Conserved Protein Domain Family
Sororin

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pfam09666: Sororin (this model, PSSM-Id:286714 is obsolete and has been replaced by 312979)
Sororin protein
Sororin is an essential, cell cycle-dependent mediator of sister chromatid cohesion. The protein is nuclear in interphase cells, dispersed from the chromatin in mitosis, and interacts with the cohesin complex.
Statistics
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PSSM-Id: 286714
View PSSM: pfam09666
Aligned: 14 rows
Threshold Bit Score: 74.8781
Threshold Setting Gi: 155369321
Created: 13-Jul-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121991878 312 ENLPPTVAH-------K-------TPTTANDQEDAENVENVVHLPNPRRTLQERaplKDINILDVVVLPSWKKNIQvtpi 377
gi 68565272   88 ENNPPLKVPtke-dlfK-------TCSVPGTPSSTPVLYTQNVEPDSGEAELDS---RDLEMSQKVRRSYSRLQSL---- 152
gi 122138178 114 ENNPPSK-KltkedlfH-------TCSVPVTAPSTPVLCPVNAESNSWKGDLDA---RDLEMSKKVRRSYSRLETL---- 178
gi 194902849 471 ENRPPPTIN---------------TSMPINDQESAENTDNFVHLPNPRRTVQKRmpfKDINILEVMTLPPWKKNVPatis 535
gi 195330314 309 ENRPPPTIS---------------KSMSINDQESEENAENFVHLPNPRRTLQKRtpfKDINILEVVTLPSWKKNVTtnvs 373
gi 195445888 380 ENMPP-----------------------VATPAGNENMENLVHLPNPRRTLQNRmplKDINILEVVHLPPWKKNPLgqat 436
gi 195113933 455 ENVPPSAAA-------TetstgpqSLTTIEPVDNNENVTNLVQLPNPRRALKYRsplKDINILDVVVLPSWKKNVQqknn 527
gi 187608795  91 ENAISEKSQ-------MvpkeatsKPSAPEIDVLSPIPVNIQMSSNQDN--------RDIVMSQKVRRSYSRLEMSlnss 155
gi 148228887  86 ENAFSEQSQ-------IvhkdvpgQSSAPKINVLSPIPVNIQLSPKQDN--------RDIIMSQKVRRSYSRLEMSlnss 150
gi 18087845   89 ENEPPGREL-------Tked-lfkTHSVPATPTSTPVP-NPEAESSSKEGELDA---RDLEMSKKVRRSYSRLETL---- 152
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121991878 378 t--------------------------ptkatT------PAMTSSPanqffgfdefleeenspkrrrTERnttvhtpsks 425
gi 68565272  153 --------------------------------G------CASTSTP---------------------GRR---------- 163
gi 122138178 179 --------------------------------G------SASTSTP---------------------GRQ---------- 189
gi 194902849 536 kei----------------------tptkvdpH------PIATSSPaqr----------------tqTRV---------- 561
gi 195330314 374 kev----------------------tptrvapR------PMATSSPaqr----------------sqTRS---------- 399
gi 195445888 437 plk-----------------------desalrDai---sPITQRSSsdh---------------srrESR---------- 465
gi 195113933 528 tptkeslssnqqqefnsnipgqqtsknptkesQtryeqqELNSYSPehqcard--------kqeqqrQGC---------- 589
gi 187608795 156 sfl----------------------ysptrktD------SSDTSTPnav---------------pksGRR---------- 182
gi 148228887 151 ssl----------------------ysptrktD------SSDTSTPnvv---------------lksGRS---------- 177
gi 18087845  153 --------------------------------G------SASTSTP---------------------GRR---------- 163
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 121991878 426 gNLFGFEEfleGDEaa----eSRGSTSAPQNVTLHEKLQ--------RLKQLRP-------TEKELPQVSTAPLRR 482
gi 68565272  164 -SFFGFEG---PDD-------LPGVSPVVCSKLIETPKVpakdlvpaRTKDLVPdstkdlvPARTLPGISPPVVKE 228
gi 122138178 190 -SCFGFEGllaAED-------LAGVSPVVDSKLAEVPRV--------SVKPWAP--------DTTLPGISPLVVKE 241
gi 194902849 562 -NLFGYDDalsCEDi-----pRKTTTPSKGIAHTSVSFN--------REVTTAL-------ANRNQMDVNTFGCQE 616
gi 195330314 400 -NLFGFDDdlaCEDi-----lTKSTTPSKGIAATSVSFN--------REVTPAL-------ANRSQMEVNTSECNE 454
gi 195445888 466 -NLFGFEEfldPNEhs---qhEVQATALSQDQTLNDKLQ--------RMKRLRP-------VDRDFPQVASTPLRY 522
gi 195113933 590 -DLFGFEDflsEEDeicvrepNQSVTKSCTDTTLHEKLQ--------RLKNLRP-------AQQELPQVSQAPMRH 649
gi 187608795 183 -SLFGFDKllnSEMpe---geLRKSGSGTREKTANEKTL--------GTILPEE-------PDHNIPGVvlakqkr 239
gi 148228887 178 -SLFGFDKllnSEMpd---geLKKSNGVTRKKNTKERIL--------GTVLPEQ-------PDHNIPGVvlakqkr 234
gi 18087845  164 -SCFGFEGllgAED-------LSGVSPVVCSKLTEVPRV--------CAKPWAP--------DMTLPGISpppekq 215
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