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CHRM3 cholinergic receptor muscarinic 3 [ Homo sapiens (human) ]

Gene ID: 1131, updated on 18-Sep-2018

Summary

Official Symbol
CHRM3provided by HGNC
Official Full Name
cholinergic receptor muscarinic 3provided by HGNC
Primary source
HGNC:HGNC:1952
See related
Ensembl:ENSG00000133019 MIM:118494; Vega:OTTHUMG00000039649
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HM3; PBS; EGBRS
Summary
The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 3 controls smooth muscle contraction and its stimulation causes secretion of glandular tissue. Alternative promoter use and alternative splicing results in multiple transcript variants that have different tissue specificities. [provided by RefSeq, Dec 2016]
Expression
Biased expression in brain (RPKM 5.0), salivary gland (RPKM 2.4) and 12 other tissues See more
Orthologs

Genomic context

See CHRM3 in Genome Data Viewer
Location:
1q43
Exon count:
16
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (239386565..239915450)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (239549876..240078750)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein L39 pseudogene 10 Neighboring gene uncharacterized LOC105373223 Neighboring gene uncharacterized LOC105373225 Neighboring gene CHRM3 antisense RNA 2 Neighboring gene uncharacterized LOC105373224 Neighboring gene CHRM3 antisense RNA 1 Neighboring gene 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble) pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Prune belly syndrome
MedGen: C0033770 OMIM: 100100 GeneReviews: Not available
Compare labs

Copy number response

Description
Copy number response
Triplosensitivity

No evidence available (Last evaluated (2015-03-11)

ClinGen Genome Curation Page
Haploinsufficency

Little evidence for dosage pathogenicity (Last evaluated (2015-03-11)

ClinGen Genome Curation PagePubMed

NHGRI GWAS Catalog

Description
A genome-wide search for common SNP x SNP interactions on the risk of venous thrombosis.
NHGRI GWA Catalog
Duffy-null-associated low neutrophil counts influence HIV-1 susceptibility in high-risk South African black women.
NHGRI GWA Catalog
Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans.
NHGRI GWA Catalog
Genome-wide association analysis of genetic generalized epilepsies implicates susceptibility loci at 1q43, 2p16.1, 2q22.3 and 17q21.32
NHGRI GWA Catalog
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.
NHGRI GWA Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of CHRM3 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Acetylcholine regulates insulin secretion, organism-specific biosystem (from REACTOME)
    Acetylcholine regulates insulin secretion, organism-specific biosystemAcetylcholine released by parasympathetic nerve endings in the pancreas causes a potentiation of insulin release when glucose is present at concentrations greater than about 7 mM. Acetylcholine binds...
  • Amine ligand-binding receptors, organism-specific biosystem (from REACTOME)
    Amine ligand-binding receptors, organism-specific biosystemThe class A (rhodopsin-like) GPCRs that bind to classical biogenic amine ligands are annotated here. The amines involved (acetylcholine, adrenaline, noradrenaline, dopamine, serotonin and histamine)...
  • Calcium Regulation in the Cardiac Cell, organism-specific biosystem (from WikiPathways)
    Calcium Regulation in the Cardiac Cell, organism-specific biosystemCalcium is a common signaling mechanism, as once it enters the cytoplasm it exerts allosteric regulatory affects on many enzymes and proteins. Calcium can act in signal transduction after influx resu...
  • Calcium signaling pathway, organism-specific biosystem (from KEGG)
    Calcium signaling pathway, organism-specific biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
  • Calcium signaling pathway, conserved biosystem (from KEGG)
    Calcium signaling pathway, conserved biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
  • Cholinergic synapse, organism-specific biosystem (from KEGG)
    Cholinergic synapse, organism-specific biosystemAcetylcholine (ACh) is a neurotransmitter widely distributed in the central (and also peripheral, autonomic and enteric) nervous system (CNS). In the CNS, ACh facilitates many functions, such as lear...
  • Class A/1 (Rhodopsin-like receptors), organism-specific biosystem (from REACTOME)
    Class A/1 (Rhodopsin-like receptors), organism-specific biosystemRhodopsin-like receptors (class A/1) are the largest group of GPCRs and are the best studied group from a functional and structural point of view. They show great diversity at the sequence level and ...
  • G alpha (q) signalling events, organism-specific biosystem (from REACTOME)
    G alpha (q) signalling events, organism-specific biosystemThe classic signalling route for G alpha (q) is activation of phospholipase C beta thereby triggering phosphoinositide hydrolysis, calcium mobilization and protein kinase C activation. This provides ...
  • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
    GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
  • GPCR ligand binding, organism-specific biosystem (from REACTOME)
    GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
  • GPCRs, Class A Rhodopsin-like, organism-specific biosystem (from WikiPathways)
    GPCRs, Class A Rhodopsin-like, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.gpcr.org/7tm/ (originally at http://www.cmbi.kun.nl/7tm/). The groupings are based on the GPCR phylogenetic tree available fr...
  • GPCRs, Other, organism-specific biosystem (from WikiPathways)
    GPCRs, Other, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.gpcr.org/7tm/ (originally at http://www.cmbi.kun.nl/7tm/). The groupings are based on the GPCR phylogenetic tree available fr...
  • Gastric acid secretion, organism-specific biosystem (from KEGG)
    Gastric acid secretion, organism-specific biosystemGastric acid is a key factor in normal upper gastrointestinal functions, including protein digestion and calcium and iron absorption, as well as providing some protection against bacterial infections...
  • Gastric acid secretion, conserved biosystem (from KEGG)
    Gastric acid secretion, conserved biosystemGastric acid is a key factor in normal upper gastrointestinal functions, including protein digestion and calcium and iron absorption, as well as providing some protection against bacterial infections...
  • Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystem (from REACTOME)
    Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystemGastrin is a hormone whose main function is to stimulate secretion of hydrochloric acid by the gastric mucosa, which results in gastrin formation inhibition. This hormone also acts as a mitogenic fac...
  • Insulin secretion, organism-specific biosystem (from KEGG)
    Insulin secretion, organism-specific biosystemPancreatic beta cells are specialised endocrine cells that continuously sense the levels of blood sugar and other fuels and, in response, secrete insulin to maintain normal fuel homeostasis. Glucose-...
  • Integration of energy metabolism, organism-specific biosystem (from REACTOME)
    Integration of energy metabolism, organism-specific biosystemMany hormones that affect individual physiological processes including the regulation of appetite, absorption, transport, and oxidation of foodstuffs influence energy metabolism pathways. While insul...
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Monoamine GPCRs, organism-specific biosystem (from WikiPathways)
    Monoamine GPCRs, organism-specific biosystem
    Monoamine GPCRs
  • Muscarinic acetylcholine receptors, organism-specific biosystem (from REACTOME)
    Muscarinic acetylcholine receptors, organism-specific biosystemMuscarinic acetylcholine (mAChRs) receptors were so named because they are more sensitive to muscarine than to nicotine (Ishii M and Kurachi Y, 2006). Their counterparts are nicotinic acetylcholine r...
  • Neuroactive ligand-receptor interaction, organism-specific biosystem (from KEGG)
    Neuroactive ligand-receptor interaction, organism-specific biosystem
    Neuroactive ligand-receptor interaction
  • Neuroactive ligand-receptor interaction, conserved biosystem (from KEGG)
    Neuroactive ligand-receptor interaction, conserved biosystem
    Neuroactive ligand-receptor interaction
  • Pancreatic secretion, organism-specific biosystem (from KEGG)
    Pancreatic secretion, organism-specific biosystemThe pancreas performs both exocrine and endocrine functions. The exocrine pancreas consists of two parts, the acinar and duct cells. The primary functions of pancreatic acinar cells are to synthesiz...
  • Pancreatic secretion, conserved biosystem (from KEGG)
    Pancreatic secretion, conserved biosystemThe pancreas performs both exocrine and endocrine functions. The exocrine pancreas consists of two parts, the acinar and duct cells. The primary functions of pancreatic acinar cells are to synthesiz...
  • Regulation of Actin Cytoskeleton, organism-specific biosystem (from WikiPathways)
    Regulation of Actin Cytoskeleton, organism-specific biosystemhttp://www.genome.jp/kegg/pathway/hsa/hsa04810.html
  • Regulation of actin cytoskeleton, organism-specific biosystem (from KEGG)
    Regulation of actin cytoskeleton, organism-specific biosystem
    Regulation of actin cytoskeleton
  • Regulation of actin cytoskeleton, conserved biosystem (from KEGG)
    Regulation of actin cytoskeleton, conserved biosystem
    Regulation of actin cytoskeleton
  • Regulation of insulin secretion, organism-specific biosystem (from REACTOME)
    Regulation of insulin secretion, organism-specific biosystemPancreatic beta cells integrate signals from several metabolites and hormones to control the secretion of insulin. In general, glucose triggers insulin secretion while other factors can amplify or in...
  • Salivary secretion, organism-specific biosystem (from KEGG)
    Salivary secretion, organism-specific biosystemSaliva has manifold functions in maintaining the integrity of the oral tissues, in protecting teeth from caries, in the tasting and ingestion of food, in speech and in the tolerance of tenures, for e...
  • Salivary secretion, conserved biosystem (from KEGG)
    Salivary secretion, conserved biosystemSaliva has manifold functions in maintaining the integrity of the oral tissues, in protecting teeth from caries, in the tasting and ingestion of food, in speech and in the tolerance of tenures, for e...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by GPCR, organism-specific biosystem (from REACTOME)
    Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
  • Taste transduction, organism-specific biosystem (from KEGG)
    Taste transduction, organism-specific biosystemFive basic tastes are recognized by humans and most other animals - bitter, sweet, sour, salty and umami. In vertebrates, taste stimuli are detected by taste receptor cells (TRCs). At least three dis...
  • Taste transduction, conserved biosystem (from KEGG)
    Taste transduction, conserved biosystemFive basic tastes are recognized by humans and most other animals - bitter, sweet, sour, salty and umami. In vertebrates, taste stimuli are detected by taste receptor cells (TRCs). At least three dis...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled acetylcholine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G protein-coupled acetylcholine receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G protein-coupled serotonin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acetylcholine binding ISS
Inferred from Sequence or Structural Similarity
more info
 
neurotransmitter receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidylinositol phospholipase C activity TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
signaling receptor activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled acetylcholine receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell proliferation TAS
Traceable Author Statement
more info
PubMed 
cellular protein modification process TAS
Traceable Author Statement
more info
PubMed 
chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nervous system development TAS
Traceable Author Statement
more info
PubMed 
positive regulation of smooth muscle contraction IEA
Inferred from Electronic Annotation
more info
 
regulation of vascular smooth muscle contraction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
saliva secretion IEA
Inferred from Electronic Annotation
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
smooth muscle contraction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
axon terminus IEA
Inferred from Electronic Annotation
more info
 
basolateral plasma membrane IEA
Inferred from Electronic Annotation
more info
 
cell junction IEA
Inferred from Electronic Annotation
more info
 
dendrite IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dendrite IEA
Inferred from Electronic Annotation
more info
 
glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
integral component of postsynaptic density membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of presynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
muscarinic acetylcholine receptor M3
Names
acetylcholine receptor, muscarinic 3
m3 muscarinic receptor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032046.2 RefSeqGene

    Range
    247144..533521
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000740.3NP_000731.1  muscarinic acetylcholine receptor M3

    See identical proteins and their annotated locations for NP_000731.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and represents use of an alternate promoter, compared to variant 1. Both variants 1 and 2 encode the same protein. The 5' end of this transcript contains L1 element sequence, initiates from an L1 element promoter and expression was predominantly found in placenta. (PMID: 19669628)
    Source sequence(s)
    AF279779, AL356361, AL357499, BQ772140
    Consensus CDS
    CCDS1616.1
    UniProtKB/Swiss-Prot
    P20309
    UniProtKB/TrEMBL
    A0A024R3S2
    Related
    ENSP00000255380.4, OTTHUMP00000037632, ENST00000255380.8, OTTHUMT00000095644
    Conserved Domains (3) summary
    cd14964
    Location:487512
    7tm_GPCRs; TM helix 6 [structural motif]
    cd15299
    Location:66270
    7tmA_mAChR_M3; muscarinic receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors
    cl28897
    Location:484564
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  2. NM_001347716.1NP_001334645.1  muscarinic acetylcholine receptor M3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer variant. Both variants 1 and 2 encode the same protein. The 5' end of this transcript contains long terminal repeat (LTR) sequence, initiates from an LTR promoter and expression was predominantly found in testis. (PMID: 19669628)
    Source sequence(s)
    AC099564, AC104460, AL356361, AL357499, AL513543, BQ772140
    Consensus CDS
    CCDS1616.1
    UniProtKB/Swiss-Prot
    P20309
    UniProtKB/TrEMBL
    A0A024R3S2
    Conserved Domains (3) summary
    cd14964
    Location:487512
    7tm_GPCRs; TM helix 6 [structural motif]
    cd15299
    Location:66270
    7tmA_mAChR_M3; muscarinic receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors
    cl28897
    Location:484564
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    239386565..239915450
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017000153.1XP_016855642.1  muscarinic acetylcholine receptor M3 isoform X1

    UniProtKB/Swiss-Prot
    P20309
    UniProtKB/TrEMBL
    A0A024R3S2
    Conserved Domains (3) summary
    cd14964
    Location:487512
    7tm_GPCRs; TM helix 6 [structural motif]
    cd15299
    Location:66270
    7tmA_mAChR_M3; muscarinic receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors
    cl28897
    Location:484564
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  2. XM_011544043.2XP_011542345.1  muscarinic acetylcholine receptor M3 isoform X1

    See identical proteins and their annotated locations for XP_011542345.1

    UniProtKB/Swiss-Prot
    P20309
    UniProtKB/TrEMBL
    A0A024R3S2
    Conserved Domains (3) summary
    cd14964
    Location:487512
    7tm_GPCRs; TM helix 6 [structural motif]
    cd15299
    Location:66270
    7tmA_mAChR_M3; muscarinic receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors
    cl28897
    Location:484564
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  3. XM_011544044.2XP_011542346.1  muscarinic acetylcholine receptor M3 isoform X1

    See identical proteins and their annotated locations for XP_011542346.1

    UniProtKB/Swiss-Prot
    P20309
    UniProtKB/TrEMBL
    A0A024R3S2
    Conserved Domains (3) summary
    cd14964
    Location:487512
    7tm_GPCRs; TM helix 6 [structural motif]
    cd15299
    Location:66270
    7tmA_mAChR_M3; muscarinic receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors
    cl28897
    Location:484564
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  4. XM_011544041.2XP_011542343.1  muscarinic acetylcholine receptor M3 isoform X1

    See identical proteins and their annotated locations for XP_011542343.1

    UniProtKB/Swiss-Prot
    P20309
    UniProtKB/TrEMBL
    A0A024R3S2
    Conserved Domains (3) summary
    cd14964
    Location:487512
    7tm_GPCRs; TM helix 6 [structural motif]
    cd15299
    Location:66270
    7tmA_mAChR_M3; muscarinic receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors
    cl28897
    Location:484564
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  5. XM_011544047.2XP_011542349.1  muscarinic acetylcholine receptor M3 isoform X1

    See identical proteins and their annotated locations for XP_011542349.1

    UniProtKB/Swiss-Prot
    P20309
    UniProtKB/TrEMBL
    A0A024R3S2
    Conserved Domains (3) summary
    cd14964
    Location:487512
    7tm_GPCRs; TM helix 6 [structural motif]
    cd15299
    Location:66270
    7tmA_mAChR_M3; muscarinic receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors
    cl28897
    Location:484564
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  6. XM_017000155.1XP_016855644.1  muscarinic acetylcholine receptor M3 isoform X1

    UniProtKB/Swiss-Prot
    P20309
    UniProtKB/TrEMBL
    A0A024R3S2
    Conserved Domains (3) summary
    cd14964
    Location:487512
    7tm_GPCRs; TM helix 6 [structural motif]
    cd15299
    Location:66270
    7tmA_mAChR_M3; muscarinic receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors
    cl28897
    Location:484564
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  7. XM_011544046.2XP_011542348.1  muscarinic acetylcholine receptor M3 isoform X1

    See identical proteins and their annotated locations for XP_011542348.1

    UniProtKB/Swiss-Prot
    P20309
    UniProtKB/TrEMBL
    A0A024R3S2
    Conserved Domains (3) summary
    cd14964
    Location:487512
    7tm_GPCRs; TM helix 6 [structural motif]
    cd15299
    Location:66270
    7tmA_mAChR_M3; muscarinic receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors
    cl28897
    Location:484564
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  8. XM_017000159.1XP_016855648.1  muscarinic acetylcholine receptor M3 isoform X1

    UniProtKB/Swiss-Prot
    P20309
    UniProtKB/TrEMBL
    A0A024R3S2
    Conserved Domains (3) summary
    cd14964
    Location:487512
    7tm_GPCRs; TM helix 6 [structural motif]
    cd15299
    Location:66270
    7tmA_mAChR_M3; muscarinic receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors
    cl28897
    Location:484564
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  9. XM_017000156.1XP_016855645.1  muscarinic acetylcholine receptor M3 isoform X1

    UniProtKB/Swiss-Prot
    P20309
    UniProtKB/TrEMBL
    A0A024R3S2
    Conserved Domains (3) summary
    cd14964
    Location:487512
    7tm_GPCRs; TM helix 6 [structural motif]
    cd15299
    Location:66270
    7tmA_mAChR_M3; muscarinic receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors
    cl28897
    Location:484564
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  10. XM_005273032.3XP_005273089.1  muscarinic acetylcholine receptor M3 isoform X1

    See identical proteins and their annotated locations for XP_005273089.1

    UniProtKB/Swiss-Prot
    P20309
    UniProtKB/TrEMBL
    A0A024R3S2
    Conserved Domains (3) summary
    cd14964
    Location:487512
    7tm_GPCRs; TM helix 6 [structural motif]
    cd15299
    Location:66270
    7tmA_mAChR_M3; muscarinic receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors
    cl28897
    Location:484564
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  11. XM_017000162.1XP_016855651.1  muscarinic acetylcholine receptor M3 isoform X1

    UniProtKB/Swiss-Prot
    P20309
    UniProtKB/TrEMBL
    A0A024R3S2
    Conserved Domains (3) summary
    cd14964
    Location:487512
    7tm_GPCRs; TM helix 6 [structural motif]
    cd15299
    Location:66270
    7tmA_mAChR_M3; muscarinic receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors
    cl28897
    Location:484564
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  12. XM_017000161.1XP_016855650.1  muscarinic acetylcholine receptor M3 isoform X1

    UniProtKB/Swiss-Prot
    P20309
    UniProtKB/TrEMBL
    A0A024R3S2
    Conserved Domains (3) summary
    cd14964
    Location:487512
    7tm_GPCRs; TM helix 6 [structural motif]
    cd15299
    Location:66270
    7tmA_mAChR_M3; muscarinic receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors
    cl28897
    Location:484564
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  13. XM_017000158.1XP_016855647.1  muscarinic acetylcholine receptor M3 isoform X1

    UniProtKB/Swiss-Prot
    P20309
    UniProtKB/TrEMBL
    A0A024R3S2
    Conserved Domains (3) summary
    cd14964
    Location:487512
    7tm_GPCRs; TM helix 6 [structural motif]
    cd15299
    Location:66270
    7tmA_mAChR_M3; muscarinic receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors
    cl28897
    Location:484564
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  14. XM_017000152.2XP_016855641.1  muscarinic acetylcholine receptor M3 isoform X1

    UniProtKB/Swiss-Prot
    P20309
    UniProtKB/TrEMBL
    A0A024R3S2
    Conserved Domains (3) summary
    cd14964
    Location:487512
    7tm_GPCRs; TM helix 6 [structural motif]
    cd15299
    Location:66270
    7tmA_mAChR_M3; muscarinic receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors
    cl28897
    Location:484564
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  15. XM_017000154.1XP_016855643.1  muscarinic acetylcholine receptor M3 isoform X1

    UniProtKB/Swiss-Prot
    P20309
    UniProtKB/TrEMBL
    A0A024R3S2
    Conserved Domains (3) summary
    cd14964
    Location:487512
    7tm_GPCRs; TM helix 6 [structural motif]
    cd15299
    Location:66270
    7tmA_mAChR_M3; muscarinic receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors
    cl28897
    Location:484564
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  16. XM_017000157.2XP_016855646.1  muscarinic acetylcholine receptor M3 isoform X1

    UniProtKB/Swiss-Prot
    P20309
    UniProtKB/TrEMBL
    A0A024R3S2
    Conserved Domains (3) summary
    cd14964
    Location:487512
    7tm_GPCRs; TM helix 6 [structural motif]
    cd15299
    Location:66270
    7tmA_mAChR_M3; muscarinic receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors
    cl28897
    Location:484564
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  17. XM_017000160.2XP_016855649.1  muscarinic acetylcholine receptor M3 isoform X1

    UniProtKB/Swiss-Prot
    P20309
    UniProtKB/TrEMBL
    A0A024R3S2
    Conserved Domains (3) summary
    cd14964
    Location:487512
    7tm_GPCRs; TM helix 6 [structural motif]
    cd15299
    Location:66270
    7tmA_mAChR_M3; muscarinic receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors
    cl28897
    Location:484564
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  18. XM_017000163.2XP_016855652.1  muscarinic acetylcholine receptor M3 isoform X1

    UniProtKB/Swiss-Prot
    P20309
    UniProtKB/TrEMBL
    A0A024R3S2
    Conserved Domains (3) summary
    cd14964
    Location:487512
    7tm_GPCRs; TM helix 6 [structural motif]
    cd15299
    Location:66270
    7tmA_mAChR_M3; muscarinic receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors
    cl28897
    Location:484564
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
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