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SYNRG synergin gamma [ Homo sapiens (human) ]

Gene ID: 11276, updated on 2-Nov-2024

Summary

Official Symbol
SYNRGprovided by HGNC
Official Full Name
synergin gammaprovided by HGNC
Primary source
HGNC:HGNC:557
See related
Ensembl:ENSG00000275066 MIM:607291; AllianceGenome:HGNC:557
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SYNG; AP1GBP1
Summary
This gene encodes a protein that interacts with the gamma subunit of AP1 clathrin-adaptor complex. The AP1 complex is located at the trans-Golgi network and associates specific proteins with clathrin-coated vesicles. This encoded protein may act to connect the AP1 complex to other proteins. Alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in lymph node (RPKM 8.0), spleen (RPKM 6.7) and 25 other tissues See more
Orthologs
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Genomic context

See SYNRG in Genome Data Viewer
Location:
17q12
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (37514807..37609418, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (38501491..38596398, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (35874910..35969466, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene transcriptional adaptor 2A Neighboring gene ribosomal protein L24 pseudogene Neighboring gene NANOG hESC enhancer GRCh37_chr17:35814497-35815074 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr17:35815591-35816092 Neighboring gene MPRA-validated peak2830 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:35843239-35843740 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:35851097-35851882 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:35867619-35868119 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:35867118-35867618 Neighboring gene dual specificity phosphatase 14 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:35872759-35873272 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr17:35901785-35902984 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:35949209-35949710 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:35949711-35950210 Neighboring gene microRNA 378j Neighboring gene DExD-box helicase 52 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36001021-36001522 Neighboring gene uncharacterized LOC105371756

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genomic association analysis identifies multiple loci influencing antihypertensive response to an angiotensin II receptor blocker.
EBI GWAS Catalog
GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ34482, MGC104959

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in endocytosis IEA
Inferred from Electronic Annotation
more info
 
involved_in intracellular protein transport TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
part_of AP-1 adaptor complex TAS
Traceable Author Statement
more info
PubMed 
located_in Golgi apparatus TAS
Traceable Author Statement
more info
PubMed 
part_of clathrin coat of trans-Golgi network vesicle IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm TAS
Traceable Author Statement
more info
PubMed 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
synergin gamma
Names
AP1 gamma subunit binding protein 1
AP1 subunit gamma-binding protein 1
adaptor-related protein complex 1 gamma subunit-binding protein 1
gamma-synergin

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163544.3NP_001157016.1  synergin gamma isoform 4

    See identical proteins and their annotated locations for NP_001157016.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (4) that is shorter than isoform 1.
    Source sequence(s)
    AC243585, AF169548, BC143478, DB085203, N93929
    Conserved Domains (2) summary
    cd00052
    Location:238289
    EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
    cl00928
    Location:116150
    dsDNA_bind; Double-stranded DNA-binding domain
  2. NM_001163545.3NP_001157017.1  synergin gamma isoform 5

    See identical proteins and their annotated locations for NP_001157017.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses an alternate in-frame splice site in the 5' coding region and lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (5) that is shorter than isoform 1.
    Source sequence(s)
    AC243585, AF169548, BC117313, DB085203, N93929
    Consensus CDS
    CCDS59284.1
    Related
    ENSP00000477885.1, ENST00000619541.4
    Conserved Domains (2) summary
    cd00052
    Location:237288
    EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
    cl00928
    Location:115149
    dsDNA_bind; Double-stranded DNA-binding domain
  3. NM_001163546.3NP_001157018.1  synergin gamma isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks an alternate in-frame exon and uses an alternate in-frame splice site in the central coding region, and lacks an alternate in-frame exon in the 3' coding region, compared to variant 1, resulting in an isoform (6) that is shorter than isoform 1.
    Source sequence(s)
    AC243585, AF169548, BC084536, BC090930, DB085203, N93929
    Consensus CDS
    CCDS59285.1
    Related
    ENSP00000482962.1, ENST00000616179.4
    Conserved Domains (2) summary
    cd00052
    Location:238289
    EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
    cl00928
    Location:116150
    dsDNA_bind; Double-stranded DNA-binding domain
  4. NM_001163547.3NP_001157019.1  synergin gamma isoform 7

    See identical proteins and their annotated locations for NP_001157019.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) lacks two alternate in-frame exons and uses an alternate in-frame splice site in the central coding region, compared to variant 1, resulting in an isoform (7) that is shorter than isoform 1.
    Source sequence(s)
    AC243585, AF169548, BC143476, DB085203, N93929
    Consensus CDS
    CCDS54113.1
    Related
    ENSP00000481151.1, ENST00000614941.4
    Conserved Domains (2) summary
    cd00052
    Location:238288
    EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
    cl00928
    Location:116150
    dsDNA_bind; Double-stranded DNA-binding domain
  5. NM_001405103.1NP_001392032.1  synergin gamma isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC243585
  6. NM_007247.6NP_009178.3  synergin gamma isoform 1

    See identical proteins and their annotated locations for NP_009178.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC243585, AF169548, BC090930, DB085203, N93929
    Consensus CDS
    CCDS11321.1
    UniProtKB/Swiss-Prot
    A8MWU4, B7ZKZ2, B7ZKZ3, Q17RI2, Q5BKU5, Q6ZT17, Q9UMZ2
    Related
    ENSP00000483453.1, ENST00000612223.5
    Conserved Domains (2) summary
    cd00052
    Location:316367
    EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
    cl00928
    Location:116150
    dsDNA_bind; Double-stranded DNA-binding domain
  7. NM_080550.5NP_542117.3  synergin gamma isoform 2

    See identical proteins and their annotated locations for NP_542117.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in both the central and 3' coding regions, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
    Source sequence(s)
    AC243585, AF169548, BC090930, DB085203, N93929
    Consensus CDS
    CCDS11322.2
    Related
    ENSP00000484529.1, ENST00000621136.4
    Conserved Domains (2) summary
    cd00052
    Location:238289
    EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
    cl00928
    Location:116150
    dsDNA_bind; Double-stranded DNA-binding domain
  8. NM_198882.3NP_942583.1  synergin gamma isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the central coding region but includes an additional in-frame exon in the 3' coding region, compared to variant 1, resulting in an isoform (3) that is shorter than isoform 1.
    Source sequence(s)
    AC243585, BC090930, BC143452, DB085203, N93929
    Consensus CDS
    CCDS54114.1
    Related
    ENSP00000483063.1, ENST00000622045.4
    Conserved Domains (2) summary
    cd00052
    Location:238289
    EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
    cl00928
    Location:116150
    dsDNA_bind; Double-stranded DNA-binding domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    37514807..37609418 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017024081.3XP_016879570.1  synergin gamma isoform X44

  2. XM_047435226.1XP_047291182.1  synergin gamma isoform X4

  3. XM_047435249.1XP_047291205.1  synergin gamma isoform X43

  4. XM_047435247.1XP_047291203.1  synergin gamma isoform X41

  5. XM_047435246.1XP_047291202.1  synergin gamma isoform X40

  6. XM_017024102.1XP_016879591.1  synergin gamma isoform X37

  7. XM_017024101.2XP_016879590.1  synergin gamma isoform X36

    Conserved Domains (3) summary
    cd00052
    Location:315366
    EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
    pfam09606
    Location:32130
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cl00928
    Location:115149
    dsDNA_bind; Double-stranded DNA-binding domain
  8. XM_047435243.1XP_047291199.1  synergin gamma isoform X32

  9. XM_047435245.1XP_047291201.1  synergin gamma isoform X35

  10. XM_047435242.1XP_047291198.1  synergin gamma isoform X31

  11. XM_017024094.2XP_016879583.1  synergin gamma isoform X26

  12. XM_047435240.1XP_047291196.1  synergin gamma isoform X24

  13. XM_047435238.1XP_047291194.1  synergin gamma isoform X22

  14. XM_047435235.1XP_047291191.1  synergin gamma isoform X18

  15. XM_047435231.1XP_047291187.1  synergin gamma isoform X12

  16. XM_047435237.1XP_047291193.1  synergin gamma isoform X21

  17. XM_047435234.1XP_047291190.1  synergin gamma isoform X17

  18. XM_047435230.1XP_047291186.1  synergin gamma isoform X11

  19. XM_047435232.1XP_047291188.1  synergin gamma isoform X13

  20. XM_047435229.1XP_047291185.1  synergin gamma isoform X8

  21. XM_047435227.1XP_047291183.1  synergin gamma isoform X6

  22. XM_047435225.1XP_047291181.1  synergin gamma isoform X3

  23. XM_017024077.1XP_016879566.1  synergin gamma isoform X1

  24. XM_047435248.1XP_047291204.1  synergin gamma isoform X42

  25. XM_017024104.3XP_016879593.1  synergin gamma isoform X39

  26. XM_017024106.2XP_016879595.1  synergin gamma isoform X38

  27. XM_017024100.2XP_016879589.1  synergin gamma isoform X34

  28. XM_017024098.3XP_016879587.1  synergin gamma isoform X30

  29. XM_047435244.1XP_047291200.1  synergin gamma isoform X33

  30. XM_017024097.2XP_016879586.1  synergin gamma isoform X29

  31. XM_017024095.2XP_016879584.1  synergin gamma isoform X27

  32. XM_017024093.3XP_016879582.1  synergin gamma isoform X25

  33. XM_047435241.1XP_047291197.1  synergin gamma isoform X28

  34. XM_047435239.1XP_047291195.1  synergin gamma isoform X23

  35. XM_047435233.1XP_047291189.1  synergin gamma isoform X14

  36. XM_047435236.1XP_047291192.1  synergin gamma isoform X20

  37. XM_017024087.2XP_016879576.1  synergin gamma isoform X16

  38. XM_017024084.2XP_016879573.1  synergin gamma isoform X10

  39. XM_017024089.2XP_016879578.1  synergin gamma isoform X19

  40. XM_017024086.2XP_016879575.1  synergin gamma isoform X15

  41. XM_017024083.2XP_016879572.1  synergin gamma isoform X9

  42. XM_047435228.1XP_047291184.1  synergin gamma isoform X7

  43. XM_017024082.2XP_016879571.1  synergin gamma isoform X5

  44. XM_005256980.6XP_005257037.1  synergin gamma isoform X2

    See identical proteins and their annotated locations for XP_005257037.1

    Conserved Domains (2) summary
    cd00052
    Location:417468
    EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
    cl00928
    Location:116150
    dsDNA_bind; Double-stranded DNA-binding domain

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187614.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    1753975..1848537 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054329235.1XP_054185210.1  synergin gamma isoform X4

  2. XM_054329275.1XP_054185250.1  synergin gamma isoform X43

  3. XM_054329273.1XP_054185248.1  synergin gamma isoform X41

  4. XM_054329272.1XP_054185247.1  synergin gamma isoform X40

  5. XM_054329269.1XP_054185244.1  synergin gamma isoform X37

  6. XM_054329267.1XP_054185242.1  synergin gamma isoform X36

  7. XM_054329263.1XP_054185238.1  synergin gamma isoform X32

  8. XM_054329266.1XP_054185241.1  synergin gamma isoform X35

  9. XM_054329262.1XP_054185237.1  synergin gamma isoform X31

  10. XM_054329257.1XP_054185232.1  synergin gamma isoform X26

  11. XM_054329255.1XP_054185230.1  synergin gamma isoform X24

  12. XM_054329253.1XP_054185228.1  synergin gamma isoform X22

  13. XM_054329249.1XP_054185224.1  synergin gamma isoform X18

  14. XM_054329243.1XP_054185218.1  synergin gamma isoform X12

  15. XM_054329252.1XP_054185227.1  synergin gamma isoform X21

  16. XM_054329248.1XP_054185223.1  synergin gamma isoform X17

  17. XM_054329242.1XP_054185217.1  synergin gamma isoform X11

  18. XM_054329244.1XP_054185219.1  synergin gamma isoform X13

  19. XM_054329239.1XP_054185214.1  synergin gamma isoform X8

  20. XM_054329237.1XP_054185212.1  synergin gamma isoform X6

  21. XM_054329234.1XP_054185209.1  synergin gamma isoform X3

  22. XM_054329232.1XP_054185207.1  synergin gamma isoform X1

  23. XM_054329274.1XP_054185249.1  synergin gamma isoform X42

  24. XM_054329271.1XP_054185246.1  synergin gamma isoform X39

  25. XM_054329270.1XP_054185245.1  synergin gamma isoform X38

  26. XM_054329268.1XP_054185243.1  synergin gamma isoform X45

  27. XM_054329265.1XP_054185240.1  synergin gamma isoform X34

  28. XM_054329261.1XP_054185236.1  synergin gamma isoform X30

  29. XM_054329264.1XP_054185239.1  synergin gamma isoform X33

  30. XM_054329260.1XP_054185235.1  synergin gamma isoform X29

  31. XM_054329258.1XP_054185233.1  synergin gamma isoform X27

  32. XM_054329256.1XP_054185231.1  synergin gamma isoform X25

  33. XM_054329259.1XP_054185234.1  synergin gamma isoform X28

  34. XM_054329254.1XP_054185229.1  synergin gamma isoform X23

  35. XM_054329245.1XP_054185220.1  synergin gamma isoform X14

  36. XM_054329251.1XP_054185226.1  synergin gamma isoform X20

  37. XM_054329247.1XP_054185222.1  synergin gamma isoform X16

  38. XM_054329241.1XP_054185216.1  synergin gamma isoform X10

  39. XM_054329250.1XP_054185225.1  synergin gamma isoform X19

  40. XM_054329246.1XP_054185221.1  synergin gamma isoform X15

  41. XM_054329240.1XP_054185215.1  synergin gamma isoform X9

  42. XM_054329238.1XP_054185213.1  synergin gamma isoform X7

  43. XM_054329236.1XP_054185211.1  synergin gamma isoform X5

  44. XM_054329233.1XP_054185208.1  synergin gamma isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    38501491..38596398 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054314866.1XP_054170841.1  synergin gamma isoform X4

  2. XM_054314906.1XP_054170881.1  synergin gamma isoform X43

  3. XM_054314904.1XP_054170879.1  synergin gamma isoform X41

  4. XM_054314903.1XP_054170878.1  synergin gamma isoform X40

  5. XM_054314900.1XP_054170875.1  synergin gamma isoform X37

  6. XM_054314898.1XP_054170873.1  synergin gamma isoform X36

  7. XM_054314894.1XP_054170869.1  synergin gamma isoform X32

  8. XM_054314897.1XP_054170872.1  synergin gamma isoform X35

  9. XM_054314893.1XP_054170868.1  synergin gamma isoform X31

  10. XM_054314888.1XP_054170863.1  synergin gamma isoform X26

  11. XM_054314886.1XP_054170861.1  synergin gamma isoform X24

  12. XM_054314884.1XP_054170859.1  synergin gamma isoform X22

  13. XM_054314880.1XP_054170855.1  synergin gamma isoform X18

  14. XM_054314874.1XP_054170849.1  synergin gamma isoform X12

  15. XM_054314883.1XP_054170858.1  synergin gamma isoform X21

  16. XM_054314879.1XP_054170854.1  synergin gamma isoform X17

  17. XM_054314873.1XP_054170848.1  synergin gamma isoform X11

  18. XM_054314875.1XP_054170850.1  synergin gamma isoform X13

  19. XM_054314870.1XP_054170845.1  synergin gamma isoform X8

  20. XM_054314868.1XP_054170843.1  synergin gamma isoform X6

  21. XM_054314865.1XP_054170840.1  synergin gamma isoform X3

  22. XM_054314863.1XP_054170838.1  synergin gamma isoform X1

  23. XM_054314905.1XP_054170880.1  synergin gamma isoform X42

  24. XM_054314902.1XP_054170877.1  synergin gamma isoform X39

  25. XM_054314901.1XP_054170876.1  synergin gamma isoform X38

  26. XM_054314899.1XP_054170874.1  synergin gamma isoform X46

  27. XM_054314896.1XP_054170871.1  synergin gamma isoform X34

  28. XM_054314892.1XP_054170867.1  synergin gamma isoform X30

  29. XM_054314895.1XP_054170870.1  synergin gamma isoform X33

  30. XM_054314891.1XP_054170866.1  synergin gamma isoform X29

  31. XM_054314889.1XP_054170864.1  synergin gamma isoform X27

  32. XM_054314887.1XP_054170862.1  synergin gamma isoform X25

  33. XM_054314890.1XP_054170865.1  synergin gamma isoform X28

  34. XM_054314885.1XP_054170860.1  synergin gamma isoform X23

  35. XM_054314876.1XP_054170851.1  synergin gamma isoform X14

  36. XM_054314882.1XP_054170857.1  synergin gamma isoform X20

  37. XM_054314878.1XP_054170853.1  synergin gamma isoform X16

  38. XM_054314872.1XP_054170847.1  synergin gamma isoform X10

  39. XM_054314881.1XP_054170856.1  synergin gamma isoform X19

  40. XM_054314877.1XP_054170852.1  synergin gamma isoform X15

  41. XM_054314871.1XP_054170846.1  synergin gamma isoform X9

  42. XM_054314869.1XP_054170844.1  synergin gamma isoform X7

  43. XM_054314867.1XP_054170842.1  synergin gamma isoform X5

  44. XM_054314864.1XP_054170839.1  synergin gamma isoform X2