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CDCA5 cell division cycle associated 5 [ Homo sapiens (human) ]

Gene ID: 113130, updated on 2-Nov-2024

Summary

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Official Symbol
CDCA5provided by HGNC
Official Full Name
cell division cycle associated 5provided by HGNC
Primary source
HGNC:HGNC:14626
See related
Ensembl:ENSG00000146670 MIM:609374; AllianceGenome:HGNC:14626
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SORORIN
Summary
Predicted to enable chromatin binding activity. Involved in chromosome organization; double-strand break repair; and positive regulation of exit from mitosis. Located in nucleoplasm. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in bone marrow (RPKM 12.1), testis (RPKM 11.0) and 13 other tissues See more
Orthologs
mouse all
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Genomic context

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See CDCA5 in Genome Data Viewer
Location:
11q13.1
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (65061093..65084040, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (65054375..65077318, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (64844925..64851512, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene ARL2-SNX15 readthrough (NMD candidate) Neighboring gene Sharpr-MPRA regulatory region 4003 Neighboring gene sorting nexin 15 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4937 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4938 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3506 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3507 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:64811302-64811848 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:64814570-64815448 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:64815449-64816327 Neighboring gene SAC3 domain containing 1 Neighboring gene N-acetylated alpha-linked acidic dipeptidase like 1 Neighboring gene Sharpr-MPRA regulatory region 288 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:64846103-64846604 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4939 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4940 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:64852413-64852997 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:64857368-64857540 Neighboring gene zinc finger protein like 1 Neighboring gene transmembrane protein 262 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:64863491-64864285 Neighboring gene Sharpr-MPRA regulatory region 6888 Neighboring gene VPS51 subunit of GARP complex Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:64877599-64878526 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:64878527-64879452

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. CDCA5 promoted cell invasion and migration by activating TGF-β1 pathway in human ovarian cancer cells. Zhang Q, et al. J Ovarian Res, 2024 Mar 27. PMID 38539247, Free PMC Article
  2. Regulation of centromeric cohesion by sororin independently of the APC/C. Díaz-Martínez LA, et al. Cell Cycle, 2007 Mar 15. PMID 17361102
  3. Phosphorylation and activation of cell division cycle associated 5 by mitogen-activated protein kinase play a crucial role in human lung carcinogenesis. Nguyen MH, et al. Cancer Res, 2010 Jul 1. PMID 20551060
  4. A conserved motif at the C terminus of sororin is required for sister chromatid cohesion. Wu FM, et al. J Biol Chem, 2011 Feb 4. PMID 21115494, Free PMC Article
  5. C-terminus of Sororin interacts with SA2 and regulates sister chromatid cohesion. Zhang N, et al. Cell Cycle, 2015. PMID 25608232, Free PMC Article

See all (80) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CDCA5 accelerates progression of breast cancer by promoting the binding of E2F1 and FOXM1.
    Title: CDCA5 accelerates progression of breast cancer by promoting the binding of E2F1 and FOXM1.
  2. CDCA5 promoted cell invasion and migration by activating TGF-beta1 pathway in human ovarian cancer cells.
    Title: CDCA5 promoted cell invasion and migration by activating TGF-β1 pathway in human ovarian cancer cells.
  3. KLF5-mediated CDCA5 expression promotes tumor development and progression of epithelial ovarian carcinoma.
    Title: KLF5-mediated CDCA5 expression promotes tumor development and progression of epithelial ovarian carcinoma.
  4. CDCA5 promotes the progression of breast cancer and serves as a potential prognostic biomarker.
    Title: CDCA5 promotes the progression of breast cancer and serves as a potential prognostic biomarker.
  5. Loss of cell division cycleassociated 5 promotes cell apoptosis by activating DNA damage response in clear cell renal cell carcinoma.
    Title: Loss of cell division cycle‑associated 5 promotes cell apoptosis by activating DNA damage response in clear cell renal cell carcinoma.
  6. Knockdown of CDCA5 suppresses malignant progression of breast cancer cells by regulating PDS5A.
    Title: Knockdown of CDCA5 suppresses malignant progression of breast cancer cells by regulating PDS5A.
  7. Silencing oncogene cell division cycle associated 5 induces apoptosis and G1 phase arrest of non-small cell lung cancer cells via p53-p21 signaling pathway.
    Title: Silencing oncogene cell division cycle associated 5 induces apoptosis and G1 phase arrest of non-small cell lung cancer cells via p53-p21 signaling pathway.
  8. TPI1 activates the PI3K/AKT/mTOR signaling pathway to induce breast cancer progression by stabilizing CDCA5.
    Title: TPI1 activates the PI3K/AKT/mTOR signaling pathway to induce breast cancer progression by stabilizing CDCA5.
  9. CDCA5 is negatively regulated by miR-326 and boosts ovarian cancer progression.
    Title: CDCA5 is negatively regulated by miR-326 and boosts ovarian cancer progression.
  10. LINC01515 promotes nasopharyngeal carcinoma progression by serving as a sponge for miR-325 to up-regulate CDCA5.
    Title: LINC01515 promotes nasopharyngeal carcinoma progression by serving as a sponge for miR-325 to up-regulate CDCA5.
Submit: New GeneRIF Correction See all GeneRIFs (36)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC16386

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables chromatin binding TAS
Traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-containing complex binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in double-strand break repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in double-strand break repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic cell cycle IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mitotic chromosome condensation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic metaphase chromosome alignment IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic metaphase chromosome alignment IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic sister chromatid cohesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic sister chromatid cohesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic sister chromatid cohesion IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in positive regulation of exit from mitosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of exit from mitosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chromatin ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in chromosome TAS
Traceable Author Statement
more info
  
located_in chromosome, centromeric region TAS
Traceable Author Statement
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
sororin
Names
cell division cycle-associated protein 5
p35

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001433518.1 → NP_001420447.1  sororin isoform 2

    Status: VALIDATED

    Source sequence(s)
    AP003068

  2. NM_080668.4 → NP_542399.1  sororin isoform 1

    See identical proteins and their annotated locations for NP_542399.1

    Status: VALIDATED

    Source sequence(s)
    AP003068, BC011000
    Consensus CDS
    CCDS8091.1
    UniProtKB/Swiss-Prot
    A8K625, Q96FF9
    UniProtKB/TrEMBL
    B5MBX0
    Related
    ENSP00000275517.3, ENST00000275517.8
    Conserved Domains (1) summary
    pfam09666
    Location:89 → 209
    Sororin; Sororin protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    65061093..65084040 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011544743.4 → XP_011543045.1  sororin isoform X3

    Conserved Domains (1) summary
    pfam09666
    Location:89 → 209
    Sororin; Sororin protein

  2. XM_017017158.3 → XP_016872647.1  sororin isoform X4

  3. XM_011544747.4 → XP_011543049.1  sororin isoform X5

  4. XM_005273734.5 → XP_005273791.1  sororin isoform X2

    Conserved Domains (1) summary
    pfam09666
    Location:89 → 209
    Sororin; Sororin protein

  5. XM_005273733.5 → XP_005273790.1  sororin isoform X1

    Conserved Domains (1) summary
    pfam09666
    Location:89 → 209
    Sororin; Sororin protein

  6. XM_011544749.4 → XP_011543051.1  sororin isoform X7

    Conserved Domains (1) summary
    pfam09666
    Location:89 → 209
    Sororin; Sororin protein

  7. XM_011544748.4 → XP_011543050.1  sororin isoform X6

    Conserved Domains (1) summary
    pfam09666
    Location:89 → 209
    Sororin; Sororin protein

RNA

  1. XR_001747758.3 RNA Sequence

  2. XR_001747757.3 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    65054375..65077318 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054367586.1 → XP_054223561.1  sororin isoform X3

  2. XM_054367587.1 → XP_054223562.1  sororin isoform X4

  3. XM_054367588.1 → XP_054223563.1  sororin isoform X5

  4. XM_054367584.1 → XP_054223559.1  sororin isoform X1

  5. XM_054367585.1 → XP_054223560.1  sororin isoform X2

  6. XM_054367590.1 → XP_054223565.1  sororin isoform X7

  7. XM_054367589.1 → XP_054223564.1  sororin isoform X6

RNA

  1. XR_008488337.1 RNA Sequence

  2. XR_008488336.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96FF9.1 GenPept UniProtKB/Swiss-Prot:Q96FF9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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