sapiens (human) ]

Gene ID: 113130, updated on 17-Jun-2019

Summary

Official Symbol
CDCA5provided by HGNC
Official Full Name
cell division cycle associated 5provided by HGNC
Primary source
HGNC:HGNC:14626
See related
Ensembl:ENSG00000146670 MIM:609374
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SORORIN
Expression
Biased expression in bone marrow (RPKM 12.1), testis (RPKM 11.0) and 13 other tissues See more
Orthologs

Genomic context

See CDCA5 in Genome Data Viewer
Location:
11q13.1
Exon count:
16
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (65061009..65084129, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (64833772..64851635, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene ARL2-SNX15 readthrough (NMD candidate) Neighboring gene Sharpr-MPRA regulatory region 4003 Neighboring gene sorting nexin 15 Neighboring gene SAC3 domain containing 1 Neighboring gene N-acetylated alpha-linked acidic dipeptidase like 1 Neighboring gene zinc finger protein like 1 Neighboring gene transmembrane protein 262 Neighboring gene VPS51 subunit of GARP complex Neighboring gene transmembrane 7 superfamily member 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Cell Cycle, organism-specific biosystem (from REACTOME)
    Cell Cycle, organism-specific biosystem
    Cell Cycle
  • Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
    Cell Cycle, Mitotic, organism-specific biosystemThe replication of the genome and the subsequent segregation of chromosomes into daughter cells are controlled by a series of events collectively known as the cell cycle. DNA replication is carried o...
  • Establishment of Sister Chromatid Cohesion, organism-specific biosystem (from REACTOME)
    Establishment of Sister Chromatid Cohesion, organism-specific biosystemThe cohesin complex loads onto chromatin in telophase, but its association with chromatin remains transient, dynamic until the S-phase of the cell cycle, presumably because the cohesin-bound NIPBL:MA...
  • M Phase, organism-specific biosystem (from REACTOME)
    M Phase, organism-specific biosystemMitosis, or the M phase, involves nuclear division and cytokinesis, where two identical daughter cells are produced. Mitosis involves prophase, prometaphase, metaphase, anaphase, and telophase. Fin...
  • MicroRNAs in cancer, organism-specific biosystem (from KEGG)
    MicroRNAs in cancer, organism-specific biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
  • MicroRNAs in cancer, conserved biosystem (from KEGG)
    MicroRNAs in cancer, conserved biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
  • Mitotic Anaphase, organism-specific biosystem (from REACTOME)
    Mitotic Anaphase, organism-specific biosystemIn anaphase, the paired chromosomes separate at the centromeres, and move to the opposite sides of the cell. The movement of the chromosomes is facilitated by a combination of kinetochore movement al...
  • Mitotic Metaphase and Anaphase, organism-specific biosystem (from REACTOME)
    Mitotic Metaphase and Anaphase, organism-specific biosystemMetaphase is marked by the formation of the metaphase plate. The metaphase plate is formed when the spindle fibers align the chromosomes along the middle of the cell. Such an organization helps to ...
  • Mitotic Prometaphase, organism-specific biosystem (from REACTOME)
    Mitotic Prometaphase, organism-specific biosystemThe dissolution of the nuclear membrane marks the beginning of the prometaphase. Kinetochores are created when proteins attach to the centromeres. Microtubules then attach at the kinetochores, and th...
  • Resolution of Sister Chromatid Cohesion, organism-specific biosystem (from REACTOME)
    Resolution of Sister Chromatid Cohesion, organism-specific biosystemThe resolution of sister chromatids in mitotic prometaphase involves removal of cohesin complexes from chromosomal arms, with preservation of cohesion at centromeres (Losada et al. 1998, Hauf et al. ...
  • S Phase, organism-specific biosystem (from REACTOME)
    S Phase, organism-specific biosystemDNA synthesis occurs in the S phase, or the synthesis phase, of the cell cycle. The cell duplicates its hereditary material, and two copies of the chromosome are formed. As DNA replication continues,...
  • Separation of Sister Chromatids, organism-specific biosystem (from REACTOME)
    Separation of Sister Chromatids, organism-specific biosystemWhile sister chromatids resolve in prometaphase, separating along chromosomal arms, the cohesion of sister centromeres persists until anaphase. At the anaphase onset, the anaphase promoting complex/c...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC16386

Gene Ontology Provided by GOA

Function Evidence Code Pubs
chromatin binding TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein-containing complex binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
cell division IEA
Inferred from Electronic Annotation
more info
 
double-strand break repair IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
double-strand break repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitotic cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
mitotic chromosome condensation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitotic chromosome condensation IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitotic metaphase plate congression IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitotic metaphase plate congression IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitotic sister chromatid cohesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitotic sister chromatid cohesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitotic sister chromatid cohesion IPI
Inferred from Physical Interaction
more info
PubMed 
positive regulation of exit from mitosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of exit from mitosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cohesin loading IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of cohesin loading IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
chromosome TAS
Traceable Author Statement
more info
 
chromosome, centromeric region TAS
Traceable Author Statement
more info
 
cohesin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
colocalizes_with cohesin complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosol TAS
Traceable Author Statement
more info
 
nuclear chromatin ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
sororin
Names
cell division cycle-associated protein 5
p35

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_080668.4NP_542399.1  sororin

    See identical proteins and their annotated locations for NP_542399.1

    Status: VALIDATED

    Source sequence(s)
    AP003068, BC011000
    Consensus CDS
    CCDS8091.1
    UniProtKB/Swiss-Prot
    Q96FF9
    UniProtKB/TrEMBL
    A0A024R5D6
    Related
    ENSP00000275517.3, ENST00000275517.8
    Conserved Domains (1) summary
    pfam09666
    Location:89209
    Sororin; Sororin protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    65061009..65084129 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011544743.3XP_011543045.1  sororin isoform X3

    Conserved Domains (1) summary
    pfam09666
    Location:89209
    Sororin; Sororin protein
  2. XM_017017158.2XP_016872647.1  sororin isoform X4

  3. XM_011544747.3XP_011543049.1  sororin isoform X5

  4. XM_005273733.4XP_005273790.1  sororin isoform X1

    Conserved Domains (1) summary
    pfam09666
    Location:89209
    Sororin; Sororin protein
  5. XM_005273734.4XP_005273791.1  sororin isoform X2

    Conserved Domains (1) summary
    pfam09666
    Location:89209
    Sororin; Sororin protein
  6. XM_011544749.3XP_011543051.1  sororin isoform X7

    Conserved Domains (1) summary
    pfam09666
    Location:89209
    Sororin; Sororin protein
  7. XM_011544748.3XP_011543050.1  sororin isoform X6

    Conserved Domains (1) summary
    pfam09666
    Location:89209
    Sororin; Sororin protein

RNA

  1. XR_001747758.2 RNA Sequence

  2. XR_001747757.2 RNA Sequence

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