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Chrm3 cholinergic receptor, muscarinic 3, cardiac [ Mus musculus (house mouse) ]

Gene ID: 12671, updated on 12-Aug-2018

Summary

Official Symbol
Chrm3provided by MGI
Official Full Name
cholinergic receptor, muscarinic 3, cardiacprovided by MGI
Primary source
MGI:MGI:88398
See related
Ensembl:ENSMUSG00000046159 Vega:OTTMUSG00000048429
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
M3; M3R; Chrm-3
Expression
Broad expression in cortex adult (RPKM 8.4), bladder adult (RPKM 7.2) and 17 other tissues See more
Orthologs

Genomic context

See Chrm3 in Genome Data Viewer
Location:
13 A1; 13 3.72 cM
Exon count:
5
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 13 NC_000079.6 (9875488..10360914, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (9875859..10360049, complement)

Chromosome 13 - NC_000079.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 36423 Neighboring gene zinc finger, MYND domain containing 11 Neighboring gene predicted gene, 40665 Neighboring gene uncharacterized LOC108168064 Neighboring gene predicted gene, 36525 Neighboring gene predicted gene, 40666

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
G-protein coupled acetylcholine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G-protein coupled acetylcholine receptor activity ISO
Inferred from Sequence Orthology
more info
 
G-protein coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G-protein coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
G-protein coupled serotonin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acetylcholine binding ISO
Inferred from Sequence Orthology
more info
 
drug binding ISO
Inferred from Sequence Orthology
more info
 
neurotransmitter receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G-protein coupled acetylcholine receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
G-protein coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of smooth muscle contraction IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of smooth muscle contraction ISO
Inferred from Sequence Orthology
more info
 
regulation of vascular smooth muscle contraction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of vascular smooth muscle contraction ISO
Inferred from Sequence Orthology
more info
 
regulation of vasoconstriction ISO
Inferred from Sequence Orthology
more info
 
saliva secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
smooth muscle contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
synaptic transmission, cholinergic IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
asymmetric synapse ISO
Inferred from Sequence Orthology
more info
 
axon terminus ISO
Inferred from Sequence Orthology
more info
 
cell junction IEA
Inferred from Electronic Annotation
more info
 
dendrite IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dendrite ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
muscarinic acetylcholine receptor M3
Names
AChR M3
mm3 mAChR
muscarinic acetylcholine receptor 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_033269.4NP_150372.1  muscarinic acetylcholine receptor M3

    See identical proteins and their annotated locations for NP_150372.1

    Status: VALIDATED

    Source sequence(s)
    AK051841, AK080950
    Consensus CDS
    CCDS26238.1
    UniProtKB/Swiss-Prot
    Q9ERZ3
    UniProtKB/TrEMBL
    Q542R4
    Related
    ENSMUSP00000140131.1, OTTMUSP00000067594, ENSMUST00000187510.6, OTTMUST00000124140
    Conserved Domains (2) summary
    pfam00001
    Location:84265
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:76208
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000079.6 Reference GRCm38.p4 C57BL/6J

    Range
    9875488..10360914 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006516468.3XP_006516531.1  muscarinic acetylcholine receptor M3 isoform X1

    See identical proteins and their annotated locations for XP_006516531.1

    UniProtKB/Swiss-Prot
    Q9ERZ3
    UniProtKB/TrEMBL
    Q542R4
    Conserved Domains (2) summary
    pfam00001
    Location:84265
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:76208
    7tm_4; Olfactory receptor
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